Side Effects of desipramine: A Synthesis of Findings from 24 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of desipramine: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Findings

Desipramine is a tricyclic antidepressant that is often used to treat depression and other mental health conditions. It works by blocking the reuptake of certain neurotransmitters in the brain, which helps to improve mood and reduce symptoms of depression. 23

However, like all medications, desipramine can cause side effects. 3 1 15 10 6 Some side effects are common and mild, while others are more serious and may require medical attention. 1

Reasons for Side Effects

Desipramine can cause side effects because it affects different organs and tissues in the body. For example, desipramine can affect the heart, increasing heart rate and blood pressure. It can also affect the digestive system, causing constipation, nausea, or loss of appetite. Additionally, desipramine can affect the central nervous system, causing drowsiness, dizziness, decreased concentration, hallucinations, or worsening anxiety and tension. 21 13 5

Common Side Effects

Drowsiness

Desipramine can cause drowsiness and fatigue. 1 13 5 This side effect is often seen soon after starting the medication. 1 Avoid activities that require concentration, such as driving or operating machinery, while taking desipramine. 1

Dry Mouth

Desipramine can cause dry mouth. 1 5 This is because the drug suppresses saliva production. 1 If you experience dry mouth, drink plenty of fluids. 1

Constipation

Desipramine can cause constipation. 1 This is because the drug slows down bowel movements. 1 If you are concerned about constipation, eat foods high in fiber, drink plenty of fluids, and exercise. 1

Weight Gain

Desipramine can cause weight gain. 1 5 This is because the drug can increase appetite and decrease metabolism. 1 If you are concerned about weight gain, consider diet and exercise. 1

Sexual Dysfunction

Desipramine can cause sexual dysfunction. 17 5 This is because the drug can suppress sex hormone production or inhibit neurotransmitter function. 17 If you are concerned about sexual dysfunction, talk to your doctor. 17

Others

Desipramine can cause a variety of other side effects besides those listed above. 3 1 15 13 5 6 If you are concerned about side effects, talk to your doctor. 3

Countermeasures for Side Effects

Drowsiness

Drowsiness is often seen soon after starting desipramine. 1 13 5 If you are concerned about drowsiness, talk to your doctor and adjust the time of administration or reduce the dosage. 1 Also, avoid activities that require concentration, such as driving or operating machinery, while taking desipramine. 1

Dry Mouth

Dry mouth is because desipramine suppresses saliva production. 1 If you experience dry mouth, drink plenty of fluids. 1

Constipation

Constipation is because desipramine slows down bowel movements. 1 If you are concerned about constipation, eat foods high in fiber, drink plenty of fluids, and exercise. 1 If it doesn't improve, consult your doctor. 1

Weight Gain

Weight gain is because desipramine can increase appetite and decrease metabolism. 1 If you are concerned about weight gain, consider diet and exercise. 1 If it doesn't improve, consult your doctor. 1

Sexual Dysfunction

Sexual dysfunction is because desipramine can suppress sex hormone production or inhibit neurotransmitter function. 17 If you are concerned about sexual dysfunction, talk to your doctor. 17 Your doctor may adjust your dose of desipramine, prescribe other medications, or recommend counseling. 17

Comparison of Studies

Commonalities

Multiple studies have shown that desipramine can cause a variety of side effects. 3 1 15 10 6

Differences

The frequency and severity of desipramine side effects vary from person to person. 3 1 In addition, desipramine side effects may vary depending on age, gender, and dosage. 1

Precautions for Real-Life Application

Desipramine is an effective medication for the treatment of mental illnesses such as depression, but it can cause a variety of side effects. 3 1 15 10 6 When taking desipramine, always follow your doctor's instructions and consult your doctor immediately if you experience any side effects. 3

Limitations of Current Research

Research on desipramine side effects is still inadequate. 3 1 15 10 6 In particular, the side effects of desipramine when taken long-term are not yet fully understood. 23

