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Preclinical assessment of safety of maternal vaccination against respiratory syncytial virus (RSV) in cotton rats.

Author: BlancoJorge C G, BoukhvalovaMarina S, OtoaRaymonde O, PatelMira C, PletnevaLioubov M, VogelStefanie N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explores the safety of maternal vaccination against RSV using a model in cotton rats. The research investigates whether an unsafe RSV vaccine can induce vaccine-enhanced disease in the presence of maternal immunity. The findings suggest that while a known unsafe RSV vaccine does not pose a health risk to mothers or infants, "safe" RSV vaccines might induce vaccine-enhanced disease in infected pups born to seropositive mothers. The study also highlights a decline in RSV neutralizing antibody titers in immunized seropositive mothers around the time of delivery, potentially identifying a window of increased vulnerability to RSV infection.
Paper Details　
Original Abstract of the Article :
Maternal immunization directed to control RSV infection in newborns and infants is an appealing vaccination strategy currently under development. In this work we have modeled maternal vaccination against RSV in cotton rats (CR) to answer two fundamental questions on maternal vaccine safety. We teste...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28624306

データ提供：米国国立医学図書館（NLM）

Maternal Vaccination for RSV: A Safety Assessment in Cotton Rats

The quest for effective vaccines against respiratory syncytial virus (RSV) is a hot topic in immunology. This study investigated the safety of maternal RSV vaccination in cotton rats, using a known unsafe vaccine as a model. Researchers explored whether this vaccine could induce vaccine-enhanced disease in pups born to RSV-seropositive mothers. The findings suggest that while the tested vaccine did not pose a risk to mothers, it could potentially enhance disease in infants infected with RSV, especially those born to mothers with pre-existing immunity. This highlights the need for careful evaluation of maternal RSV vaccines to ensure their safety for both mothers and infants.

A New Concern for Infant Immunization

This study raises a critical question: could 'safe' RSV vaccines, like live RSV administered intramuscularly, also induce vaccine-enhanced disease in infants born to RSV-seropositive mothers? The researchers observed a decline in RSV neutralizing antibody titers in immunized mothers at delivery, suggesting a potential window of increased vulnerability to RSV infection for infants. This finding underscores the importance of careful monitoring and further research to ensure the safety of RSV vaccines for infants, especially those born to mothers with pre-existing RSV immunity.

The Importance of Pre-Clinical Research

This pre-clinical study in cotton rats is crucial for understanding the potential risks and benefits of maternal RSV vaccination. The findings highlight the importance of pre-clinical research in guiding the development of safe and effective vaccines for infants. The study reminds us that while a vaccine may be safe for mothers, it might not be equally safe for infants, especially in the context of maternal immunity. This emphasizes the importance of careful evaluation and testing to ensure the safety and effectiveness of new vaccines.

Dr. Camel's Conclusion

This research, like a caravan navigating a treacherous desert, provides valuable insights into the potential risks and benefits of maternal RSV vaccination. The researchers, like seasoned desert guides, have revealed a potential risk of vaccine-enhanced disease in infants born to seropositive mothers, urging us to proceed with caution and further research.

Date :
  1. Date Completed 2018-03-12
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

28624306

DOI: Digital Object Identifier

NIHMS883020

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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