Paper Details

  1. Home
  2. Paper Details

Antipsychotic drugs for the acute treatment of patients with a first episode of schizophrenia: a systematic review with pairwise and network meta-analyses.

Author: ChaimaniAnna, DavisJohn M, HuhnMaximilian, KrauseMarc, LeuchtStefan, LiChunbo, RothePhilipp, Schneider-ThomaJohannes, ZhuYikang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Haloperidol seems to be a suboptimal treatment option for acute treatment of first-episode schizophrenia, but we found little difference between second-generation antipsychotics. The evidence was generally of low quality and the numbers of patients for each drug were small.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The first episode of schizophrenia is a pivotal phase of this debilitating illness. Which drug to use remains controversial without a summary of all direct or indirect comparisons of drugs. We did a systematic review with pairwise and network meta-analyses of efficacy and tolerability. ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/S2215-0366(17)30270-5

データ提供：米国国立医学図書館（NLM）

Antipsychotic Drugs for the Acute Treatment of First-Episode Schizophrenia

This study ventures into the challenging landscape of schizophrenia treatment, focusing on the crucial period of a first episode. Imagine this as a camel caravan navigating a vast and unpredictable desert, seeking the most effective path to alleviate the debilitating symptoms of schizophrenia. The researchers conducted a comprehensive systematic review and network meta-analysis, comparing the efficacy and tolerability of various antipsychotic drugs in treating first-episode schizophrenia.

Finding the Right Path in a Complex Desert

The study found that certain second-generation antipsychotics, such as amisulpride, olanzapine, ziprasidone, and risperidone, were more effective than haloperidol in reducing overall symptoms. This is like discovering a path through the desert that leads to a more favorable outcome. However, the study also highlights the need for careful consideration of side effects, as each medication has a unique profile. This is similar to how a camel caravan must choose its route based on the specific challenges and risks of each terrain.

Navigating the Shifting Sands of Treatment Options

The study emphasizes that the choice of treatment should be tailored to the individual patient, considering their specific symptoms and potential side effects. This is like how a camel caravan adapts its strategy based on the changing landscape of the desert. Further research is needed to refine treatment strategies and optimize outcomes for those living with schizophrenia, ensuring that the journey towards recovery is as smooth and successful as possible.

Dr.Camel's Conclusion

This research highlights the complexities of treating schizophrenia, a challenging condition that demands careful consideration of individual needs and potential side effects. Like a camel caravan traversing a vast and unforgiving desert, we must navigate this complex landscape with knowledge, compassion, and a commitment to finding the best possible solutions for those affected.

Date :
  1. Date Completed 2019-07-01
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

28736102

DOI: Digital Object Identifier

10.1016/S2215-0366(17)30270-5

Related Literature

Article Analysis
・Side Effects of molindone・Effects of molindone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.