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The immunomodulatory effects of the Enalapril in combination with Benznidazole during acute and chronic phases of the experimental infection with Trypanosoma cruzi.
Author: LeiteAna Luisa Junqueira, LopesLaís Roquete, Paula CostaGuilherme de, Reis MotaLudmilla Walter Dos, TalvaniAndré, VieiraPaula Melo de Abreu
Original Abstract of the Article :
Trypanosoma cruzi infection triggers a chronic inflammatory process responsible for the alterations in the extracellular matrix and functionality of the heart. The angiotensin converting enzyme (ACE) inhibitors affects T. cruzi in vitro surveillance and modulates in vivo some inflammatory mediators....See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.actatropica.2017.07.005
データ提供:米国国立医学図書館(NLM)
Enalapril and Benznidazole: A Combined Approach to Combat Chagas Disease
Chagas disease, caused by the parasite *Trypanosoma cruzi*, is a debilitating illness affecting millions worldwide. This study investigates the combined therapeutic effects of enalapril, an angiotensin-converting enzyme (ACE) inhibitor, and benznidazole, a standard treatment for Chagas disease, in mice infected with *Trypanosoma cruzi*. Imagine a camel facing a challenging desert storm, seeking protection and relief. Researchers in this study explored the potential of a combined therapy to fight the effects of this parasitic infection. They discovered that the combination of enalapril and benznidazole significantly reduced inflammatory markers and controlled parasite replication in both the acute and chronic phases of infection. This finding suggests that this combined therapy could be a promising approach to combating Chagas disease, offering a more effective treatment strategy.
Fighting Chagas: A Combined Force in the Desert
This study sheds light on the potential of a combined therapy using enalapril and benznidazole in treating Chagas disease. The researchers found that this combination effectively reduced inflammation and controlled parasite replication, demonstrating its promising potential for combatting this debilitating disease. This research, like a camel finding a hidden oasis in the midst of a desert storm, offers a new avenue for treating Chagas disease.
A Camel's Perspective on Chagas Disease: A Combined Approach
This research underscores the importance of exploring innovative approaches to treating complex diseases like Chagas. The combined therapy using enalapril and benznidazole offers a promising approach to combating this disease, potentially leading to improved treatment outcomes. It's important to remember that Chagas disease can have long-term effects, making early detection and effective treatment crucial. Just as a camel relies on its resilience to survive in the desert, understanding and addressing Chagas disease requires a comprehensive approach, combining medical expertise with preventive measures.
Dr. Camel's Conclusion
The combined therapy using enalapril and benznidazole shows promise in combating Chagas disease, offering a potential solution to this challenging parasitic infection. This research, like a camel finding a hidden oasis in the desert, highlights the importance of innovative approaches and multi-faceted treatments in battling complex diseases.
Date :
- Date Completed 2018-02-12
- Date Revised 2018-12-02
Further Info :
Related Literature
English
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