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A comparative trial of the antidepressant, anxiolytic, and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients.

Author: AssalianP, PhillipsR, RosengartenM D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Trimipramine and doxepin both improved overall well-being in hospitalized depressed patients. Trimipramine showed superior effects in reducing sleep disturbance, diurnal variation, and somatic symptoms. Doxepin was associated with more side effects.
Paper Details　
Original Abstract of the Article :
After a 1-week placebo washout, 25 depressed hospitalized patients were treated for 4 weeks with trimipramine or doxepin in a fixed equivalent dosage schedule ending in 150 mg h.s. The study used a parallel group double-blind design. Comparisons over time revealed that both drugs improved patients' ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2857709

データ提供：米国国立医学図書館（NLM）

Trimipramine and Doxepin: Comparing Antidepressant Effects

Depression is a complex mental health disorder, and finding effective treatments can be a challenging journey. This study compared the antidepressant, anxiolytic (anxiety-reducing), and cardiovascular effects of two medications, trimipramine and doxepin, in hospitalized patients with depression. Think of it like comparing two different types of compasses guiding travelers through a vast desert - one compass might be more accurate or reliable than the other. The researchers wanted to see which medication offered the most effective guidance in navigating depression.

Trimipramine: Showing Promise

The study found that both trimipramine and doxepin showed improvement in overall well-being, but trimipramine consistently outperformed doxepin in several areas, including reducing anxiety symptoms, improving sleep quality, and showing a more rapid improvement in overall well-being. It's like having a compass that accurately points towards a hidden oasis, leading to a faster and more effective journey.

Navigating Depression: Choosing the Right Treatment

This study provides valuable insights into the treatment of depression. It's important to work with a healthcare professional to find the most appropriate treatment for your individual needs. Just as a camel adapts its journey to the terrain, finding the right treatment for depression is crucial for achieving long-term well-being.

Dr. Camel's Conclusion

This study underscores the importance of finding the right treatment for depression, just as a camel chooses the right path through the desert. It highlights the need for continued research to develop more effective and personalized treatment approaches, leading to a brighter future for individuals facing depression.

Date :
  1. Date Completed 1985-04-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2857709

DOI: Digital Object Identifier

2857709

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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