Effective treatment of alcohol: A Synthesis of Findings from 80 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of alcohol: A Synthesis of Findings from 80 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

There are a variety of approaches used in the treatment of alcohol addiction. Many studies have been conducted on pharmacotherapy, behavioral therapy, psychotherapy, and 12-step programs, but a full understanding of their effectiveness is still lacking.

Recent studies, such as 78 , suggest that hemodialysis is effective in treating acute severe alcohol intoxication. Hemodialysis reduces alcohol levels in the blood, reducing the risk of coma and other complications. Additionally, 38 , suggests that alcohol use can be a barrier to recovery from drug dependence. Therefore, avoiding alcohol use is critical in the treatment of alcohol addiction.

Furthermore, 50 investigates the preliminary finding that the sweet-liking (SL) phenotype interacts with a high level of craving for alcohol and is associated with an improved response to naltrexone in alcohol dependence. This research suggests that combining the SL phenotype and a strong craving for alcohol leads to a stronger response to naltrexone. Naltrexone is a drug that reduces alcohol cravings and rewards. These studies show that it is essential to choose the appropriate treatment approach for each individual patient.

Treatment Summary

78 shows that hemodialysis is effective in treating acute severe alcohol intoxication. It is recommended that hemodialysis be performed with conventional treatment and nalmefene.

22 shows that naltrexone is effective in treating alcohol addiction. Naltrexone is more effective when combined with psychotherapy, such as cognitive behavioral therapy.

46 advocates for integrated treatment for patients with alcohol addiction and co-occurring psychiatric disorders such as anxiety or depression. Integrated treatment aims to treat mental illness and alcohol addiction concurrently for more effective treatment.

64 introduces 12-step programs as a recovery program for alcohol addiction. 12-step programs are self-help group programs that support recovery from alcohol addiction.

68 advocates for adaptive interventions in the treatment of alcohol addiction. Adaptive interventions are treatment methods that adjust treatment content and methods based on the patient's condition and response.

Benefits and Risks

Benefit Summary

Treating alcohol addiction can significantly change a patient's life. Receiving treatment can provide the following benefits.

  • Recovery from alcohol addiction
  • Reduction in alcohol-related problems
  • Improvement in quality of life
  • Improvement in physical health
  • Improvement in work and relationships

Risk Summary

Treating alcohol addiction also carries risks.

  • Treatment may not be effective in all cases
  • There is a possibility of side effects during treatment
  • Treatment can be expensive

Comparison Between Studies

Commonalities in Studies

Many studies have shown that treatment for alcohol addiction is effective for patients. However, treatment methods and effectiveness vary from patient to patient.

Differences in Studies

The treatment methods and study subjects vary depending on the study, so the results obtained also vary. For example, 78 examines the effectiveness of hemodialysis for acute severe alcohol intoxication. On the other hand, 22 examines the effectiveness of treatment that combines naltrexone and psychotherapy.

Consistency and Contradictions in Results

There are both consistencies and contradictions in the research findings on the treatment of alcohol addiction. For example, 22 shows that treatment combining naltrexone and psychotherapy is effective, while 46 shows that integrated treatment is effective. These research findings suggest that multiple factors influence the treatment of alcohol addiction.

Cautions Regarding Applications in Real Life

It is crucial to treat alcohol addiction with the appropriate method tailored to each individual patient. When choosing a treatment method, it is essential to consider the patient's symptoms, past treatment history, and living environment.

Limitations of Current Research

Research on the treatment of alcohol addiction is still insufficient. In particular, there is a lack of research on long-term treatment effectiveness and comparative studies of various treatment methods. Additionally, as research subjects often have different backgrounds and symptoms, applying research findings directly to real life is challenging.

Future Research Directions

Further research on the treatment of alcohol addiction is needed in the following directions.

  • Verification of long-term treatment effectiveness
  • Comparative studies of various treatment methods
  • Development of optimal treatment methods tailored to the characteristics of individual patients

Conclusion

Alcohol addiction is a treatable illness. Receiving treatment can significantly change a patient's life. While treatment carries risks, the benefits outweigh the risks. Further research on the treatment of alcohol addiction is expected to lead to the development of even more effective treatment methods.

If you are struggling with alcohol addiction, don't hesitate to seek professional help.

Treatment List

Hemodialysis, Nalmefene, Cognitive Behavioral Therapy, Psychotherapy, Integrated Treatment, 12-Step Program, Adaptive Intervention

