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Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy.

Author: BragazziNicola Luigi, BrigoFrancesco, IgweStanley C

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Stiripentol (STP) was significantly better than placebo in reducing seizure frequency and achieving seizure freedom in patients with severe myoclonic epilepsy in infants (SMEI). Adverse effects occurred more frequently with STP.
Paper Details　
Original Abstract of the Article :
BACKGROUND: This is an updated version of the original Cochrane review published in 2015, Issue 10.Severe myoclonic epilepsy in infants (SMEI), also known as Dravet syndrome, is a rare, refractory form of epilepsy, for which stiripentol (STP) has been recently licensed as add-on therapy. OBJECTIVES...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481545/

データ提供：米国国立医学図書館（NLM）

Antiepileptic Drugs for Infants with Severe Myoclonic Epilepsy: A Journey Through the Desert of Treatment Options

The treatment of [severe myoclonic epilepsy in infants (SMEI)], also known as [Dravet syndrome], is a complex and often challenging journey, with limited options available for effectively managing seizures. This study explores the use of [antiepileptic drugs (AEDs)] for [SMEI], examining the efficacy and tolerability of [stiripentol (STP)] and other potential treatment options, including the [ketogenic diet].

The researchers reviewed two randomized controlled trials that evaluated the use of [STP] in [SMEI] patients. These studies found that [STP] was significantly more effective than [placebo] in reducing seizure frequency and achieving seizure freedom. However, [STP] was also associated with a higher incidence of [adverse effects] compared to [placebo].

The study highlights the need for further research to definitively establish the long-term efficacy and safety of [STP] in the treatment of [SMEI]. It also underscores the importance of considering other potential treatment options, such as the [ketogenic diet], in patients who do not respond to [STP] or who experience unacceptable side effects.

Stiripentol: A Potential Oasis in the Desert of SMEI Treatment

This study suggests that [stiripentol] may be a valuable addition to the treatment options for [SMEI], offering potential benefits in reducing seizure frequency and achieving seizure freedom. However, it's important to weigh the potential benefits against the risks of side effects and to explore other treatment options when necessary.

Dr.Camel's Conclusion

The desert of [severe myoclonic epilepsy in infants] is a challenging landscape for both patients and their families. This study offers a glimmer of hope in the form of [stiripentol], which shows potential for reducing seizure frequency and achieving seizure freedom. However, like a mirage, the promise of a cure needs to be approached with caution and further exploration is needed to understand the long-term implications of this treatment option.

Date :
  1. Date Completed 2017-08-09
  2. Date Revised 2022-02-16
Further Info :

Pubmed ID

28521067

DOI: Digital Object Identifier

PMC6481545

Related Literature

Article Analysis
・Side Effects of stiripentol
SNS
PICO Info
in preparation
Languages

English

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