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Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers.

Author: BernsteinHilary, JohnsonHeather J, KnightJoshua M, MalcolmRobert J, MarkowitzJohn S, PatrickKennerly S, ReevesOwen T, ShiJian, SmithAaron T, StraughnArthur B, ZhuHao-Jie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the interactions between ethanol and methylphenidate (MPH) formulations. The study found that ethanol significantly increases the maximum plasma concentration (Cmax) of d-MPH and overall drug exposure, potentially due to acceleration of MPH formulation gastric dissolution by ethanol.
Paper Details　
Original Abstract of the Article :
Ethanol coadministered with immediate-release dl-methylphenidate (dl-MPH) or dexmethylphenidate (d-MPH) significantly increases the geomean maximum plasma concentration (Cmax) of d-MPH 22% and 15%, respectively, and elevates overall drug exposure and psychostimulant effects. We asked the question: A...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/28590363

データ提供：米国国立医学図書館（NLM）

The Impact of Ethanol on Methylphenidate Absorption

The [pharmacokinetics of methylphenidate] is an important consideration in the treatment of [attention-deficit/hyperactivity disorder (ADHD)]. This study investigates the [interaction between ethanol and methylphenidate] using [spheroidal oral drug absorption systems] in healthy volunteers. The authors found that [ethanol coadministration] significantly [increased the maximum plasma concentration and overall drug exposure] of [dexmethylphenidate]. These findings suggest that [ethanol consumption] can potentially [alter the pharmacokinetics and pharmacodynamics] of methylphenidate, potentially leading to [unintended effects] in patients with ADHD.

Navigating the Desert of Drug Interactions

The desert of drug interactions can be a treacherous landscape, filled with potential pitfalls that can alter the effectiveness and safety of medications. This research underscores the importance of considering the potential impact of [ethanol consumption] on the pharmacokinetics of methylphenidate. By understanding these interactions, healthcare providers can better navigate this challenging terrain, ensuring optimal treatment outcomes for patients with ADHD.

A Warning Sign in the Desert of ADHD Treatment

This research provides a warning sign in the desert of ADHD treatment, highlighting the potential for ethanol to alter the pharmacokinetics of methylphenidate. By understanding these interactions, healthcare providers can guide patients to make informed decisions about their alcohol consumption, ensuring a smoother and more effective treatment journey.

Dr. Camel's Conclusion

This study underscores the importance of considering potential drug interactions when treating patients with ADHD. The finding that ethanol can significantly alter the pharmacokinetics of methylphenidate provides a valuable warning sign in the desert of ADHD treatment, emphasizing the need for careful monitoring and patient education to ensure optimal treatment outcomes.

Date :
  1. Date Completed 2018-04-03
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

28590363

DOI: Digital Object Identifier

NIHMS864349

Related Literature

Article Analysis
・Effects of dexmethylphenidate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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