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Pharmacogenomics and tailored polypharmacy: an 80-year-old lady with rosuvastatin-associated rhabdomyolysis and maprotiline-related Ogilvie's syndrome
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Author: BarisicBlazenka, Popovic-GrleSanja, SreterKatherina B

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a patient who developed acute colonic pseudo-obstruction (Ogilvie's syndrome) after taking maprotiline, a tetracyclic antidepressant. This rare side effect highlights the importance of being aware of potential drug interactions, especially in elderly patients who take multiple medications.
Paper Details　
Original Abstract of the Article :
What is known and objectives: Multiple adverse drug reactions (ADRs) are expected, and thus should be prevented in the elderly comorbid patient on polypharmacy. Rosuvastatin is commonly prescribed for the treatment and prevention of atherosclerotic diseases, and in rare cases, is associated with rha...See full text at original site
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引用元：
https://doi.org/10.5414/CP202784

データ提供：米国国立医学図書館（NLM）

Polypharmacy in the Elderly: A Tightrope Walk

This case report explores the challenges of polypharmacy in the elderly, highlighting the potential for drug interactions and adverse drug reactions (ADRs) in patients taking multiple medications. The researchers describe the case of an 80-year-old woman who experienced both rosuvastatin-associated rhabdomyolysis and maprotiline-related Ogilvie's syndrome, underscoring the importance of careful medication selection and monitoring in this vulnerable population.

Navigating the Complexities of Polypharmacy: A Need for Vigilance

The case report highlights the potential for serious adverse effects when multiple medications are used, particularly in the elderly. The researchers emphasize the need for careful medication selection and monitoring, considering individual patient characteristics and potential drug interactions. Furthermore, the study highlights the importance of pharmacogenomics, the study of how genetic variations influence drug responses, in optimizing medication choices and minimizing ADRs.

A Tailored Approach to Polypharmacy: A Path to Safer Treatment

This case report underscores the importance of a personalized approach to polypharmacy in the elderly, considering individual patient factors and potential drug interactions. The study's emphasis on pharmacogenomics and tailored polypharmacy aligns with the evolving paradigm of precision medicine, aiming to optimize medication choices and minimize the risk of ADRs in this vulnerable population.

Dr. Camel's Conclusion

Polypharmacy in the elderly can be a tightrope walk, balancing the potential benefits of multiple medications with the risk of adverse drug reactions. This case report serves as a reminder of the importance of careful medication selection, monitoring, and a tailored approach to managing polypharmacy in this vulnerable population. By navigating the complexities of polypharmacy, healthcare providers can help ensure the safe and effective use of medications in older adults, minimizing the risk of adverse effects and maximizing their quality of life.

Date :
  1. Date Completed 2017-11-03
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28257284

DOI: Digital Object Identifier

10.5414/CP202784

SNS
PICO Info
in preparation
Languages

English

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