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The effect of a week's beta-adrenoceptor antagonism on daytime heart-rates, subjective responses to exercise, and physical activity in normal subjects.

Author: BirminghamA T, PatrickJ M, WharradH J, WilsonC G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Beta-blockers significantly reduced heart rate during ambulatory monitoring. While subjects perceived exercise as harder, objective measures of physical activity showed no difference between treatments.
Paper Details　
Original Abstract of the Article :
The effects on heart rate (HR) and physical activity of 1 week's treatment with three different beta-adrenoceptor antagonists (20 mg betaxolol (Lorex); 160 mg propranolol LA; or 100 mg atenolol daily) have been compared with placebo in a double-blind study of 12 normal men. On the fifth day of each ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.1365-2125.1985.tb02629.x

データ提供：米国国立医学図書館（NLM）

Beta-Blockers and the Impact on Heart Rate and Physical Activity: A Double-Blind Study

Navigating the world of [cardiovascular medications] can be quite the journey. This research investigates the impact of three commonly prescribed [beta-blockers] on [heart rate], [subjective exercise perception], and [physical activity] in healthy individuals. The study used a [double-blind design] to compare the effects of these medications to a [placebo] in a group of 12 men.

Beta-Blockers: A Double-Edged Sword

The study found that while the participants on [beta-blockers] perceived standard exercise as more challenging and experienced some mild side effects, their [ambulatory heart rates] were significantly lower compared to the placebo group. This suggests that [beta-blockers] can effectively reduce heart rate, but may also impact perceived exertion during physical activity.

Dr.Camel's Conclusion

This study highlights the potential benefits and drawbacks of [beta-blockers] for individuals with [cardiovascular conditions]. While they can effectively reduce heart rate, they may also influence exercise perception. This underscores the importance of carefully considering individual needs and potential side effects when choosing cardiovascular medications, a decision best made in consultation with a healthcare professional.

Date :
  1. Date Completed 1985-06-03
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2859043

DOI: Digital Object Identifier

10.1111/j.1365-2125.1985.tb02629.x

Related Literature

Article Analysis
・Side Effects of betaxolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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