Effective treatment of urinary tract infections: A Synthesis of Findings from 44 Studies

  1. Home
  2. Effective treatment of urinary tract infections
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of urinary tract infections: A Synthesis of Findings from 44 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of urinary tract infections: A Synthesis of Findings from 44 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Uncomplicated urinary tract infections (UTIs) are typically treated with antibiotics, but there is increasing concern about the emergence of antibiotic resistance. Therefore, new treatment approaches are being explored to reduce the use of antibiotics. Some research suggests that initial treatment with ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), may be effective in reducing antibiotic use, reserving antibiotics for patients who experience persistent or recurrent symptoms. 22

Other studies have shown that antibiotics like trimethoprim and nitrofurantoin are effective for treating UTIs in young women. 11

Additionally, there is evidence suggesting that cranberry extract might be helpful in improving UTI symptoms. 34

Treatment Summary

In addition to antibiotics, treatment for UTIs may include NSAIDs like ibuprofen, antibiotics like trimethoprim and nitrofurantoin, and non-antibiotic therapies like cranberry extract. 22 11 34

Benefits and Risks

Benefit Summary

For UTI treatment, there is potential for NSAIDs and non-antibiotic therapies like cranberry extract to be effective. 22 34

Risk Summary

Using antibiotics carries the risks of increasing antibiotic resistance and experiencing side effects. 22

Comparison Between Studies

Commonalities in Studies

Many studies show that antibiotics are effective in treating UTIs. 11 35

Differences in Studies

There are variations among studies in terms of effective antibiotic types, treatment durations, and overall treatment approaches. 11 35

Consistency and Inconsistencies in Results

Research on UTI treatment methods demonstrates some consistency while also revealing inconsistencies. For instance, while NSAIDs and cranberry extract show potential as alternative approaches to reduce antibiotic use, more research is needed to definitively determine their effectiveness compared to antibiotics. 22 34

Important Considerations for Real-World Application

UTI treatment methods vary depending on factors like the patient's age, symptoms, and the type of bacteria causing the infection. It is crucial to consult with a doctor rather than self-treating. Additionally, antibiotic overuse contributes to the rise of antibiotic-resistant bacteria, so it's important to adhere to a doctor's instructions for taking antibiotics. 22 35

Limitations of Current Research

There are still many unanswered questions regarding UTI treatment methods. For example, further research is needed to fully understand the effectiveness of NSAIDs and cranberry extract, as well as their ability to control the increase in antibiotic-resistant bacteria. 22 34

Future Research Directions

Research on UTI treatment should prioritize the development of new treatment methods that can curb the rise of antibiotic-resistant bacteria. It's also essential to conduct more studies on the efficacy and safety of NSAIDs and cranberry extract, as well as to develop personalized treatment plans that consider individual patient factors like age, symptoms, and the specific bacteria causing the infection. 22 34 35

Conclusion

While antibiotics are the usual treatment for UTIs, there is growing evidence that NSAIDs and non-antibiotic therapies like cranberry extract might be effective alternatives. However, more research is needed to confirm their effectiveness compared to antibiotics. It is always recommended to consult a doctor for UTI treatment instead of self-treating. 22 34