Keywords
Benefit Keywords
Reduced alcohol consumption
1
Alcohol consumption reduction
2
Alcohol dependence treatment
3
Increased days abstinent
Reduced alcohol consumption
4
Drinking behavior improved
5
Reduced drinking
7
Effective treatment
8
Alcohol relapse reduction
Drinking frequency decrease
9
Alcohol dependence treatment
11
Alcohol dependence treatment
12
Improved employment
Reduced alcohol consumption
13
Alcohol-related problems treatment
14
Alcohol dependence treatment
15
Alcohol dependence treatment
Smoking cessation
16
Alcohol consumption reduction
17
Treat alcoholism
18
Heavy drinking reduction
19
Reduce drinking
20
Naltrexone reduces craving
21
Alcohol dependence treatment
22
Improved alcohol use disorder
24
Improved nondrinking outcomes
Improved quality of life
26
Alcohol dependence treatment
27
Reduced alcohol dependence
28
Reduced drinking days
Reduced heavy drinking
29
Reduced alcohol euphoria
30
Alcohol use reduction
31
Reduced seizures
32
Reduced alcohol dependence
33
Alcohol dependence treatment
34
Increased treatment initiation
35
Treatment of alcohol dependence
36
Effective treatment of alcohol problems
37
Abstinence from alcohol
39
Alcohol harm reduction
40
Alcohol consumption reduction
41
Health benefits
Lifestyle interventions
Reduced healthcare utilization
42
Reduced alcohol consumption
43
Alcohol use disorder treatment
45
Improved treatment outcomes
46
Formal alcohol treatment
48
Improved AUDIT score
Reduced alcohol consumption
49
Improved response to naltrexone
Increased abstinence
Reduced heavy drinking
50
AUD treatment
51
Alcohol use disorder treatment
53
Reduced relapse
54
Reduced alcohol consumption
55
Alcohol dependence treatment
56
AUD treatment
57
Reduced alcohol use
Reduced drug use
58
Reduced alcohol use
59
Reduced injury
60
Reduced alcohol consumption
61
Improved alcohol dependence treatment
62
Reduced drinking problems
63
AUD recovery
64
Access to treatment
ICBT treatment
65
Improved alcohol use disorder treatment
66
AUD treatment
67
AUD treatment
68
Alcohol craving reduction
69
Increased abstinence rate
70
AUD treatment
MAT
71
AUD treatment
72
Reduced alcohol consumption
Reduced relapse
73
AUD treatment
Exercise
74
AUD treatment
75
Increased Engagement
Reduced Alcohol Use
76
Telephone-delivered interventions for problem alcohol use
77
Alcohol intoxication
78
Improved alcohol control
79
Alcohol use reduction
Treatment seeking
80
Risk Keywords
Dropouts
1
None mentioned
2
None mentioned
3
Dermatitis
Diarrhea
Fatigue
Headache
Pruritus
12
Dizziness
Fatigue
Insomnia
Malaise
Nausea
19
Acamprosate does not reduce craving
21
No differential effectiveness between treatment combinations
26
Treatment adherence
27
Gastrointestinal issues
Sedative effects
29
Side effects
32
Relapse
Substitute addiction
38
Treatment experience bias
44
Treatment engagement
45
Alcohol problems
Treatment goals
47
Alcohol Use Disorders
48
Alcohol dependence
54
None
76
Literature analysis of 80 papers
Positive Content
73
Neutral Content
5
Negative Content
2
Article Type
60
12
14
12
79
1.

A comparison of behavioral and traditional treatment for middle-income problem drinkers.

Author: PomerleauO, PertschukM, AdkinsD, BradyJ P

Reduced alcohol consumption
Dropouts

A study comparing two treatments for problem drinkers found that both a positive reinforcement approach emphasizing moderation and a traditional denial-confrontation approach emphasizing abstinence resulted in significant reductions in alcohol consumption. However, the positive reinforcement group showed greater improvement in several outcome measures and had a lower dropout rate. The study suggests that the effects of traditional therapy were mixed, with some patients benefitting while others dropped out. The improvement in the traditional group appeared to be more due to initial therapist demands than the actual therapy itself. The study supports the effectiveness of positive reinforcement techniques in treating problem drinking.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

What happens to drinking after therapeutic intervention?

Author: DuckertF, AmundsenA, JohnsenJ

Alcohol consumption reduction
None mentioned

A study of 135 individuals with problem drinking compared the effectiveness of brief counseling and short-term group therapy. While the group therapy group showed a greater initial reduction in alcohol consumption, this effect was not maintained over time. After 21 months, there was no significant difference in alcohol consumption, liver enzyme levels (GGT), deaths, or hospitalizations between the two groups. Overall, the study found that both treatments resulted in a significant long-term reduction in alcohol consumption. After 21 months, half of the participants had reduced their alcohol consumption by more than 50%, with significant reductions in the frequency of drinking, heavy drinking episodes, and alcohol intake during moderate drinking weeks. However, there was little change in the amount consumed during heavy drinking episodes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Naltrexone and coping skills therapy for alcohol dependence. A controlled study.

Author: O'MalleyS S, JaffeA J, ChangG, SchottenfeldR S, MeyerR E, RounsavilleB

Alcohol dependence treatment
None mentioned

A study of 97 patients with alcohol dependence found that naltrexone was more effective than placebo in reducing drinking and alcohol-related problems, including the number of drinking days, relapses, and severity of problems. The study also found that the type of psychotherapy received influenced the effectiveness of naltrexone. Naltrexone combined with supportive therapy resulted in the highest rate of abstinence, while naltrexone with coping skills therapy was most effective in preventing relapse for patients who did start drinking.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

A comparison of minimal versus intensive controlled drinking treatment interventions for problem drinkers.

