The Effects of Switching to Vonoprazan, a Novel Potassium-Competitive Acid Blocker, on Gastric Acidity and Reflux Patterns in Patients with Erosive Esophagitis Refractory to Proton Pump Inhibitors.

Author: EguchiTakaaki, FujitaMikio, HashimuraHiroki, KanamoriAtsushi, KanoChise, MatsumotoKei, MomoseKenji, ObataDaisuke, OkadaAkihiko, TsujimaeMasahiro, YamashitaHiroshi, YoshizakiTetsuya

Paper Details 
Original Abstract of the Article :
BACKGROUND/AIM: The effects of vonoprazan and proton pump inhibitors (PPIs) in patients with reflux esophagitis (RE) have not yet been compared using multichannel intraluminal impedance-pH (MII-pH). METHODS: A total of 8 patients with persistent gastric mucosal injury, despite completing an 8-week ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1159/000478255

データ提供:米国国立医学図書館(NLM)

Vonoprazan: A New Hope for Reflux Esophagitis

[Reflux esophagitis] can be a real pain, literally! This study explores the effectiveness of [vonoprazan], a new drug, in treating patients who haven't responded well to traditional medications like [proton pump inhibitors (PPIs)]. The researchers used [multichannel intraluminal impedance-pH (MII-pH)] to measure the effects of vonoprazan on gastric acidity and reflux patterns. The results suggest that vonoprazan could be a promising treatment option for those struggling with [PPI-refractory reflux esophagitis].

Vonoprazan: A Potential Solution for Resistant Reflux

Vonoprazan, like a skilled desert traveler equipped with a water-finding stick, can effectively manage gastric acidity and reflux. The study found that vonoprazan significantly increased gastric pH and reduced acid reflux events in patients with [PPI-refractory reflux esophagitis]. This offers a beacon of hope for patients who haven't found relief with traditional treatments.

Vonoprazan: A New Era in Reflux Treatment

This study, like a refreshing oasis in the desert of reflux treatment, suggests that vonoprazan could be a valuable tool in managing this condition. It's a promising development for patients seeking effective and durable relief from their symptoms.

Dr.Camel's Conclusion

This research is like a desert expedition, revealing the potential of vonoprazan as a new and effective treatment for [PPI-refractory reflux esophagitis]. The findings offer hope for patients who haven't found relief with traditional medications and highlight the importance of ongoing research in developing new therapeutic strategies.

Date :
  1. Date Completed 2018-04-30
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

28662503

DOI: Digital Object Identifier

10.1159/000478255

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.