List of Treatment Keywords

Antibiotics, NSAIDs, Cranberry extract 22 34

Keywords
Benefit Keywords
Sterilize urine
Treat urinary tract infection
1
Improved urine sterility
2
UTI treatment
3
UTI treatment
4
UTI treatment
5
Reduced colonization
Reduced infection incidence
6
Eradicated urinary tract infections
7
High cure rates
Minimal side effects
8
Easy to administer
Effective UTI treatment
Few adverse reactions
Safe treatment
9
Eradicated urinary tract infections
10
Effective treatment
Well tolerated
11
Improved understanding of urinary tract infection treatment
12
Effective treatment of UTIs
13
UTI treatment effective
14
UTI cure
16
UTI prevention
17
UTI treatment
18
Urinary tract infection treatment
19
UTI treatment
20
Shorter treatment
21
Reduced antibiotic use
22
UTI reduction
Urinary symptom improvement
23
CHM for UTI
24
Alleviate UTI symptoms
Reduce recurrence rate
26
Effective UTI treatment
27
UTI treatment
28
Improved UTI treatment
29
Improved fUTI treatment
31
Reduced UTI risk
32
Non-antibiotic options
UTI prevention and treatment
33
UTI treatment
34
Improved uUTI treatment
35
Bacteriophage therapy for UTI
36
Reduced UTI recurrence
37
UTI reduction
38
Shorter IV antibiotic courses
39
Reduced cystitis recurrence
40
UTI resolution with stone removal
41
Safe
UTI treatment
42
Cystitis treatment
Microcirculation improvement
43
Reduced cystitis recurrence
44
Risk Keywords
Recurrence of symptoms
2
Side effects
6
Recurrence of infections
7
Nausea
Vomiting
Vulvovaginal irritation
9
Concerns about occult pyelonephritis and renal scarring
13
Problematic to define optimal regimen for pregnancy
15
Persistent symptoms
16
High dropout rate
Side effects
17
Antimicrobial resistance
21
Microbial resistance
Side effects
24
Antibiotic resistance
25
Adverse events
27
Delayed treatment
Renal scarring
30
Drug resistance
38
Recurrent UTI
Stone formation
41
Literature analysis of 44 papers
Positive Content
41
Neutral Content
1
Negative Content
2
Article Type
27
6
16
11
44
1.

Comparison of ampicillin and trimethoprim-sulfamethoxazole in the short-term treatment of urinary tract infection.

Author: LaplanteL, BeaudryC

Sterilize urine
Treat urinary tract infection

Ampicillin was more effective than trimethoprim-sulfamethoxazole in treating urinary tract infections in 40 patients, leading to a greater sterilization of urine. However, trimethoprim-sulfamethoxazole was comparable to ampicillin in managing more complex infections over a 3-month period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Comparative studies of the effectiveness of 1-day treatment and 7-day treatment with sulfamerazine/trimethoprim (Berlocombin) of patients with urinary tract infection].

Author: FünfstückR, JansaU, SteinG, SchneiderS

Improved urine sterility
Recurrence of symptoms

A study of 21 women with chronic pyelonephritis and acute lower urinary tract infection found that a 7-day treatment with sulfamerazine/trimethoprime was more effective than a 1-day treatment in sterilizing urine and reducing bacterial adherence to uroepithelial cells.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

3.

Single dose gentamicin treatment of urinary infections in children.

Author: GrimwoodK, AbbottG D, FergussonD M

UTI treatment

This study compared the effectiveness of a single dose of gentamicin to a seven-day course of antibiotics in treating 69 children with urinary tract infections. Both treatments resulted in similar outcomes after six weeks, regardless of the severity or history of infection. However, children with a history of recurrent infections or abnormal imaging were less likely to respond. The single dose treatment was associated with less disruption of the normal bacteria in the rectum and urethra. While patients who didn't respond to the single dose were more likely to experience a relapse, those who received the standard treatment were more likely to get a new infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Comparative study of first-line ceftriaxone and amikacin in the treatment of severe urinary tract infections in the adult].

Author: LepageJ Y, JugeC, CozianA, EspazeE, ReynaudA E, SouronR, BaronD

UTI treatment

A study of 40 patients with severe urinary tract infection found that ceftriaxone and amikacin were equally effective and well-tolerated as first-line treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

5.

[Comparative study of the treatment of simple urinary infection with a single dose of norfloxacin versus cotrimoxazole].

Author: de VeveyP, DarioliR, BilleJ, GlauserM P

UTI treatment

This study compared the effectiveness of a single dose of norfloxacin and cotrimoxazole in treating 53 women with uncomplicated urinary tract infections. Both antibiotics had similar success rates (85%) after one week. Both treatments were well-tolerated, with only minor side effects. Most treatment failures were due to gram-positive bacteria. The study concludes that single-dose therapy may be a viable option for treating urinary tract infections caused by gram-positive bacteria.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

6.