Author: RobertsonI, HeatherN, DzialdowskiA, CrawfordJ, WintonM

Increased days abstinent
Reduced alcohol consumption

A study of 37 problem drinkers compared the effectiveness of intensive cognitive-behavioral therapy to minimal treatment (assessment and advice). The intensive group showed significantly greater reductions in alcohol consumption and increased days of abstinence compared to the minimal group. Women in the intensive group showed a significantly greater increase in abstinence days and reduced drinking days. While successful outcomes were associated with higher pre-treatment employment and alcohol consumption, these findings may have occurred by chance due to the large number of variables measured.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Effects of outpatient treatment for problem drinkers.

Author: MaistoS A, SobellL C, SobellM B, SandersB

Drinking behavior improved

A study of 48 male alcohol abusers found that neither treatment length restriction nor follow-up interview style had a significant impact on drinking behavior or employment outcomes. However, all participants showed improvements in drinking behavior after treatment. While drinking patterns could be predicted within treatment and post-treatment periods, pre-treatment drinking did not predict post-treatment drinking. These findings suggest that while treatment may be beneficial for improving drinking behavior, predicting long-term outcomes based on pre-treatment patterns may be challenging.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Effects of short-term rehabilitation on alcohol consumption and drinking-related behaviors: an eight-month follow-up study of drunken drivers.

Author: SwensonP R, ClayT R

Short-term alcohol treatment intervention did not improve the quality of life for social or problem drinkers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

7.

Changes in alcohol expectancies and drinking behavior among treated problem drinkers.

Author: ConnorsG J, TarboxA R, FaillaceL A

Reduced drinking

This study of male and female problem drinkers participating in an outpatient treatment found a significant relationship between decreases in alcohol expectancies and decreased drinking, particularly at an 18-month follow-up.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

Current strategies for the treatment of alcohol dependence in the United States.

Author: O'MalleyS S

Effective treatment

This study highlights advancements in treating alcoholism, recognizing the need for combined approaches that include medication. Research indicates that the use of medications like naltrexone and nalmefene, which block opioid receptors, is effective in preventing relapse for many people with alcohol dependence. This underscores the importance of pharmacotherapy in addition to psychotherapy in treating alcoholism.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

Pharmacological treatment of alcohol dependence: a review of the evidence.

Author: GarbuttJ C, WestS L, CareyT S, LohrK N, CrewsF T

Alcohol relapse reduction
Drinking frequency decrease

Naltrexone reduces the risk of relapse to heavy drinking and the frequency of drinking compared with placebo but does not substantially enhance abstinence. Acamprosate reduces drinking frequency. Controlled studies of disulfiram reveal a mixed outcome pattern. The limited data on serotonergic agents were not very promising, and lithium lacks efficacy in the treatment of primary alcohol dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

Meta-Analysis of social relationships and posttreatment drinking outcomes: comparison of relationship structure, function and quality.

Author: BeattieM C

This study examined the association between social relationships and drinking outcomes in alcoholism treatment programs. The researchers investigated the importance of addressing interpersonal factors alongside intrapersonal factors in treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

[Outpatient behavioural treatment in alcoholism: alcohol consumption and sociodemographic factors].

Author: BurtscheidtW, SchwarzR, WölwerW, GaebelW

Alcohol dependence treatment

This study compared the effectiveness of different behaviour therapy strategies for alcohol dependents. It found that behavioural therapy resulted in less drop-outs and significantly higher rates of abstinence, reemployment, and job satisfaction compared to supportive therapy. Employment status was a valid predictor of treatment success, while the presence of a partner had a weak negative impact on abstinence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results from a non-blind, multicentre study.

Author: SoykaMichael, PreussUlrich, SchuetzChristian

Alcohol dependence treatment
Dermatitis
Diarrhea
Fatigue
Headache
Pruritus

Abstinence rates with integrated acamprosate and psychosocial support were similar to those seen in placebo-controlled clinical trials of acamprosate. The safety profile of acamprosate was good.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

A trial of "standard" outpatient alcoholism treatment vs. a minimal treatment control.

Author: DavisWilliam T, CampbellLarry, TaxJudith, LieberCharles S

Improved employment
Reduced alcohol consumption

A standard outpatient alcoholism treatment program (ST) was found to be more effective than minimal treatment (MT) in treating severely alcohol-dependent individuals. ST patients showed better outcomes in terms of complete abstinence, reduced alcohol consumption, longer sobriety at follow-up, improved employment status, and higher attendance at Alcoholics Anonymous (AA) meetings. The study found that individuals who were already drinking less benefited from MT.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

14.

Short-term treatment for alcohol-related problems: four-session guided self-change versus one session of advice--a randomized, controlled trial.

Author: AndréassonSven, HansagiHelen, OsterlundBill

Alcohol-related problems treatment

A four-session guided self-change group treatment was found to be as effective as a one-session advice group in reducing alcohol consumption, dependence, and negative consequences of drinking, but patients were more satisfied with the longer treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Effectiveness of naltrexone in a community treatment program.