Future Research Directions

Research on desipramine side effects needs to be further investigated. 3 1 15 10 6 In particular, research is needed on the side effects of desipramine when taken long-term, individual differences in desipramine side effects, and ways to reduce desipramine side effects. 23 14

Conclusion

Desipramine is an effective medication for the treatment of mental illnesses such as depression, but it can cause a variety of side effects. 3 1 15 10 6 When taking desipramine, always follow your doctor's instructions and consult your doctor immediately if you experience any side effects. 3

Literature analysis of 24 papers
Positive Content
20
Neutral Content
1
Negative Content
3
Article Type
1
4
3
5
24
1.

Side effects of desipramine and age.

Author: GalanterCathryn A, BilichCarina, WalshB Timothy

Changes in vital signs
Constipation
Dry mouth

Desipramine treatment produces different subjective side effects and changes in vital signs across age groups. Younger patients (18 and younger) have lower ratings for constipation and dry mouth, and experience different changes in pulse and blood pressure compared to older patients (19 and older).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Side effects of desipramine and age.

Author: GalanterCathryn A, BilichCarina, WalshB Timothy

Changes in vital signs
Constipation
Dry mouth

Desipramine treatment produces different subjective side effects and changes in vital signs across age groups. Younger patients (18 and younger) have lower ratings for constipation and dry mouth, and experience different changes in pulse and blood pressure compared to older patients (19 and older).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Side effects of methylphenidate and desipramine alone and in combination in children.

Author: PatakiC S, CarlsonG A, KellyK L, RapportM D, BiancanielloT M

Heart rate increase
PR interval prolongation
Side effects

Combined methylphenidate and desipramine treatment resulted in more frequent side effects compared to either drug alone. These side effects were similar to those associated with desipramine alone and were not more serious.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain.

Author: SerafiniRandal A, EstillMolly, PekarskayaElizabeth A, SaklothFarhana, ShenLi, JavitchJonathan A, ZachariouVenetia

Faster pain relief
Reduced side effects

Tianeptine, an atypical antidepressant, was found to be more effective than desipramine in alleviating neuropathic pain in mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

An in-depth analysis of four classes of antidepressants quantification from human serum using LC-MS/MS.

Author: FarihaRamisa, DeshpandePrutha S, RothkopfEmma, JabrahMohannad, SpoonerAdam, OkohOluwanifemi David, TripathiAnubhav

Accurate antidepressant monitoring
Automated sample preparation

An automated liquid chromatography tandem mass spectrometry (LC-MS/MS) assay was developed to monitor the levels of different classes of antidepressants in women. The assay is accurate and automatable, using only 20 μL of a serum sample. It has the potential to be translated to clinical settings to monitor postpartum depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Dose effects of tricyclic antidepressants in the treatment of acute depression - A systematic review and meta-analysis of randomized trials.

Author: BaethgeChristopher, BraunCora, RinkLena, SchwarzerGuido, HensslerJonathan, BschorTom

Antidepressant efficacy
Adverse events

A systematic review of 15 randomized trials on tricyclic antidepressants (TCAs) found inconclusive evidence of a dose-response relationship. While some comparisons showed no clear signal of a dose gradient, 300 mg of imipramine/desipramine was statistically significantly superior to 150 mg.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation.

Author: ZahirMaziar, ShariatzadehSiavash, KhosraviAyda, AlshaikhFatima Ahmed, MoradiParichehr, GhaderiMilad, FarsinejadParsa, LouyehParisa Afraz, IlkhaniSaba, NakhaeiPooria, TaheriAmin, FaghehAvid Farhang, Akhavan-SigariReza

Liver dysfunction

This study investigated the effect of social isolation stress (SIS) on liver function and drug toxicity. SIS may contribute to liver dysfunction through inflammation and oxidative stress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Pharmacological interventions for antisocial personality disorder.