Long-term prophylaxis of urinary infections in women: comparative trial of trimethoprim, methenamine hippurate and topical povidone-iodine.

Author: BrumfittW, Hamilton-MillerJ M, GarganR A, CooperJ, SmithG W

Reduced colonization
Reduced infection incidence
Side effects

A study of 64 patients with frequent urinary tract infections compared three long-term preventative treatments: nightly trimethoprim, methenamine hippurate twice daily, and twice-daily perineal cleansing with povidone-iodine solution. All treatments effectively reduced the number of urinary tract infections compared to the year before treatment. While all treatments were effective, trimethoprim was better tolerated and reduced colonization of E. coli in the periurethral area. However, most breakthrough infections in the trimethoprim group were caused by trimethoprim-resistant bacteria, while this was less common in other groups. This study suggests that trimethoprim may be a good preventative option, but it’s important to be aware of the potential for developing resistant bacteria.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Role of cefotaxime in the treatment of urinary tract infections from the viewpoint of the urologist].

Author: PorpaczyP

Eradicated urinary tract infections
Recurrence of infections

A study of 153 patients with severe urinary tract infections found that cefotaxime was effective in treating the infection, with 138 patients showing no signs of the infection after treatment. However, the original bacteria reappeared in 20 patients and new bacteria were detected in 49 patients during follow-up.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

8.

A comparison of ceftazidime and tobramycin in the treatment of complicated urinary tract infections.

Author: CoxC E

High cure rates
Minimal side effects

A study of 62 patients with complicated urinary tract infections found that ceftazidime and tobramycin were equally effective in treating the infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Three-day treatment of acute lower urinary tract infections in women. A double-blind study with amoxycillin and co-trimazine.

Author: SigurdssonJ A, AhlménJ, BerglundL, JerneckM, LarssonL, LincolnK, WohrmA, BuchtH

Easy to administer
Effective UTI treatment
Few adverse reactions
Safe treatment
Nausea
Vomiting
Vulvovaginal irritation

A three-day course of amoxycillin or co-trimazine was effective in treating lower urinary tract infection (UTI) in women. Cure rates were 88% and 100% for amoxycillin and co-trimazine, respectively. Co-trimazine was more effective with a lower relapse rate (9% vs. 19%). Both treatments were safe with mild and infrequent side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A controlled trial of different treatment regimens in patients with urinary tract infections after lower urinary tract surgery.

Author: EvansC M, ClarkeT K, BarnoutiH, CrosbyA C, HolmesS, KulatilakeA E

Eradicated urinary tract infections

In a study of 104 people with urinary tract infections (UTIs) after catheterization or surgery, co-trimoxazole and cephradine were effective in treating the infections. Two doses of co-trimoxazole or cephradine per day for a week successfully eradicated 93% and 88% of the UTIs, respectively. However, four doses of cephradine per day were only successful in 64% of patients. E. coli and coagulase-negative staphylococci were the most common bacteria causing the UTIs. The effectiveness of the antibiotics did not always correlate with their sensitivity in lab tests.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Trimethoprim once daily vs. nitrofurantoin in treatment of acute urinary tract infections in young women, with special reference to periurethral, vaginal, and fecal flora.

Author: IravaniA, RichardG A, BaerH

Effective treatment
Well tolerated

Trimethoprim (TMP) and nitrofurantoin were both effective in treating acute urinary tract infections in women, with similar cure rates and tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Treatments for symptomatic urinary tract infections during pregnancy.

Author: VazquezJ C, VillarJ

Improved understanding of urinary tract infection treatment

Urinary tract infections, including kidney infections, are serious complications during pregnancy that can harm both the mother and baby. While there are many medications to treat these infections, most have been studied in women who are not pregnant. Determining the best treatment for pregnant women is difficult due to the lack of research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

A meta-analysis of randomized, controlled trials comparing short- and long-course antibiotic therapy for urinary tract infections in children.