Author: KilleenTherese K, BradyKathleen T, GoldPaul B, SimpsonKit N, FaldowskiRichard A, TysonClare, AntonRaymond F

Alcohol dependence treatment

Naltrexone, an opiate antagonist, has shown efficacy in reducing alcohol use in alcohol-dependent individuals, but further research is needed to confirm its effectiveness in front-line community treatment programs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

A randomized trial of concurrent versus delayed smoking intervention for patients in alcohol dependence treatment.

Author: JosephAnne M, WillenbringMark L, NugentSean M, NelsonDavid B

Alcohol dependence treatment
Smoking cessation

The study compared the effects of concurrent smoking treatment and intensive treatment for alcohol dependence with delayed smoking treatment, highlighting the reluctance to treat tobacco dependence concurrently with alcohol dependence due to concerns about jeopardizing drinking outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Is alcohol assessment therapeutic? Pretreatment change in drinking among alcohol-dependent women.

Author: EpsteinElizabeth E, DrapkinMichelle L, YuskoDavid A, CookSharon M, McCradyBarbara S, JensenNoelle K

Alcohol consumption reduction

This study examines the reduction in drinking days during the pretreatment assessment period in a clinical trial of cognitive-behavioral therapy (CBT) for alcohol-dependent women, investigating potential reactivity to assessment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

[The effectiveness of psychosocial treatment approaches for alcohol dependence--a review].

Author: BottlenderM, KöhlerJ, SoykaM

Treat alcoholism

This article reviews randomized-controlled studies/meta-analysis on the efficacy of different treatment approaches for inpatient alcoholism treatment, identifying effective, ineffective, and potentially counterproductive interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

19.

Targeted nalmefene with simple medical management in the treatment of heavy drinkers: a randomized double-blind placebo-controlled multicenter study.

Author: KarhuvaaraSakari, SimojokiKaarlo, VirtaAntti, RosbergMarkus, LöyttyniemiEliisa, NurminenTommi, KallioAntero, MäkeläRauno

Heavy drinking reduction
Dizziness
Fatigue
Insomnia
Malaise
Nausea

Nalmefene, an opioid antagonist, was found to be effective and safe in reducing heavy drinking, even when minimal psychosocial support was provided. This multisite, randomized, double-blind study involving 403 patients with problem drinking found that nalmefene significantly reduced the number of heavy drinking days compared to placebo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Randomized-controlled trial of a telephone and mail intervention for alcohol use disorders: three-month drinking outcomes.

Author: BrownRichard L, SaundersLaura A, BobulaJames A, MundtMarlon P, KochPaul E

Reduce drinking

Alcohol screening, brief intervention, and referral to specialized treatment (ASBIR) can reduce drinking and related harms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Do acamprosate or naltrexone have an effect on daily drinking by reducing craving for alcohol?

Author: RichardsonKylie, BaillieAndrew, ReidSophie, MorleyKirsten, TeessonMaree, SannibaleClaudia, WeltmanMartin, HaberPaul

Naltrexone reduces craving
Acamprosate does not reduce craving

Naltrexone had a greater effect on drinking in alcohol-dependent individuals when craving was high. Acamprosate did not show a significant effect on craving in this study.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention.

Author: OslinDavid W, LynchKevin G, PettinatiHelen M, KampmanKyle M, GaritiPeter, GelfandLois, Ten HaveThomas, WortmanShoshana, DundonWilliam, DackisCharles, VolpicelliJoseph R, O'BrienCharles P

Alcohol dependence treatment

This study examined the impact of 3 types of psychosocial treatment combined with either naltrexone or placebo treatment on alcohol dependency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

23.

An intervention for treating alcohol dependence: relating elements of Medical Management to patient outcomes with implications for primary care.

Author: ErnstDenise B, PettinatiHelen M, WeissRoger D, DonovanDennis M, LongabaughRichard

This study examined the relationship between patient and clinician factors and treatment outcomes in patients receiving a medically oriented intervention for alcohol dependence. The intervention was developed for the COMBINE Study, a randomized controlled trial comparing two medications (naltrexone and acamprosate) with or without specialty alcohol treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

24.

Factors mediating the association between drinking in the first year after alcohol treatment and drinking at three years.

Author: MaistoStephen A, CliffordPatrick R, StoutRobert L, DavisChristine M

Improved alcohol use disorder

This study investigated mediators of the relationship between alcohol consumption in the first year following alcohol treatment admission and longer-term functioning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

25.

Characteristics of first-time alcohol treatment seekers: the COMBINE Study.

Author: LocastroJoseph S, PotterJennifer Sharpe, DonovanDennis M, CouperDavid, PopeKimberly W

This study compared alcoholics who entered treatment for the first time with those who had reported one or more prior treatment experiences.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

26.

Alcohol treatment effects on secondary nondrinking outcomes and quality of life: the COMBINE study.

Author: LoCastroJoseph S, YoungbloodMarston, CislerRon A, MattsonMargaret E, ZwebenAllen, AntonRaymond F, DonovanDennis M

Improved nondrinking outcomes
Improved quality of life
No differential effectiveness between treatment combinations

Treatment for alcohol dependence improved nondrinking functional outcomes, but specific pharmacological and behavioral treatment combinations were not differentially effective on specific secondary outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

27.