Author: KhalifaNajat R, GibbonSimon, VöllmBirgit A, CheungNatalie H-Y, McCarthyLucy

Improved antisocial personality disorder

There is insufficient evidence to draw conclusions about the use of pharmacological interventions in the treatment of antisocial personality disorder (AsPD). Future studies should recruit participants on the basis of having AsPD and use relevant outcome measures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

A PHASE IIA STUDY REPOSITIONING DESIPRAMINE IN SMALL CELL LUNG CANCER AND OTHER HIGH-GRADE NEUROENDOCRINE TUMORS.

Author: RiessJonathan W, JahchanNadine S, DasMillie, Zach KoontzM, KunzPamela L, WakeleeHeather A, SchatzbergAlan, SageJulien, NealJoel W

Antitumor effects
Neuroendocrine carcinoma treatment

A bioinformatics analysis identified tricyclic antidepressants (TCAs) as potential antitumor agents in small cell lung cancer (SCLC) and other neuroendocrine cancers. This study aims to reposition desipramine, a TCA, for a clinical trial in SCLC and G3NEC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Modulation of Proton-Gated Channels by Antidepressants.

Author: NikolaevMaxim V, KomarovaMargarita S, TikhonovaTatiana B, KorostelevaAnastasia S, PotapjevaNatalia N, TikhonovDenis B

Antidepressant action

Some antidepressants were found to modulate the activity of acid-sensing ion channels (ASICs), which are expressed in brain neurons and participate in numerous CNS functions. Amitriptyline, chlorpromazine, desipramine, fluoxetine, and atomoxetine potentiated ASIC2a response, while tianeptine caused strong inhibition of ASIC2a.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Modulating cancer cell survival by targeting intracellular cholesterol transport.

Author: KuzuOmer F, GowdaRaghavendra, NooryMohammad A, RobertsonGavin P

Chemotherapeutic activity

This study explores the potential chemotherapeutic activity of functional acid sphingomyelinase inhibitors (FIASMAs) by disrupting cancer cell cholesterol homoeostasis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

A Comparison of Sexual Side Effects of Antidepressants With and Without Naltrexone.

Author: ThapaMona, PetrakisIsmene, RalevskiElizabeth

Sexual side effects

This randomized clinical trial compared the rate of sexual side effects of the selective serotonin reuptake inhibitor paroxetine versus the tricyclic antidepressant desipramine. The study also examined the effect of co-prescription of naltrexone on sexual side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Postherpetic neuralgia: epidemiology, pathophysiology, and pain management pharmacology.

Author: Mallick-SearleTheresa, SnodgrassBrett, BrantJeannine M

Herpes zoster prevention
Pain relief
Side effects

This article reviews herpes zoster (shingles) and postherpetic neuralgia (PHN), a debilitating neuropathic pain that can occur after shingles. It emphasizes the importance of vaccination and antiviral treatment for preventing shingles and discusses the management of PHN, including first-line medications like gabapentin, pregabalin, and tricyclic antidepressants.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.

Author: BittoloTamara, RaminelliCarlo Antonio, DeianaChiara, BajGabriele, VaghiValentina, FerrazzoSara, BernareggiAnnalisa, TongiorgiEnrico

Improved brain function
Improved breathing rate
Improved heart rate
Reduced anxiety

Mirtazapine, an antidepressant, was found to be more effective than desipramine in treating Rett syndrome in MeCP2-null mice, improving brain morphology, behavior, and cardio-respiratory function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Alternative pharmacological strategies for adult ADHD treatment: a systematic review.

Author: BuoliMassimiliano, SeratiMarta, CahnWiepke

ADHD treatment
Amphetamine side effects

Adult ADHD is a common condition that can be disabling. While standard medications are helpful, they don't always work long-term, and some people don't respond well. This review examines alternative medications for ADHD. Amphetamines have shown the most effectiveness but can have serious side effects. Certain antidepressants may also be effective but should be avoided in people with bipolar disorder. Finally, metadoxine and lithium might be better options for those with alcohol misuse or bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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