Author: KerenRon, ChanEugenia

Effective treatment of UTIs
Concerns about occult pyelonephritis and renal scarring

Short-course antibiotics (1-3 days) are the standard treatment for acute urinary tract infections (UTIs) in adult women. While studies in children show no difference in effectiveness between short-course and longer-course (7-14 days) antibiotics, concerns about hidden kidney infections and scarring have led to recommendations for longer treatment in children.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Randomised controlled trial of nitrofurantoin versus placebo in the treatment of uncomplicated urinary tract infection in adult women.

Author: ChristiaensT C M, De MeyereM, VerschraegenG, PeersmanW, HeytensS, De MaeseneerJ M

UTI treatment effective

Nitrofurantoin is significantly more effective than placebo in achieving bacteriological cure and symptomatic relief in women with bacteriologically proven UTI.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Treatments for symptomatic urinary tract infections during pregnancy.

Author: VazquezJ C, VillarJ

Problematic to define optimal regimen for pregnancy

Urinary tract infections, including kidney infections, are serious complications during pregnancy that can harm both the mother and baby. While there are many medications to treat these infections, most have been studied in women who are not pregnant. Determining the best treatment for pregnant women is difficult due to the lack of research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Acute uncomplicated lower urinary tract infections in general practice: clinical and microbiological cure rates after three- versus five-day treatment with trimethoprim.

Author: van MerodeTiny, NysSita, RaetsInge, StobberinghEllen

UTI cure
Persistent symptoms

The relatively high percentage of persistent symptoms one day after the three-day regimen might be responsible for general practitioners believing that short regimens are not successful. It is therefore advisable that if urine samples are controlled to wait at least three days after finishing treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Cranberries for preventing urinary tract infections.

Author: JepsonR G, CraigJ C

UTI prevention
High dropout rate
Side effects

Cranberry juice may decrease the number of symptomatic UTIs over a 12 month period, particularly for women with recurrent UTIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

The diagnosis of urinary tract infection: a systematic review.

Author: SchmiemannGuido, KniehlEberhardt, GebhardtKlaus, MatejczykMartha M, Hummers-PradierEva

UTI treatment

Urinary tract infections (UTIs) are a major reason for seeking medical care and account for a large proportion of antibiotic use. Due to the frequency of UTIs and the increasing prevalence of antibiotic resistance, accurate diagnosis is essential to avoid overuse of antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Treatments for symptomatic urinary tract infections during pregnancy.

Author: VazquezJuan C, AbalosEdgardo

Urinary tract infection treatment

Urinary tract infections (UTIs), including kidney infections, pose significant risks to both mothers and babies during pregnancy. While many antibiotics are available, most have been studied in non-pregnant women. This makes it challenging to determine the best antibiotic treatment for pregnant women with UTIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

[National S3 guideline on uncomplicated urinary tract infection: recommendations for treatment and management of uncomplicated community-acquired bacterial urinary tract infections in adult patients].

Author: WagenlehnerF M E, SchmiemannG, HoymeU, FünfstückR, Hummers-PradierE, KaaseM, KniehlE, SelbachI, SesterU, VahlensieckW, WatermannD, NaberK G

UTI treatment

Urinary tract infections (UTIs) are very common, but increasing antibiotic resistance and the potential negative side effects of antibiotics have led to a need for updated treatment guidelines for uncomplicated UTIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

21.

Evaluation of the efficacy and safety of high dose short duration enrofloxacin treatment regimen for uncomplicated urinary tract infections in dogs.

Author: WestroppJ L, SykesJ E, IromS, DanielsJ B, SmithA, KeilD, SettjeT, WangY, ChewD J

Shorter treatment
Antimicrobial resistance

HDSD enrofloxacin treatment was not inferior to a conventional amoxicillin-clavulanic acid protocol for the treatment of uncomplicated bacterial UTI in dogs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Immediate versus conditional treatment of uncomplicated urinary tract infection - a randomized-controlled comparative effectiveness study in general practices.

Author: GágyorIldikó, Hummers-PradierEva, KochenMichael M, SchmiemannGuido, WegscheiderKarl, BleidornJutta

Reduced antibiotic use

This study investigates whether antibiotic use for uncomplicated urinary tract infections (UTIs) can be reduced by initially treating with ibuprofen, reserving antibiotics for patients with persistent or recurrent symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

α1-Blockers for the treatment of recurrent urinary tract infections in women with dysfunctional voiding: a prospective randomized study.

