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Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS.

Author: Aubry-RozierBérengere, Cohen-SolalMartine, EastellRichard, EriksenErik Fink, GuañabensNuria, LangdahlBente, Obermayer-PietschBarbara, RalstonStuart H, TsourdiElena, ZillikensM Carola

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

How long to treat osteoporosis is still being debated. While bisphosphonates stay in the bone for a long time, denosumab doesn't. Stopping denosumab may increase the risk of multiple fractures in the spine.
Paper Details　
Original Abstract of the Article :
The optimal duration of osteoporosis treatment is controversial. As opposed to bisphosphonates, denosumab does not incorporate into bone matrix and bone turnover is not suppressed after its cessation. Recent reports imply that denosumab discontinuation may lead to an increased risk of multiple verte...See full text at original site
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引用元：
https://doi.org/10.1016/j.bone.2017.08.003

データ提供：米国国立医学図書館（NLM）

Denosumab Discontinuation and Osteoporosis: A Call for Caution

Osteoporosis treatment is a complex endeavor, and the optimal duration of therapy remains a topic of debate. This research explores the implications of discontinuing denosumab, a medication commonly used to manage osteoporosis. Unlike bisphosphonates, denosumab does not integrate into bone matrix, and its cessation does not suppress bone turnover. However, recent reports suggest a potential increased risk of vertebral fractures following denosumab discontinuation. This raises concerns about the long-term implications of this treatment strategy.

Navigating the Risks and Benefits of Denosumab: A Complex Balancing Act

The research highlights the need for careful consideration of the potential risks and benefits associated with denosumab discontinuation. The increased risk of vertebral fractures underscores the importance of ongoing monitoring and individualized treatment strategies. This study emphasizes the need for continued research to better understand the long-term effects of denosumab and to develop optimal treatment strategies for osteoporosis.

Osteoporosis and Denosumab: A Reminder of the Importance of Consultation

This research highlights the complexity of osteoporosis treatment and the importance of individualized care plans. If you are considering denosumab for osteoporosis, it's crucial to discuss your individual circumstances with your healthcare provider. They can assess your risk factors and help you make informed decisions about your treatment plan.

Dr.Camel's Conclusion

Denosumab is an effective treatment for osteoporosis, but its long-term effects are still being investigated. This research highlights the potential risk of vertebral fractures following denosumab discontinuation, underscoring the importance of ongoing monitoring and individualized care plans for osteoporosis patients.

Date :
  1. Date Completed 2018-06-11
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

28789921

DOI: Digital Object Identifier

10.1016/j.bone.2017.08.003

Related Literature

Article Analysis
・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

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