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Use and safety of antiepileptic drugs in psychiatric inpatients-data from the AMSP study.

Author: BleichStefan, DruschkyKatrin, EngelRolf R, GreilWaldemar, GrohmannRenate, KleimannAlexandra, StübnerSusanne, TotoSermin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the use of antiepileptic drugs (AEDs) in psychiatry. Valproic acid was the most commonly used AED, followed by lamotrigine and pregabalin. Valproic acid was associated with fewer severe adverse drug reactions compared to other AEDs. The findings highlight the importance of careful monitoring and managing potential side effects during AED use in psychiatric patients.
Paper Details　
Original Abstract of the Article :
The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoa...See full text at original site
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引用元：
https://doi.org/10.1007/s00406-017-0827-5

データ提供：米国国立医学図書館（NLM）

Navigating the Landscape of Antiepileptic Drugs in Psychiatric Patients

The use of [antiepileptic drugs (AEDs)] extends beyond their traditional role in [epilepsy management] and often involves [off-label] applications in [psychiatric] settings. This research examines the [utilization patterns and safety] of [AEDs] in [psychiatric inpatients] over a 20-year period, providing insights into their clinical use and potential risks.

Valproic Acid: A Dominant Player in Psychiatric Practice

The study reveals that [valproic acid (VPA)] emerged as the most commonly administered [AED] among [psychiatric inpatients], while the use of other [AEDs] like [carbamazepine (CBZ)] declined over time. The rise of [valproic acid (VPA)] is likely due to its efficacy in treating [acute mania and other psychiatric conditions], along with its [favorable adverse event profile] compared to other [AEDs] like [oxcarbazepine (OXC)].

Understanding AED Risks and Benefits

This research underscores the importance of carefully considering the [risk-benefit profile] of [AEDs] in [psychiatric patients]. While they can offer valuable therapeutic benefits, it is crucial to be aware of potential [adverse drug reactions (ADRs)] such as [hyponatremia, allergic skin reactions, and oedema], and to monitor patients closely for any signs of [toxicity].

Dr.Camel's Conclusion

Just as a camel navigates the desert, finding safe routes through treacherous terrain, clinicians must navigate the complex landscape of [AEDs] in [psychiatric patients]. This research serves as a valuable guide, highlighting the need for careful consideration of [drug choice, dosage, and potential side effects] in this population. By understanding the nuances of [AED] use, clinicians can ensure optimal treatment outcomes and minimize the risk of [adverse events].

Date :
  1. Date Completed 2018-09-11
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28766129

DOI: Digital Object Identifier

10.1007/s00406-017-0827-5

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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