Author: MinardiDaniele, PellegrinelliFrancesco, ContiAlessandro, FontanaDonatella, MattiaMichela, MilaneseGiulio, MuzzonigroGiovanni

UTI reduction
Urinary symptom improvement

Tamsulosin associated with uroflowmetry biofeedback might be an effective and safe treatment option for improving urinary symptoms and quality of life in women with dysfunctional voiding and recurrent urinary tract infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Chinese herbal medicine for treating recurrent urinary tract infections in women.

Author: FlowerAndrew, WangLi-Qiong, LewithGeorge, LiuJian Ping, LiQing

CHM for UTI
Microbial resistance
Side effects

This review examines the potential of Chinese herbal medicine (CHM) for treating recurrent urinary tract infections (UTIs) in women. While prophylactic antibiotics are common, there are concerns about resistance and side effects. The review explores the potential role of CHM as an alternative treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Asymptomatic bacteriuria treatment is associated with a higher prevalence of antibiotic resistant strains in women with urinary tract infections.

Author: CaiTommaso, NesiGabriella, MazzoliSandra, MeacciFrancesca, LanzafamePaolo, CaciagliPatrizio, MereuLiliana, TateoSaverio, MalossiniGianni, SelliCesare, BartolettiRiccardo

Antibiotic resistance

This study examines the impact of treating asymptomatic bacteriuria (AB) on antibiotic resistance in women with recurrent urinary tract infections (rUTIs). The study aims to understand the potential consequences of treating AB for antibiotic resistance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Standardised Chinese herbal treatment delivered by GPs compared with individualised treatment administered by practitioners of Chinese herbal medicine for women with recurrent urinary tract infections (RUTI): study protocol for a randomised controlled trial.

Author: FlowerAndrew, HarmanKim, LewithGeorge, MooreMichael, BishopFelicity L, StuartBeth, LampertNicholas

Alleviate UTI symptoms
Reduce recurrence rate

This review explored the potential of Chinese herbal medicine (CHM) in treating urinary tract infections (UTIs) and recurrent urinary tract infections (RUTIs) in women, highlighting the need for further research to confirm preliminary evidence of CHM's effectiveness.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Optimal dosage and duration of pivmecillinam treatment for uncomplicated lower urinary tract infections: a systematic review and meta-analysis.

Author: PinartMariona, KranzJennifer, JensenKatrin, ProctorTanja, NaberKurt, KunathFrank, WagenlehnerFlorian, SchmidtStefanie

Effective UTI treatment
Adverse events

This meta-analysis of 24 randomized controlled trials found insufficient evidence to support the use of an optimal combination of dosage, frequency, and duration of pivmecillinam therapy for uncomplicated lower urinary tract infections (UTIs). No significant difference in clinical cure was found between different dosage regimens. Although higher dosages tended to improve bacteriological cure, the results were not statistically significant. Patients treated with high dosages were more likely to report mild to moderate adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Role Of Symptomatic Treatment In Comparison To Antibiotics In Uncomplicated Urinary Tract Infections.

Author: JamilMuhammad Nasir, FarooqUmer, SultanBabar, KhanRaza Muhammad

UTI treatment

Uncomplicated urinary tract infections (UTIs) are common in women, but antibiotic resistance is a growing problem. This study compared treating UTIs with symptom relief only versus antibiotics, looking at how well each approach relieved symptoms like frequent urination, urgency, pain, and overall discomfort.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients. Part II: Therapy and Prevention.

Author: KranzJennifer, SchmidtStefanie, LebertCordula, SchneidewindLaila, MandrakaFalitsa, KunzeMirjam, HelbigSina, VahlensieckWinfried, NaberKurt, SchmiemannGuido, WagenlehnerFlorian M

Improved UTI treatment

This is the second part of an updated guideline on the diagnosis and treatment of uncomplicated urinary tract infections (UTIs) in adults. The first part covered general methods, patient groups, and diagnostic approaches. This part focuses on treatments for bladder infections (cystitis) and kidney infections (pyelonephritis), as well as preventing recurrent UTIs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Risk Factors for Delayed Antimicrobial Treatment in Febrile Children with Urinary Tract Infections.

