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Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis.

Author: BarlinnKristian, MaierSarah, RiedigerCarina, SchusterTibor, SiepmannTimo, WeitzJürgen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Antidepressants are often used to treat chronic pain at lower doses than those required for their antidepressant effects. While these drugs have been shown to be effective in large randomized-controlled trials (RCTs), there is inconsistent evidence about their adverse effects and tolerability.
Paper Details　
Original Abstract of the Article :
Antidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect. While efficacy of antidepressants for chronic pain has been reported in large randomized-controlled trials (RCT), there is inconsistent data on adverse effe...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510574/

データ提供：米国国立医学図書館（NLM）

Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-Analysis

Chronic pain is a complex and often debilitating condition. This study explores the use of antidepressants in the treatment of chronic pain, focusing on their potential side effects. The authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the adverse effect profiles of antidepressants for chronic pain. The study aims to provide a comprehensive overview of the potential risks associated with using antidepressants for this indication.

Balancing Benefits and Risks

The study found that antidepressants are often effective in reducing chronic pain, but they can also have a range of adverse effects. The authors emphasize the importance of balancing the potential benefits of antidepressants with their potential risks. They recommend careful consideration of individual patient factors, including pre-existing conditions and potential drug interactions, before prescribing antidepressants for chronic pain. It's like navigating a desert, where the potential for reward must be weighed against the risks involved.

Informed Decision-Making

This research highlights the importance of informed decision-making when considering antidepressants for chronic pain. It emphasizes the need for careful consideration of the potential benefits and risks, as well as individual patient factors. Patients should be fully informed about the potential side effects and actively participate in the decision-making process to ensure they are making the best choice for their health and well-being.

Dr.Camel's Conclusion

This study sheds light on the potential adverse effects of antidepressants for chronic pain, underscoring the importance of balancing benefits with risks. It reinforces the need for informed decision-making and emphasizes the importance of considering individual patient factors before prescribing antidepressants for this indication. Just as a desert traveler must be aware of the potential dangers of the journey, so too must healthcare professionals and patients carefully weigh the potential benefits and risks of medications.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

28769859

DOI: Digital Object Identifier

PMC5510574

SNS
PICO Info
in preparation
Languages

English

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