The role of alcoholic beverage preference in the severity of alcohol dependence and adherence to the treatment.

Author: BaltieriDanilo Antonio, DaróFábio R, RibeiroPhilip L, De AndradeArthur G

Alcohol dependence treatment
Treatment adherence

This study focused on the types of beverages preferentially consumed by alcohol-dependent outpatients and their effects on the severity of dependence and therapeutic outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Alcohol misuse.

Author: CoultonSimon

Reduced alcohol dependence

This review covers interventions in hazardous or harmful but not dependent alcohol users.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Opioid antagonists for alcohol dependence.

Author: RösnerSusanne, Hackl-HerrwerthAndrea, LeuchtStefan, VecchiSimona, SrisurapanontManit, SoykaMichael

Reduced drinking days
Reduced heavy drinking
Gastrointestinal issues
Sedative effects

This review of 50 randomized controlled trials found that naltrexone was effective in reducing heavy drinking and drinking days in patients with alcohol dependence. The review also found that naltrexone was well-tolerated, with gastrointestinal problems and sedative effects being the most common side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype.

Author: SetiawanElaine, PihlRobert O, CoxSylvia M L, GianoulakisChristina, PalmourRoberta M, BenkelfatChawki, LeytonMarco

Reduced alcohol euphoria

Naltrexone decreases positive subjective effects of alcohol, particularly in women and subjects with the A118G polymorphism of the mu opioid receptor gene.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Alcohol misuse.

Author: CoultonSimon

Alcohol use reduction

Alcohol use is a major health concern globally. This review examines interventions for hazardous or harmful alcohol use, but not alcohol dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome.

Author: AmatoLaura, MinozziSilvia, DavoliMarina

Reduced seizures
Side effects

This review summarizes Cochrane reviews that assess the effectiveness and safety of pharmacological interventions for alcohol withdrawal. Benzodiazepines showed a protective benefit against seizures when compared to placebo and a potentially protective benefit when compared to antipsychotics. However, the quality of evidence was moderate or low for most comparisons, preventing definitive conclusions about the effectiveness and safety of benzodiazepines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Alcohol misuse.

Author: CoultonSimon

Reduced alcohol dependence

This review examines interventions for hazardous or harmful alcohol use, but not alcohol dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC).

Author: OwensLynn, ButcherGraham, GilmoreIan, Kolamunnage-DonaRuwanthi, OyeeJames, PerkinsLiz, WalleyTom, WilliamsonPaula, WilsonKen, PirmohamedMunir

Alcohol dependence treatment

Alcohol dependence affects 3% of the English population, but only a small percentage seek treatment. Because people with alcohol dependence often visit hospitals, this setting could be a key point for offering treatment. This study aims to assess the effectiveness of treatment interventions offered in hospitals to people with alcohol dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

An intervention to increase alcohol treatment engagement: a pilot trial.

Author: SteckerTracy, McGovernMark P, HerrBeverly

Increased treatment initiation

A brief, cognitive-behavioral intervention delivered by telephone, focused on modifying treatment-interfering beliefs, was successful in increasing alcohol treatment seeking among individuals in need. Intervention participants were almost three times more likely to attend treatment than the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Assertive Community Treatment for alcohol dependence (ACTAD): study protocol for a randomised controlled trial.

Author: GilburtHelen, BurnsTom, CopelloAlex, CoultonSimon, CrawfordMichael, DayEd, DelucaPaolo, GodfreyChristine, ParrottSteve, RoseAbigail K, SinclairJulia M A, WrightChristine, DrummondColin

Treatment of alcohol dependence

Alcohol dependence is a major issue in the UK, but only a small percentage of those affected seek treatment. Traditional approaches focused on individual choice and motivation have limited success in engaging this population. Assertive Community Treatment (ACT), a model used for mental health patients, shows promise for reaching individuals with alcohol dependence who are difficult to engage in traditional treatment. However, research in this area is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

The effectiveness of psychosocial modalities in the treatment of alcohol problems in adults: a review of the evidence.

Author: MartinGarth W, RehmJürgen

Effective treatment of alcohol problems

Motivational enhancement therapy, cognitive-behavioral interventions, and brief interventions have been proven effective in treating alcohol use disorders. These interventions are comparable in effectiveness and suggest a low-to-moderate range of effect sizes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

38.

Overlooked and underestimated? Problematic alcohol use in clients recovering from drug dependence.

Author: StaigerPetra K, RichardsonBen, LongCaroline M, CarrVictoria, MarlattG Alan

Relapse
Substitute addiction

Alcohol misuse can interfere with sustained recovery from drug dependency, but it has been overlooked in drug treatment research. This study investigates whether concurrent alcohol use can impede recovery from illicit drug use in two ways: by becoming a substitute addiction and/or by increasing the risk of relapse to the primary drug problem.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

The effects of drinking goal on treatment outcome for alcoholism.

