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Optimization and <i>In Vivo</i> Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods.

Author: KuoAndy, ShenoyPriyank, SmithMaree T, VetterIrina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study established a clinically relevant rat model of breast cancer-induced bone pain. The model showed that hindpaw hypersensitivity resolved after approximately 25 days, in the continued presence of bone tumors. The authors suggest that this model can be used to test the efficacy of novel analgesic agents for the relief of pain due to bony metastases.
Paper Details　
Original Abstract of the Article :
In the majority of patients with advanced breast cancer, there is metastatic spread to bones resulting in pain. Clinically available drug treatments for alleviation of breast cancer-induced bone pain (BCIBP) often produce inadequate pain relief due to dose-limiting side-effects. A major impediment t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498471/

データ提供：米国国立医学図書館（NLM）

Breast Cancer-Induced Bone Pain: A Refined Rat Model for Pain Research

Breast cancer, when it spreads to bones, can cause excruciating pain, turning the bones into a desert of discomfort. This study focuses on developing a refined rat model to study breast cancer-induced bone pain (BCIBP). The researchers meticulously characterized the model using behavioral assessments, radiology, histology, immunohistochemistry, and pharmacological methods. They established a model that closely mimics the human condition, making it a valuable tool for studying BCIBP and testing new analgesics.

A Refined Rat Model: A New Oasis in the Desert of Pain Research

Imagine a desert where even the smallest grain of sand can cause unbearable pain. This study explores a refined rat model that allows researchers to study BCIBP in a more realistic and controlled environment. This model is a potential oasis in the desert of pain research, providing researchers with a powerful tool to develop more effective treatments for BCIBP.

Understanding Bone Pain: A Critical Step in Pain Management

BCIBP can be a devastating complication of breast cancer. This study highlights the importance of developing animal models that accurately reflect the human condition. By understanding the mechanisms underlying BCIBP, researchers can develop more effective treatments to alleviate this debilitating pain.

Dr. Camel's Conclusion

This study introduces a refined rat model that offers a more realistic and clinically relevant platform for studying breast cancer-induced bone pain. This model is crucial for advancing our understanding of BCIBP and for developing new analgesics that can effectively alleviate this type of pain.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

28729837

DOI: Digital Object Identifier

PMC5498471

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