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Effects of DNase I coating of titanium on bacteria adhesion and biofilm formation.

Author: CenYunzhu, GaoPing, GuoXuyun, LiuYing, MaShiqing, ShaoCan, YeJing, ZhangXu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the immobilization of DNase I, a biofilm-dispersing enzyme, on a titanium (Ti) surface using dopamine as an intermediate. The DNase I coating effectively prevented Streptococcus mutans and Staphylococcus aureus adhesion and biofilm formation on the Ti surface, demonstrating its potential for preventing implant-associated infections.
Paper Details　
Original Abstract of the Article :
The removal of mature biofilm from the surface of implant has been a formidable challenge in treating implant-associated infection. Prevention of biofilm formation rather than removal of existing biofilm is a more effective approach. Immobilization of biofilm-dispersing enzymes on material surfaces ...See full text at original site
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引用元：
https://doi.org/10.1016/j.msec.2017.04.078

データ提供：米国国立医学図書館（NLM）

Fighting Biofilm Formation on Implants

This research addresses a critical challenge in implant surgery – the prevention of bacterial biofilm formation, which can lead to implant-associated infections. The study explores the potential of immobilizing deoxyribonuclease I (DNase I) on titanium surfaces, aiming to prevent bacterial adhesion and biofilm formation.

A Biofilm-Busting Strategy

DNase I coating demonstrated significant effects in preventing bacterial adhesion and biofilm formation, highlighting the potential of this approach for reducing implant-associated infections. The study also demonstrated the biocompatibility of the DNase I coating, suggesting its potential for safe and effective application in clinical settings.

A Shield Against Infection

This research, like building a protective sandcastle against the encroaching tide, explores a novel strategy for preventing biofilm formation on implants. The findings offer a promising approach for enhancing implant success rates and reducing the risk of implant-associated infections.

Dr.Camel's Conclusion

This study explores a promising approach for preventing biofilm formation on implants, creating a protective shield against infection. Just as a sturdy sandcastle can withstand the tide, this innovative strategy has the potential to enhance implant success rates and reduce the risk of complications.

Date :
  1. Date Completed 2018-03-14
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28576044

DOI: Digital Object Identifier

10.1016/j.msec.2017.04.078

Related Literature

Article Analysis
・Effects of dnase
SNS
PICO Info
in preparation
Languages

English

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