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Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate.

Author: BoussageonRémy, DuprezRenan, HuneauAlexandre, LaviolleBruno, LocherClara, NaudetFlorian, PalpacuerClément

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

There is currently no high-quality evidence to support the use of any pharmacological treatment to control drinking in patients with alcohol dependence or alcohol use disorder. Some treatments showed low to medium efficacy in reducing drinking, but none demonstrated any benefit on health outcomes.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND AIMS: Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders (AUDs) is an emerging concept. Our objective was to explore the comparative effectiveness of drugs used in this indication. DESIGN: Systematic review with direct and network me...See full text at original site
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引用元：
https://doi.org/10.1111/add.13974

データ提供：米国国立医学図書館（NLM）

Pharmacologically Controlled Drinking: A Comparative Review of Medications

This systematic review explores the effectiveness of various medications used in the treatment of alcohol dependence or alcohol use disorders (AUDs). The researchers embarked on a comprehensive search through the vast desert of medical literature to compare the efficacy of nalmefene, naltrexone, acamprosate, baclofen, and topiramate. This research is like navigating a complex network of trails, seeking to identify the most effective paths to recovery for individuals struggling with alcohol dependence.

Limited Evidence for Pharmacologically Controlled Drinking

The review found no high-grade evidence to support the use of any of the medications studied for pharmacologically controlled drinking. The results suggest that while some treatments may offer modest benefits in reducing alcohol consumption, their effectiveness is limited. It's like traversing a challenging terrain, where the path to recovery may not always be clear or straightforward.

A Need for Further Research in Alcohol Dependence Treatment

This review highlights the urgent need for further research into effective pharmacological treatments for alcohol dependence or AUDs. The authors emphasize the importance of high-quality clinical trials to provide clear evidence and guide treatment decisions. It's like seeking a reliable map through the complex landscape of alcohol dependence treatment, ensuring the most effective and compassionate care for patients.

Dr. Camel's Conclusion

This review underscores the complexity of alcohol dependence treatment, reminding us that the journey to recovery is often challenging. While the evidence for pharmacologically controlled drinking is limited, further research is crucial to identify effective treatments and support patients on their path to recovery. It's like seeking a reliable map through the complex landscape of alcohol dependence treatment, ensuring the most effective and compassionate care for patients.

Date :
  1. Date Completed 2019-10-15
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

28940866

DOI: Digital Object Identifier

10.1111/add.13974

Related Literature

Article Analysis
・Effective treatment of alcohol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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