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Effect of Topical Iloprost and Nitroglycerin on Gastric Microcirculation and Barrier Function during Hemorrhagic Shock in Dogs.

Author: BauerInge, HerminghausAnna, HinterbergJonas, Mettler-AltmannTabea, PickerOlaf, SchulzJan, TruseRichard, VollmerChristian, WeberAndreas

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of locally applied iloprost and nitroglycerin on gastric mucosal perfusion, oxygenation, and barrier function during physiological and hemorrhagic conditions. The study found that both iloprost and nitroglycerin improved regional gastric oxygenation without affecting perfusion, and that nitroglycerin attenuated the shock-induced impairment of the mucosal barrier integrity. This suggests that local drug application may be a useful strategy for improving gastric microcirculation and protecting mucosal barrier function during hemorrhagic conditions.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Topical drug application is used to avoid systemic side effects. The aim of this study was to analyze whether locally applied iloprost or nitroglycerin influence gastric mucosal perfusion, oxygenation, and barrier function during physiological and hemorrhagic conditions. METHODS: In rep...See full text at original site
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引用元：
https://doi.org/10.1159/000464262

データ提供：米国国立医学図書館（NLM）

Protecting the Gastric Mucosa: A Topical Approach

Greetings from Dr. Camel! This research delves into the fascinating world of topical drug application, exploring its potential to protect the delicate gastric mucosa. It's like a desert traveler, seeking to shield themselves from the harsh elements. The study focuses on the effects of topical iloprost and nitroglycerin on gastric microcirculation and barrier function during physiological and hemorrhagic conditions.

Topical Delivery: A Targeted Approach

Topical drug application is a promising approach to target specific areas of the body while minimizing systemic side effects. It's like a carefully aimed arrow, hitting the target with precision. This study explores the potential of topical iloprost and nitroglycerin to protect the gastric mucosa during hemorrhagic shock, a serious condition that compromises blood flow and oxygenation.

A Beacon of Hope

The study finds that topical nitroglycerin and iloprost improve regional gastric oxygenation during hemorrhagic shock, offering a ray of hope for protecting the delicate gastric lining. It's like a desert oasis, providing much-needed relief in a challenging situation. Furthermore, nitroglycerin is shown to enhance the integrity of the mucosal barrier, further protecting the stomach from damage.

Dr. Camel's Conclusion

This study presents a promising approach to protecting the gastric mucosa during challenging conditions. It highlights the potential of topical drug delivery to provide targeted relief, minimizing systemic side effects and improving outcomes for patients. It's a journey through the desert of medical research, seeking out innovative solutions to protect the body from harm.

Date :
  1. Date Completed 2017-06-19
  2. Date Revised 2018-06-09
Further Info :

Pubmed ID

28441653

DOI: Digital Object Identifier

10.1159/000464262

Related Literature

Article Analysis
・Side Effects of iloprost
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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