Pilot of a randomised controlled trial of the selective serotonin reuptake inhibitor sertraline versus cognitive behavioural therapy for anxiety symptoms in people with generalised anxiety disorder who have failed to respond to low-intensity psychological treatments as defined by the National Institute for Health and Care Excellence guidelines.

Author: BuszewiczMarta, CapeJohn, ClarkeCaroline S, KabirThomas, NazarethIrwin, SerfatyMarc, ShafranRoz, TyrerPeter

Overview

This abstract highlights the need for head-to-head comparisons of high-intensity cognitive behavioral therapy (CBT) and pharmacological treatment with sertraline for patients with generalized anxiety disorder (GAD) who do not respond to low-intensity interventions. The abstract points out the lack of definitive evidence to guide treatment choice at step 3 of the National Institute for Health and Care Excellence (NICE) guidelines.

Paper Details　

Original Abstract of the Article :

Generalised anxiety disorder (GAD) is common, causing unpleasant symptoms and impaired functioning. The National Institute for Health and Care Excellence (NICE) guidelines have established good evidence for low-intensity psychological interventions, but a significant number of patients will not resp...See full text at original site

Dr.Camel's Paper Summary Blog

Generalised Anxiety Disorder: Comparing Sertraline and CBT for Treatment-Resistant Patients

In the field of [Psychiatry], managing generalised anxiety disorder (GAD) presents a significant challenge, particularly in cases where patients do not respond to low-intensity psychological interventions. This study proposes a pilot randomized controlled trial to compare the effectiveness of sertraline, a selective serotonin reuptake inhibitor (SSRI), to cognitive behavioural therapy (CBT) in individuals with GAD who have failed to respond to low-intensity treatments. The authors aim to determine which treatment approach is more clinically effective and cost-effective, providing valuable insights into the management of treatment-resistant GAD.

The Quest for Effective Treatment: Comparing Sertraline and CBT for Treatment-Resistant GAD

This study delves into the complex world of GAD treatment, exploring the effectiveness of both pharmacological and psychological interventions for patients who have not responded to traditional approaches. The authors propose a pilot trial to compare the efficacy of sertraline to CBT, seeking to identify the most suitable treatment option for this challenging patient population. The study highlights the importance of considering individual patient needs and preferences when selecting treatment strategies, aiming to provide the most effective and cost-effective care.

Navigating Treatment-Resistant GAD: A Call for Personalized Approaches

This study underscores the need for personalized approaches in managing GAD, particularly for patients who have not responded to initial treatments. The authors recognize the importance of considering individual patient characteristics and preferences when selecting between pharmacological and psychological interventions, emphasizing the need for a tailored treatment plan that addresses the unique needs of each patient. The study also highlights the importance of continued research to develop more effective and accessible treatment options for GAD.

Dr.Camel's Conclusion

This study delves into the intricate world of GAD treatment, seeking to identify the most effective and cost-effective approach for patients who have not responded to traditional therapies. It's like exploring a desert, where finding the right path for each traveler is essential for achieving success. The study emphasizes the need for personalized approaches and continued research to develop more effective and accessible treatment options for GAD.