Paper Details

  1. Home
  2. Paper Details

European Cooperative Crohn's Disease Study (ECCDS): clinical features and natural history.

Author: HoltermüllerK H, KasperH, LoeschkeK, SchäferH, SteinhardtH J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the natural course of Crohn's disease in 110 patients who received placebo. The study found that patients with ileocolonic Crohn's disease were younger than those with only colonic or small intestinal involvement. The most common location of Crohn's disease was the small and large intestines (49%). Patients with small intestinal involvement experienced milder symptoms compared to those with other locations. 60% of patients with active disease achieved a temporary remission within 5 months, and 23% of those with active disease and 68% of those with inactive disease remained in remission after 2 years. Factors associated with a better outcome in the placebo group included longer disease duration, normal albumin levels, and combined small and large intestinal involvement. However, extensive small bowel disease, previous steroid treatment, and previous surgery were associated with poorer outcomes. The study suggests that while some patients experience remission without treatment, Crohn's disease is a complex condition with varying factors influencing its course.
Paper Details　
Original Abstract of the Article :
In the European Cooperative Crohn's Disease Study patients from 14 centers were included in whom diagnosis was made within 2 years before study entry on the basis of generally accepted radiological, endoscopical and/or histological criteria or a combination of all. Reasons for exclusion were: diagno...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1159/000199186

データ提供：米国国立医学図書館（NLM）

Understanding Crohn's Disease: A Long and Winding Journey

Crohn's disease, a chronic inflammatory bowel disease, can be a challenging and unpredictable journey for those who suffer from it. This study, a collaborative effort from 14 European centers, aimed to investigate the clinical features and natural history of Crohn's disease in a large cohort of patients. The researchers gathered data on a wide range of clinical characteristics, including anatomical location, disease activity, and outcomes in patients with Crohn's disease.

Clinical Features and Natural History: A Diverse Landscape

The study revealed that Crohn's disease can manifest in different ways, with a variety of clinical features and disease courses. The researchers observed a significant variation in anatomical location, with patients experiencing involvement in the ileum, colon, or both. They also noted that disease activity could fluctuate over time, with some patients experiencing periods of remission and others experiencing ongoing symptoms. It's like navigating a diverse desert landscape, with different terrains and weather patterns.

Navigating the Path to Remission: Factors Influencing Outcome

The study identified several factors associated with a more favorable outcome in patients with Crohn's disease, including longer duration of disease, normal serum albumin levels, and combined involvement of the small intestine and colon. Conversely, factors associated with a less favorable outcome included extensive small bowel disease, treatment with steroids, and previous bowel resection. It's like finding a hidden oasis of remission in the desert of Crohn's disease, with certain factors paving the way towards a better outcome.

Dr. Camel's Conclusion

This study provides a comprehensive look at the diverse landscape of Crohn's disease, highlighting the importance of understanding the clinical features and natural history of this complex condition. It's like navigating a vast desert, where a thorough understanding of the terrain can lead to a more favorable outcome.

Date :
  1. Date Completed 1985-07-11
  2. Date Revised 2018-02-16
Further Info :

Pubmed ID

2860044

DOI: Digital Object Identifier

10.1159/000199186

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.