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Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia.

Author: CuiJia-Hua, JiangWan-Wei, LiYu, LiaoYa-Jing, WangQing-Hui, XuMin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oxycodone and morphine both suppress immune function in patients undergoing rectal cancer surgery, but oxycodone has a smaller effect. In this study, 80 patients were randomly divided into two groups, both receiving general intravenous anesthesia. Group A received oxycodone (5mg) and Group B received morphine (5mg) at the end of surgery. The results showed that both drugs decreased the number of T lymphocytes and NK cells, but oxycodone had a less significant effect.
Paper Details　
Original Abstract of the Article :
This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia.Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent general...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626124/

データ提供：米国国立医学図書館（NLM）

Oxycodone's Impact on Immune Function After Rectal Cancer Surgery

Surgical interventions are often accompanied by pain management strategies, and opioids are frequently used to alleviate postoperative discomfort. This study investigates the effects of oxycodone hydrochloride on immune function in patients undergoing radical resection of rectal cancer under general anesthesia.

The study involved 80 patients randomly assigned to receive either oxycodone hydrochloride (Group A) or morphine hydrochloride (Group B) after surgery. The researchers monitored changes in the numbers of T lymphocyte subsets and natural killer (NK) cells using flow cytometry at different time points following surgery.

Oxycodone's Potential to Mitigate Immune Suppression

The results showed that both oxycodone hydrochloride and morphine hydrochloride had inhibitory effects on immune function after surgery. However, oxycodone hydrochloride had a significantly smaller effect on T lymphocyte and NK cell numbers compared to morphine hydrochloride.

Balancing Pain Management and Immune Health

This study provides valuable insights into the potential impact of opioid analgesics on immune function in patients undergoing surgery. The findings suggest that oxycodone hydrochloride might be a more immune-sparing option compared to morphine hydrochloride. Further research is needed to optimize pain management strategies while minimizing the potential for immune suppression.

Dr.Camel's Conclusion

The desert of postoperative pain management is often traversed with the aid of opioids, but their impact on immune function can be a hidden sandstorm. This study highlights the potential of oxycodone hydrochloride to navigate this terrain with less immune suppression than morphine hydrochloride. As we continue our quest for better pain management strategies, understanding the nuances of opioid effects on the immune system is crucial for ensuring optimal patient outcomes.

Date :
  1. Date Completed 2017-08-22
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

28767570

DOI: Digital Object Identifier

PMC5626124

Related Literature

Article Analysis
・Effects of morphine rectal
SNS
PICO Info
in preparation
Languages

English

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