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Surgery for cure followed by combined modality treatment for small cell bronchial carcinoma. ISC Lung Cancer Study Group.

Author: Dell'AmoreD, DenckH, DringsP, ErzenJ, Karnicka-MlodkowskaH, KarrerK, LiaoM L, SalzerG M, SunY, ThermannM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the treatment outcomes for 121 patients with early-stage small cell lung cancer (SCLC). Patients underwent surgery to remove the primary tumor and lymph nodes, followed by either standard chemotherapy or a sequential chemotherapy regimen. The study found that 3-year survival rates were 65% for stage pT1-3 N0 M0, 56% for stage pT1-3 N1 M0, and 34% for stage pT1-3 N2 M0. While surgery is generally recommended for stages I and II, surgery for stage N2 lesions might be beneficial compared to chemotherapy or radiation alone. The study emphasizes the need for larger, multi-center studies to further investigate the role of surgery and chemotherapy for SCLC.
Paper Details　
Original Abstract of the Article :
For patients with small cell lung cancer (SCLC) at early stages (TNM I, II) surgery for cure is used to eliminate the primary tumour and its regional lymph-nodes followed by intermittent chemotherapy and radiotherapy within the first six postoperative months. After the pathohistological examination ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2855325

データ提供：米国国立医学図書館（NLM）

Small Cell Lung Cancer: A Multifaceted Approach to Treatment

Small cell lung cancer (SCLC), an aggressive form of lung cancer, presents a complex and challenging landscape for clinicians. This research explores the potential of a combined modality approach, involving surgery, chemotherapy, and radiotherapy, for patients with early-stage SCLC. The authors describe a clinical trial protocol for patients with TNM I and II SCLC, where surgery is followed by intermittent chemotherapy and radiotherapy. Their findings suggest that this combined modality approach can lead to favorable survival outcomes in early-stage SCLC. The study highlights the importance of multidisciplinary care and individualized treatment plans for optimizing outcomes in this challenging disease.

Combined Modality Treatment: A Multifaceted Approach to Combatting SCLC

The study demonstrates that a combined modality approach, involving surgery, chemotherapy, and radiotherapy, can be an effective strategy for treating early-stage SCLC. The findings highlight the potential of this approach to improve survival outcomes and enhance the quality of life for patients with this aggressive form of cancer. Further research is needed to refine this approach and optimize treatment strategies for different stages and patient characteristics.

Navigating the Desert of Lung Cancer Treatment: Finding the Right Path

The desert of lung cancer treatment is vast and complex, requiring a multifaceted approach to address the diverse needs of patients. This study highlights the potential of combined modality treatment for early-stage SCLC, emphasizing the importance of multidisciplinary care and individualized treatment plans. By working together, healthcare professionals and patients can navigate this challenging terrain and find the right path toward optimal outcomes.

Dr. Camel's Conclusion

Small cell lung cancer presents a formidable challenge, but this study offers a glimmer of hope. The combined modality approach involving surgery, chemotherapy, and radiotherapy can be an effective strategy for early-stage SCLC. By embracing a multidisciplinary approach and tailoring treatment plans to individual patient needs, we can find our way through the desert of lung cancer and towards better outcomes.

Date :
  1. Date Completed 1989-08-18
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

2855325

DOI: Digital Object Identifier

2855325

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・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

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