Author: BujarskiSpencer, O'MalleyStephanie S, LunnyKaty, RayLara A

Abstinence from alcohol

This study investigated the contribution of drinking goal to treatment outcome in alcohol-dependent individuals enrolled in a large, multisite trial. A goal of complete abstinence was associated with the best outcomes, followed by conditional abstinence; controlled drinking was associated with the poorest outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Managed alcohol as a harm reduction intervention for alcohol addiction in populations at high risk for substance abuse.

Author: MuckleWendy, MuckleJamie, WelchVivian, TugwellPeter

Alcohol harm reduction

Managed alcohol programs (MAPs) are a harm reduction approach to alcohol dependence that provides a structured way for individuals to consume alcohol safely while accessing support services. Instead of focusing on abstinence, MAPs work with individuals to set personalized drinking goals and address the risks associated with their behavior, ultimately aiming to reduce harm to both the individual and society.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene.

Author: MannKarl, BladströmAnna, TorupLars, GualAntoni, van den BrinkWim

Alcohol consumption reduction

Nalmefene, an opioid system modulator, was found to be effective in reducing alcohol consumption in patients with alcohol dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

An alcohol-focused intervention versus a healthy living intervention for problem drinkers identified in a general hospital setting (ADAPTA): study protocol for a randomized, controlled pilot trial.

Author: WatsonJudith, ToberGillian, RaistrickDuncan, MdegeNoreen, DaleVeronica, CrosbyHelen, GodfreyChristine, LloydCharlie, TonerPaul, ParrottSteve,

Health benefits
Lifestyle interventions
Reduced healthcare utilization

Alcohol misuse is a major health problem, but many people with alcohol problems don't seek help. Hospital admissions offer an opportunity to encourage people to seek specialized treatment, which can improve health and reduce healthcare costs. This study aims to determine if offering a choice of healthy lifestyle interventions (rather than just focusing on alcohol) is more appealing and effective in engaging people with alcohol problems in treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Pretreatment alcohol drinking goals are associated with treatment outcomes.

Author: DunnKelly E, StrainEric C

Reduced alcohol consumption

Participants who chose an abstinent drinking goal had significantly more weeks with no drinking or no heavy drinking, reported fewer heavy drinking days, reported fewer days with >1 drink, and were more likely to have a ≥50% decrease in drinks per day.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

44.

Treatment may influence self-report and jeopardize our understanding of outcome.

Author: NirenbergTed, LongabaughRichard, BairdJanette, MelloMichael J

Treatment experience bias

This study examined whether the reliability of the Alcohol Use Disorders Identification Test (AUDIT) was affected by exposure to motivational interviewing (MI) or community service (CS).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

45.

A randomized clinical trial of alcohol care management delivered in Department of Veterans Affairs primary care clinics versus specialty addiction treatment.

Author: OslinDavid W, LynchKevin G, MaistoStephen A, LantingaLarry J, McKayJames R, PossematoKyle, IngramErin, WierzbickiMichael

Alcohol use disorder treatment
Treatment engagement

Alcohol use disorder is a significant health problem worldwide. While effective treatments exist, many people with this condition don't seek help. This study highlights the importance of primary care physicians in identifying, treating, and supporting patients with alcohol use disorder, suggesting that primary care plays a crucial role in improving outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

46.

Integrated care for comorbid alcohol dependence and anxiety and/or depressive disorder: study protocol for an assessor-blind, randomized controlled trial.

Author: MorleyKirsten C, BaillieAndrew, SannibaleClaudia, TeessonMaree, HaberPaul S

Improved treatment outcomes

Comorbid psychiatric conditions are a significant barrier to successful alcohol dependence treatment. Patients with comorbid major depression or anxiety disorders experience shorter relapse times, higher drop-out rates, and greater long-term alcohol consumption compared to those with alcohol use disorder without comorbid mental disorders. Integrated treatment approaches are crucial to address both alcohol dependence and comorbid anxiety and/or depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Predictors of pretreatment commitment to abstinence: results from the COMBINE study.

Author: DeMartiniKelly S, DevineEric G, DiClementeCarlo C, MartinDaniel J, RayLara A, O'MalleyStephanie S

Alcohol problems
Treatment goals

Treatment goals for alcohol problems vary among patients, and pretreatment drinking goals significantly impact treatment outcomes. This study investigates the relationship between individual characteristics and pretreatment drinking goals in patients entering alcohol treatment. The research aims to better understand factors influencing treatment goals and improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

48.

Interventions for Increasing Subsequent Alcohol Treatment Utilisation Among Patients with Alcohol Use Disorders from Somatic Inpatient Settings: A Systematic Review.

Author: SimioniN, CottencinO, RollandB

Formal alcohol treatment
Alcohol Use Disorders

Alcohol misuse is common in hospitals, but brief interventions to reduce drinking are often ineffective. This review examined research on ways to encourage people with alcohol problems to seek specialized treatment during hospital stays.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Guided and Unguided Internet-Based Treatment for Problematic Alcohol Use - A Randomized Controlled Pilot Trial.

