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A single center, open label study of intradermal administration of an inactivated purified chick embryo cell culture rabies virus vaccine in adults.
Author: OsinubiModupe O V, RecuencoSergio, RupprechtCharles E, WarnockEli
Original Abstract of the Article :
In the USA, rabies vaccines (RVs) are licensed for intramuscular (IM) use only, although RVs are licensed for use by the intradermal (ID) route in many other countries. Recent limitations in supplies of RV in the USA reopened discussions on the more efficient use of available biologics, including ut...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.vaccine.2017.06.083
データ提供:米国国立医学図書館(NLM)
Intradermal Administration of an Inactivated Purified Chick Embryo Cell Culture Rabies Virus Vaccine
The desert of rabies prevention is a landscape where every precaution counts. This study investigates the safety and immunogenicity of an inactivated purified chick embryo cell (PCEC) rabies virus vaccine administered via the intradermal (ID) route in adults.
The researchers conducted an open-label study comparing the immunogenicity and adverse effects of ID and intramuscular (IM) vaccination. They evaluated antibody titers and monitored for adverse events in 130 adult volunteers.
The study demonstrated that ID administration of the PCEC rabies vaccine was safe and immunogenic, with comparable antibody responses to IM vaccination. The ID route allowed for a more efficient use of vaccine, offering potential advantages in terms of resource utilization and minimizing waste.
A New Avenue for Rabies Vaccination
This research offers a promising alternative approach to rabies vaccination, with the potential to improve vaccine efficiency and resource utilization. The findings suggest that ID administration could be a viable and effective option for rabies pre-exposure prophylaxis and booster vaccinations.
Navigating the Desert of Rabies Prevention
This research highlights the importance of continuous innovation and exploration in the field of rabies prevention. Finding more efficient and effective vaccination strategies is crucial for protecting individuals and communities from this potentially fatal disease. It's a reminder that even in the face of challenging conditions, we can find new solutions and continue to make progress in the fight against disease.
Dr.Camel's Conclusion
This study shows that the desert of rabies prevention is full of potential for new discoveries and advancements. By exploring different routes of administration and optimizing vaccine delivery, we can strengthen our defenses against this deadly virus and protect more people from its devastating effects.
Date :
- Date Completed 2018-03-19
- Date Revised 2018-04-02
Further Info :
Related Literature
English
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