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Comparison of the immunogenicity and safety of the purified chick embryo cell rabies vaccine manufactured in India and Germany: A randomized, single blind, multicentre, phase IV clinical study.

Author: AroraAshwani Kumar, BanzhoffAngelika, DeshpandeAlaka, MalerczykClaudius, PreissScott, SampathGadey, VakilHoshang

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compares the immunogenicity and safety of India-manufactured purified chick embryo cell rabies vaccine (PCECV-I) with a German-manufactured batch (PCECV-G). All batches induced comparable immune responses and safety profiles when administered according to a 5-dose schedule. The study confirms the effectiveness and safety of the Indian-manufactured PCECV.
Paper Details　
Original Abstract of the Article :
This phase IV, single blind study assessed the immunogenicity and safety of India-manufactured purified chick embryo cell rabies vaccine (PCECV), compared with a German-manufactured batch obtained by the same production process. A total of 340 participants enrolled at 2 study sites in India were ran...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512782/

データ提供：米国国立医学図書館（NLM）

The Global Reach of Rabies Vaccination: Comparing Immunogenicity and Safety Across Continents

This research delves into the crucial realm of rabies vaccination, a vital tool for protecting against this deadly virus. Imagine a global network of travelers, each venturing into diverse landscapes, some more treacherous than others. This research examines the effectiveness and safety of rabies vaccines produced in different parts of the world, ensuring that all travelers are adequately protected. The authors compared the immunogenicity and safety profiles of rabies vaccines manufactured in India and Germany.

A Global Shield: Ensuring Effective Rabies Protection

This study, like a global network of healthcare providers, is committed to ensuring effective rabies protection for all. The authors found that both Indian and German-manufactured rabies vaccines induced similar immune responses and exhibited comparable safety profiles. This reassuring discovery signifies that individuals, no matter where they are in the world, can access a safe and effective vaccine to protect them from this deadly disease.

A Global Effort: Collaboration for Healthier Futures

This research emphasizes the importance of collaboration and standardization in the development and distribution of vaccines. Just as a network of desert oases provides water and sustenance for travelers, collaboration between different countries and research institutions ensures that everyone has access to vital healthcare resources. This study demonstrates how sharing knowledge and resources can lead to a healthier and safer world.

Dr. Camel's Conclusion

This research underscores the critical importance of effective and readily available rabies vaccines for individuals worldwide. Like a network of desert oases providing safe haven for travelers, these vaccines offer a vital shield against this deadly virus. This study highlights the global effort to protect human health and the importance of collaboration in achieving this crucial goal.
Date :
  1. Date Completed 2018-03-14
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28406752

DOI: Digital Object Identifier

PMC5512782

Related Literature

Article Analysis
・Side Effects of rabies vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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