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Effectiveness of a live oral human rotavirus vaccine after programmatic introduction in Bangladesh: A cluster-randomized trial.

Author: ArifeenShams El, AzimTasnim, CraviotoAlejandro, FellerAndrea J, FlemingJessica A, HalloranM Elizabeth, HossainIlias, LewisKristen D C, MoultonLawrence H, NeuzilKathleen M, QadriFirdausi, RahmanMustafizur, SackDavid A, SugimotoJonathan D, VictorJohn C, YunusMohammad, ZamanK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examines the effectiveness of a two-dose schedule of the human rotavirus vaccine (HRV; Rotarix) given early in infancy. While rotavirus vaccines are globally recommended, WHO concluded in 2009 that there was no evidence for the efficacy or effectiveness of this schedule. The study highlights the need for further research, particularly in low-resource populations in Asia.
Paper Details　
Original Abstract of the Article :
Rotavirus vaccines are now globally recommended by the World Health Organization (WHO), but in early 2009 WHO's Strategic Advisory Group of Experts on Immunization reviewed available data and concluded that there was no evidence for the efficacy or effectiveness of a two-dose schedule of the human r...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395158/

データ提供：米国国立医学図書館（NLM）

Evaluating the Effectiveness of a Live Oral Human Rotavirus Vaccine in Bangladesh

Rotavirus infection is a significant cause of diarrhea in infants and young children worldwide, particularly in developing countries. This study investigates the effectiveness of a live oral human rotavirus vaccine (HRV) after its programmatic introduction in Bangladesh. The researchers employed a cluster-randomized trial to assess the vaccine's impact on rotavirus disease incidence, highlighting the importance of evaluating vaccine efficacy and effectiveness in real-world settings, particularly in resource-limited populations.

Vaccines: A Lifeline in the Desert of Disease

Vaccines play a crucial role in preventing infectious diseases, acting as a lifeline in the desert of human health. This study underscores the importance of evaluating vaccine effectiveness in diverse settings, particularly in resource-limited populations where the burden of infectious diseases is often greatest.

Protecting Children from Rotavirus

Rotavirus vaccination is a critical tool in the fight against this debilitating disease. By understanding the effectiveness of vaccines in different settings, we can work towards achieving optimal protection for children worldwide. This research highlights the importance of continuous monitoring and evaluation of vaccination programs to ensure their effectiveness and maximize their impact.

Dr.Camel's Conclusion

This study underscores the vital role of vaccines in protecting children from rotavirus infection. The findings highlight the importance of evaluating vaccine effectiveness in different contexts, particularly in resource-limited populations. As a camel navigating a vast desert, we must continually strive to find solutions that improve the health and well-being of all individuals, especially the most vulnerable among us.

Date :
  1. Date Completed 2017-05-01
  2. Date Revised 2019-02-02
Further Info :

Pubmed ID

28419095

DOI: Digital Object Identifier

PMC5395158

Related Literature

Article Analysis
・Effects of rotavirus vaccine
SNS
PICO Info
in preparation
Languages

English

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