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Development of a Δ9-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability.
Author: AdelliGoutham R, BhagavPrakash, ElSohlyMahmoud A, GulWaseem, HingoraniTushar, MajumdarSoumyajit, PettawaySara, RepkaMichael A, TaskarPranjal
Original Abstract of the Article :
The aim of the present study was to evaluate the utility of the relatively hydrophilic Δ9-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC-Val-Val) and the amino acid (valine)-dicarboxylic acid (hemisuccinate) ester (THC-Val-HS), with respect to ocular penetration and ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389743/
データ提供:米国国立医学図書館(NLM)
A New Approach to Eye Care: Developing THC Prodrugs for Ocular Delivery
This research delves into the world of ocular drug delivery, aiming to develop more effective ways to deliver medications to the eye. It's like navigating a desert, where the delicate balance of the environment must be carefully considered for any intervention to succeed. The study focuses on developing prodrugs of Δ9-tetrahydrocannabinol (THC), a psychoactive compound found in cannabis, to enhance their ocular bioavailability. This approach holds promise for treating various eye conditions, including glaucoma, where improving drug penetration into the eye is crucial.
Improving Ocular Bioavailability: THC Prodrugs for Eye Care
This research explores the potential of THC prodrugs for ocular drug delivery. It's like seeking a hidden oasis in the desert, where innovation is needed to reach a valuable destination. The researchers investigated the effectiveness of different THC prodrugs in enhancing the delivery of THC to the eye, measuring their ability to penetrate the eye and lower intraocular pressure (IOP), a key factor in glaucoma. The study highlights the potential of this approach for developing new and improved treatments for eye diseases.
A Promising Future for Eye Care: THC Prodrugs Offer New Solutions
This research opens up new possibilities for treating eye conditions. It's like finding a fertile oasis in a barren desert – a promising development that could significantly impact the lives of many. The study demonstrates the potential of THC prodrugs to enhance drug delivery to the eye, offering hope for improving the treatment of various eye diseases, including glaucoma.
Dr. Camel's Conclusion
This study explores the potential of THC prodrugs for ocular drug delivery. It's like finding a new route through the desert – a promising approach that could lead to better treatments for eye conditions.
Date :
- Date Completed 2017-06-26
- Date Revised 2022-03-31
Further Info :
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