Author: HumStephanie W, ShaikhNader

Delayed treatment
Renal scarring

A study of 660 children with urinary tract infection (UTI) found that older age was a consistent predictor of delayed antimicrobial treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

31.

Procalcitonin, mid-regional proadrenomedullin and C-reactive protein in predicting treatment outcome in community-acquired febrile urinary tract infection.

Author: StalenhoefJanneke Evelyne, van NieuwkoopCees, WilsonDarius Cameron, van der StarreWillize Elizabeth, van der ReijdenTanny J K, DelfosNathalie Manon, LeytenEliane Madeleine Sophie, KosterTed, AblijHans Christiaan, van 't WoutJohannes Jan Willem, van DisselJaap Tamino

Improved fUTI treatment

Minimizing the duration of antibiotic therapy is essential to reduce antimicrobial resistance, drug-related side effects, and healthcare costs. This review explores the optimal duration of antibiotic therapy for febrile urinary tract infections (fUTI), especially in males, older adults, and those with comorbidities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study.

Author: WadeDerick, CooperJames, DerryFadel, TaylorJulian

Reduced UTI risk

Recurrent urinary tract infections (UTIs) are common in patients with lower neurogenic bladder dysfunction. This study highlights the need for research on alternative preventive measures to reduce the reliance on antibiotics, which can contribute to antibiotic resistance.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Prevention and treatment of uncomplicated lower urinary tract infections in the era of increasing antimicrobial resistance-non-antibiotic approaches: a systemic review.

Author: WawrysiukSara, NaberKurt, RechbergerTomasz, MiotlaPawel

Non-antibiotic options
UTI prevention and treatment

Urinary tract infections (UTIs) are common, affecting women 14 times more often than men. Because UTIs are often caused by bacteria, antibiotics are frequently used, but this has led to increased resistance to antibiotics. New non-antibiotic prevention and treatment options are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? Protocol for a feasibility study.

Author: GbinigieOghenekome, AllenJulie, BoylanAnne-Marie, HayAlastair, HeneghanCarl, MooreMichael, WilliamsNicola, ButlerChris

UTI treatment

Many people seek medical care for urinary tract infection (UTI) symptoms, often receiving antibiotics. As antibiotic resistance is a growing concern, interest in non-antibiotic options like cranberry extract is increasing. This study examines the potential use of cranberry extract for treating UTI symptoms.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Efficacy and safety of quinolones for the treatment of uncomplicated urinary tract infections in women: a network meta-analysis.

Author: González-GarayAlejandro, Velasco-HidalgoLiliana, Ochoa-HeinEric, Rivera-LunaRoberto

Improved uUTI treatment

This study aimed to find the best quinolone antibiotic treatment for uncomplicated urinary tract infections (UTIs) in women. They reviewed existing research and conducted a meta-analysis to compare different quinolone regimens and determine which were most effective and safe. The goal was to identify the optimal treatment for this common condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial.

Author: LeitnerLorenz, UjmajuridzeAleksandre, ChanishviliNina, GoderdzishviliMarina, ChkoniaIrina, RigvavaSophia, ChkhotuaArchil, ChangashviliGiorgi, McCallinShawna, SchneiderMarc P, LiechtiMartina D, MehnertUlrich, BachmannLucas M, SybesmaWilbert, KesslerThomas M

Bacteriophage therapy for UTI

This study investigates the effectiveness of intravesical bacteriophage therapy with a commercial bacteriophage cocktail for treating urinary tract infections (UTIs), addressing the increasing concern of antibiotic resistance.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Treatment of UTIs in Infants <2 Months: A Living Systematic Review.

