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Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice.

Author: FujitaMasataka, IrieJunichiro, ItohArata, ItohHiroshi, IwabuKaho, KatoMari, KawaiToshihide, KikuchiRieko, KobayashiNana, KusumotoYukie, MorimotoKohkichi, NakajimaYuya, OikeYuichi, SugizakiTaichi, TagawaHirotsune, TanakaKumiko, WatanabeMitsuhiro, YamadaSatoru

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Bile acid binding resin (BAR) is a medication that has been shown to be effective in treating obesity and metabolic disorders. This study investigated the effect of BAR on intestinal microbiota in mice.
Paper Details　
Original Abstract of the Article :
Bile acid binding resin (BAR) absorbs intestinal bile acids, and improves obesity and metabolic disorders, but the precise mechanism remains to be clarified. Recent findings reveal that obesity is associated with skewed intestinal microbiota. Thus, we investigated the effect of BAR on intestinal mic...See full text at original site
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引用元：
https://doi.org/10.1016/j.metabol.2017.02.011

データ提供：米国国立医学図書館（NLM）

Bile Acid Binding Resin: A Gut-Friendly Approach to Fighting Obesity

This research focuses on the role of bile acid binding resin (BAR) in preventing fat accumulation and improving metabolic disorders in mice with high-fat diet-induced obesity. The authors investigate the impact of BAR on intestinal microbiota and its contribution to the prevention of obesity. The study reveals that BAR's beneficial effects on obesity may be mediated through its influence on the gut microbiome, highlighting the intricate connection between our gut health and overall well-being.

Bile Acid Binding Resin: A Gut Microbiome Modulator

This study delves into the fascinating world of the gut microbiome and its influence on obesity. The researchers discovered that BAR, a medication used to treat high cholesterol, exerts its beneficial effects on obesity by altering the composition of the gut microbiota. This finding opens up new avenues for exploring the role of the gut microbiome in metabolic health and developing novel approaches to combat obesity.

Balancing the Gut Microbiome: A Key to Metabolic Health

The study's findings underscore the crucial role of the gut microbiome in maintaining metabolic health. By promoting a healthy balance of gut bacteria, BAR may help prevent fat accumulation and improve metabolic disorders. This understanding highlights the importance of focusing on gut health as a vital component of overall well-being.

Dr.Camel's Conclusion

This study, like a refreshing oasis in the desert of obesity research, highlights the intricate connection between the gut microbiome and metabolic health. The researchers demonstrate that BAR, by influencing the composition of the gut microbiota, can play a significant role in preventing fat accumulation and improving metabolic disorders. This study encourages us to explore the vast and complex world of the gut microbiome, seeking to unlock its secrets for improving human health.
Date :
  1. Date Completed 2017-08-14
  2. Date Revised 2018-03-14
Further Info :

Pubmed ID

28521862

DOI: Digital Object Identifier

10.1016/j.metabol.2017.02.011

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Languages

English

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