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Optimal dosage and duration of pivmecillinam treatment for uncomplicated lower urinary tract infections: a systematic review and meta-analysis.

Author: JensenKatrin, KranzJennifer, KunathFrank, NaberKurt, PinartMariona, ProctorTanja, SchmidtStefanie, WagenlehnerFlorian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis of 24 randomized controlled trials found insufficient evidence to support the use of an optimal combination of dosage, frequency, and duration of pivmecillinam therapy for uncomplicated lower urinary tract infections (UTIs). No significant difference in clinical cure was found between different dosage regimens. Although higher dosages tended to improve bacteriological cure, the results were not statistically significant. Patients treated with high dosages were more likely to report mild to moderate adverse events.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the efficacy and safety of different pivmecillinam (PIV) regimes for uncomplicated lower urinary tract infections (UTIs). METHODS: The MEDLINE, Embase, and Cochrane Library databases were searched. Randomized controlled clinical trials (RCTs) involving adults or children with ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijid.2017.03.012

データ提供：米国国立医学図書館（NLM）

Pivmecillinam for Uncomplicated Lower Urinary Tract Infections: Navigating the Desert of Dosage and Duration

This study reviews the evidence on pivmecillinam (PIV) treatment for uncomplicated lower urinary tract infections (UTIs) in adults and children. The authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing different PIV regimens and PIV versus other antibiotics. Their findings indicate that there is insufficient evidence to support a specific optimal dosage, frequency, or duration of PIV therapy for uncomplicated UTIs. This conclusion is based on the high risk of bias, poor reporting, and heterogeneous data across the included studies. The authors emphasize the need for future research with rigorous methodology to establish optimal PIV treatment regimens for uncomplicated UTIs.

Unraveling the Desert of Pivmecillinam Treatment: A Quest for Optimal Dosage and Duration

Imagine UTI, a common infection, as a desert oasis in the landscape of our urinary system. This research delves into the effectiveness of pivmecillinam (PIV) treatment for these infections, focusing on the optimal dosage and duration of therapy. The authors reviewed a wide range of studies and conducted a comprehensive meta-analysis. Their findings highlight the need for further research to clarify the best approach to PIV treatment, ensuring optimal outcomes for patients with uncomplicated UTIs.

A Desert Oasis of Optimal Treatment: Finding the Right Dosage and Duration

This research underscores the importance of evidence-based medicine in guiding treatment decisions. The authors’ review of pivmecillinam (PIV) treatment for uncomplicated UTIs highlights the need for further research to establish optimal dosing and duration of therapy. Their findings encourage a more rigorous and systematic approach to evaluating treatment options for UTIs, ensuring the most effective and safe care for patients.

Dr. Camel's Conclusion

This research emphasizes the importance of carefully navigating the desert of treatment options for UTIs. A deeper understanding of the optimal dosage and duration of pivmecillinam (PIV) therapy is crucial for ensuring effective and safe treatment for patients.

Date :
  1. Date Completed 2017-10-12
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

28341436

DOI: Digital Object Identifier

10.1016/j.ijid.2017.03.012

Related Literature

Article Analysis
・Effective treatment of urinary tract infections
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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