Andexanet alfa: a recombinant mimetic of human factor Xa for the reversal of anticoagulant therapies.

Author: Arellano-RodrigoE, Diaz-RicartM, EscolarG

Paper Details 
Original Abstract of the Article :
Activated coagulation factor X (FXa) is a common target for classic and newer anticoagulants. Parenteral anticoagulants with an indirect inhibitory action on FXa (low-molecular-weight heparins) have a well-established clinical efficacy in the prophylaxis and therapy of thromboembolic conditions. Mor...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1358/dot.2017.53.5.2630780

データ提供:米国国立医学図書館(NLM)

Andexanet Alfa: Reversing Anticoagulant Therapies

The field of anticoagulation is a delicate dance, balancing the need to prevent blood clots with the risk of excessive bleeding. This study, like a skilled choreographer, introduces andexanet alfa, a new agent designed to reverse the effects of anticoagulants that target factor Xa. This research, like a desert caravan exploring a new route, delves into the preclinical pharmacology and clinical development of andexanet alfa, offering a potential solution for managing anticoagulant-related bleeding.

A New Tool for Managing Anticoagulation

Andexanet alfa, like a well-stocked oasis in the desert, offers a promising new option for managing anticoagulant-related bleeding. This research, like a map charting a new course, reveals the potential of andexanet alfa to safely and effectively reverse the anticoagulant effects of both direct and indirect factor Xa inhibitors, potentially improving patient outcomes and reducing the risks associated with anticoagulant therapy.

Navigating the Anticoagulation Landscape

The study emphasizes the importance of continued research and development in the field of anticoagulation, comparing this process to navigating a dynamic desert landscape. The authors encourage further exploration of andexanet alfa's potential, aiming to optimize its use and further enhance the management of anticoagulant-related bleeding.

Dr.Camel's Conclusion

This research, like a guiding star illuminating the desert night, offers a promising new approach to managing anticoagulation-related bleeding. Andexanet alfa, like a well-stocked oasis, holds the potential to improve patient outcomes and enhance the safety of anticoagulant therapies.

Date :
  1. Date Completed 2017-08-24
  2. Date Revised 2017-08-24
Further Info :

Pubmed ID

28650000

DOI: Digital Object Identifier

10.1358/dot.2017.53.5.2630780

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.