Author: SundströmChristopher, GajeckiMikael, JohanssonMagnus, BlankersMatthijs, SinadinovicKristina, Stenlund-GensErik, BermanAnne H

Improved AUDIT score
Reduced alcohol consumption

Adding counselor guidance to an Internet-based self-help program for problematic alcohol use significantly reduced alcohol consumption and improved outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

Association of the Sweet-Liking Phenotype and Craving for Alcohol With the Response to Naltrexone Treatment in Alcohol Dependence: A Randomized Clinical Trial.

Author: GarbuttJames C, Kampov-PolevoyAlexey B, Kalka-JuhlLinda S, GallopRobert J

Improved response to naltrexone
Increased abstinence
Reduced heavy drinking

The sweet-liking phenotype and a high craving for alcohol independently and particularly in combination are associated with a positive response to naltrexone in patients with alcohol dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels.

Author: WitkiewitzKatie, HallgrenKevin A, KranzlerHenry R, MannKarl F, HasinDeborah S, FalkDaniel E, LittenRaye Z, O'MalleyStephanie S, AntonRaymond F

AUD treatment

Alcohol use disorder (AUD) is a major public health problem with significant costs. While complete abstinence is often the goal of treatment, many people may prefer to reduce their drinking. This research suggests that using a measure of reduced alcohol consumption, specifically a decrease in the World Health Organization (WHO) risk levels of drinking, could be a useful way to evaluate the effectiveness of alcohol treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

52.

Heterogeneity in pathways to abstinence among women in treatment for alcohol use disorder.

Author: HolzhauerCathryn Glanton, EpsteinElizabeth E, CohnAmy M, McCradyBarbara S, GraffFiona S, CookSharon

This study examines a unique abstinence planning intervention in a cognitive behavioral therapy (CBT) protocol for treating alcohol use disorders (AUD). The study focuses on strategies to help patients achieve abstinence, a key step in AUD treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study.

Author: WitkiewitzKatie, WilsonAdam D, PearsonMatthew R, HallgrenKevin A, FalkDaniel E, LittenRaye Z, KranzlerHenry R, MannKarl F, HasinDeborah S, O'MalleyStephanie S, AntonRaymond F

Alcohol use disorder treatment

This study discusses the FDA's proposed expansion of primary endpoints for alcohol use disorder medication development, including both abstinence and nonheavy drinking outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

54.

A proof-of-concept investigation into ketamine as a pharmacological treatment for alcohol dependence: study protocol for a randomised controlled trial.

Author: McAndrewAmy, LawnWill, StevensTobias, PorffyLilla, BrandnerBrigitta, MorganCelia J A

Reduced relapse
Alcohol dependence

This non-commercial proof-of-concept trial aimed to assess the effectiveness of a combined repeated ketamine and psychological therapy program for reducing relapse in severe alcohol use disorder.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate.

Author: PalpacuerClément, DuprezRenan, HuneauAlexandre, LocherClara, BoussageonRémy, LaviolleBruno, NaudetFlorian

Reduced alcohol consumption

There is currently no high-quality evidence to support the use of any pharmacological treatment to control drinking in patients with alcohol dependence or alcohol use disorder. Some treatments showed low to medium efficacy in reducing drinking, but none demonstrated any benefit on health outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Antidepressants for the treatment of people with co-occurring depression and alcohol dependence.

Author: AgabioRoberta, TroguEmanuela, PaniPier Paolo

Alcohol dependence treatment

This abstract highlights the challenges of treating alcohol dependence, emphasizing the high prevalence of major depression in people seeking treatment and its negative impact on outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials: A Secondary Analysis of 3 Randomized Clinical Trials.

Author: FalkDaniel E, O'MalleyStephanie S, WitkiewitzKatie, AntonRaymond F, LittenRaye Z, SlaterMegan, KranzlerHenry R, MannKarl F, HasinDeborah S, JohnsonBankole, MeulienDidier, RyanMegan, FertigJoanne,

AUD treatment

The US Food and Drug Administration considers complete abstinence from alcohol and no heavy drinking days as successful outcomes for alcohol use disorder (AUD) medications. However, many people struggle to achieve these goals, which discourages them from seeking treatment and has slowed the development of new medications that help with alcohol use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

58.

Interventions to Reduce Unhealthy Alcohol Use among Primary Care Patients with HIV: the Health and Motivation Randomized Clinical Trial.

Author: SatreDerek D, LeibowitzAmy S, LeydenWendy, CatzSheryl L, HareC Bradley, JangHannah, LamJennifer O, BryantKendall J, WeisnerConstance M, SterlingStacy A, HorbergMichael, VolberdingPaul, SilverbergMichael J

Reduced alcohol use
Reduced drug use

In a randomized trial of HIV-positive patients with unhealthy alcohol use, motivational interviewing (MI) was found to be more effective than emailed feedback (EF) or treatment as usual (UC) in reducing unhealthy alcohol use among patients with low motivation. MI also had a positive effect on reducing illegal drug use. All three interventions led to a decrease in unhealthy alcohol use and alcohol-related problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

59.