Author: NamaNassr, DonkenRobine, PawliukColleen, LeacheLeire, SadaranganiManish, CarwanaMatthew,

Reduced UTI recurrence

This living systematic review compared the duration of parenteral antibiotics for urinary tract infections in infants <2 months of age. Short and long durations were associated with similar risks of recurrence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Efficacy of antimicrobial intravesical treatment for uncomplicated recurrent urinary tract infections: a systematic review.

Author: ReddyMeghana, ZimmernPhilippe E

UTI reduction
Drug resistance

This systematic review investigated the efficacy of intravesical antimicrobials (IVA) for the management of uncomplicated recurrent urinary tract infections (rUTIs). Gentamicin and hyaluronic acid IVA were found to be effective in reducing UTI frequency, with dosages of 80 mg gentamicin and 40 or 800 mg hyaluronic acid per instillation being most effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Short Intravenous Antibiotic Courses for Urinary Infections in Young Infants: A Systematic Review.

Author: HikmatSamar, LawrenceJolie, GweeAmanda

Shorter IV antibiotic courses

This systematic review investigated the optimal duration of intravenous (IV) antibiotic treatment for urinary tract infections (UTIs) in infants aged ≤90 days. The study found that shorter IV antibiotic courses of ≤7 days and ≤3 days with early switch to oral antibiotics were appropriate for bacteremic and nonbacteremic UTIs, respectively. Further research is needed to evaluate the safety and effectiveness of oral antibiotics alone for UTIs in this age group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Original Article Phytotherapy in Adults With Recurrent Uncomplicated Cystitis.

Author: KranzJennifer, LacknerJulia, KünzelUlrike, WagenlehnerFlorian, SchmidtStefanie

Reduced cystitis recurrence

This systematic review investigates the use of phytotherapy for the treatment and prevention of recurrent uncomplicated cystitis. This review highlights the growing interest in alternative, non-antimicrobial therapies for urinary tract infections (UTIs) due to rising antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Association of Kidney Stones and Recurrent UTIs: the Chicken and Egg Situation. A Systematic Review of Literature.

Author: RipaFrancesco, PietropaoloAmelia, MontanariEmanuele, HameedB M Zeeshan, GauharVineet, SomaniBhaskar K

UTI resolution with stone removal
Recurrent UTI
Stone formation

Kidney stone disease (KSD) and recurrent urinary tract infections (rUTI) are strongly associated and may be mutually causal. Surgical clearance of kidney stones often resolves rUTIs, but recurrence rates remain uncertain. Proactive stone removal is recommended, especially in cases of recurrent UTIs or additional risk factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections.

Author: SalvatoreStefano, RuffoloAlessandro Ferdinando, StabileGuglielmo, CasiraghiArianna, ZitoGabriella, De SetaFrancesco

Safe
UTI treatment

A randomized, double-blind, placebo-controlled trial evaluated the safety and efficacy of a D-mannose-based dietary supplement (DAPAD complex) for treating uncomplicated acute E. coli UTIs in nonmenopausal women. The DAPAD complex group showed significantly higher clinical resolution and bacteriological resolution at day 6 and day 35 compared to the placebo group. The DAPAD complex was well tolerated, with only three mild adverse events recorded.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

[Combined therapy of patients with recurrent cystitis using a complex of natural antimicrobial peptides and cytokines: first results].

Author: KulchavenyaE V, NeymarkA I, TcukanovA Yu, PluginP S, NeymarkA B, RazdorskayaM V

Cystitis treatment
Microcirculation improvement

Etiopathogenetic therapy, including Superlymph rectal suppositories, significantly improved the results of combination therapy for chronic cystitis, with longer-term use of Superlymph rectal suppositories at a reduced dosage (10 units) showing superiority.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

44.

[Chronic cystitis: how to prolong the relapse-free period?]

Author: KulchavenyaE V, NeimarkA I, TsukanovA Yu, NeimarkA B, RazdorskayaM V

Reduced cystitis recurrence

Combined antibiotic therapy with Superlymph rectal suppositories significantly reduced the number of recurrences and prolonged the relapse-free period in patients with chronic cystitis.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.