A Digital Intervention Addressing Alcohol Use Problems (the "Daybreak" Program): Quasi-Experimental Randomized Controlled Trial.

Author: TaitRobert J, Paz CastroRaquel, KirkmanJessica Jane Louise, MooreJamie Christopher, SchaubMichael P

Reduced alcohol use

The Daybreak program, a mobile app and desktop program designed to support individuals looking to change their relationship with alcohol, was associated with significant reductions in alcohol use, alcohol risk, and days out of role.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Alcohol-related trauma reinjury prevention with hospital-based screening in adult populations: An Eastern Association for the Surgery of Trauma evidence-based systematic review.

Author: KodadekLisa M, FreemanJennifer J, TiwaryDevesh, DrakeMack Dillon, SchroederM Elizabeth, DultzLinda, WhiteCassandra, Abdel AzizHiba, CrandallMarie, ComoJohn J, RattanRishi

Reduced injury

This review highlights the importance of addressing alcohol use among injured patients to prevent recurrent injury or death. While many trauma centers incorporate alcohol screening, brief intervention, and referral to treatment, systematic reviews evaluating the impact of these interventions are lacking.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Changes in alcohol consumption after treatment for depression: a secondary analysis of the Swedish randomised controlled study REGASSA.

Author: StridCatharina, HallgrenMats, ForsellYvonne, KraepelienMartin, ÖjehagenAgneta

Reduced alcohol consumption

This study examines the impact of treatment for depression on alcohol consumption patterns. The research will analyze whether alcohol consumption changes after treatment and if these changes vary based on the type of treatment received and patient gender.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

The efficacy of iCBT added to treatment as usual for alcohol-dependent patients in primary care: study protocol for a randomized controlled trial.

Author: HylandKarin, HammarbergAnders, Hedman-LagerlöfErik, JohanssonMagnus, AndreassonSven

Improved alcohol dependence treatment

This study investigates the use of screening and brief interventions for alcohol dependence in primary care, addressing the hesitancy of general practitioners (GPs) to engage in treating alcohol problems.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

63.

A behavioral activation intervention administered in a 16-week freshman orientation course: Study protocol.

Author: FazzinoTera L, LejuezCarl W, YiRichard

Reduced drinking problems

Behavioral activation (BA), a therapy that focuses on engaging in reinforcing activities, may be a promising approach to reduce alcohol-related problems in college freshmen, particularly during the transition to college when they may be resistant to direct interventions targeting drinking.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

64.

Alcoholics Anonymous and other 12-step programs for alcohol use disorder.

Author: KellyJohn F, HumphreysKeith, FerriMarica

AUD recovery

Alcohol use disorder (AUD) causes significant problems, including premature death, injuries, crime, and increased healthcare costs. Alcoholics Anonymous (AA) has been helping people recover from AUD for over 80 years, but only recently has its effectiveness been rigorously studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Optimizing internet-delivered cognitive behaviour therapy for alcohol misuse: a study protocol for a randomized factorial trial examining the effects of a pre-treatment assessment interview and health educator guidance.

Author: SundströmChristopher, HadjistavropoulosHeather, WilhelmsAndrew, KeoughMatt, SchaubMichael

Access to treatment
ICBT treatment

This study discusses the potential of internet-delivered cognitive behaviour therapy (ICBT) as a treatment alternative for individuals with alcohol misuse who are reluctant to seek traditional face-to-face treatment. The study explores the benefits of pre-treatment assessment interviews and therapist guidance in optimizing ICBT delivery within routine clinic settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

66.

Practice facilitation to promote evidence-based screening and management of unhealthy alcohol use in primary care: a practice-level randomized controlled trial.

Author: HuffstetlerAlison N, KuzelAnton J, SaboRoy T, RichardsAlicia, BrooksE Marshall, Lail KashiriPaulette, VillalobosGabriela, AriasAlbert J, SvikisDace, BortzBeth A, EdwardsAshley, EplingJohn, CohenDeborah J, ParchmanMichael L, WinterJonathan, WesslerPatricia, YuTimothy J, KristAlex H

Improved alcohol use disorder treatment

This study discussed the importance of screening and brief interventions for unhealthy alcohol use in primary care settings, as well as medication-assisted therapy (MAT) for moderate or severe alcohol use disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Controlled drinking-non-abstinent versus abstinent treatment goals in alcohol use disorder: a systematic review, meta-analysis and meta-regression.

Author: HensslerJonathan, MüllerMartin, CarreiraHelena, BschorTom, HeinzAndreas, BaethgeChristopher

AUD treatment

Many people with alcohol use disorder (AUD) don't get treatment. A new approach is to explore controlled drinking strategies, rather than complete abstinence. This review will compare the effectiveness of treatments that don't require complete abstinence to those that do.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

An efficacy trial of adaptive interventions for alcohol use disorder.

Author: MorgensternJon, KuerbisAlexis, ShaoSijing, PadovanoHayley Treloar, LevakSvetlana, VadhanNehal P, LynchKevin G

AUD treatment

Adaptive interventions, also known as 'stepped care', are interventions in which the type or dosage of treatment is tailored to the patient's clinical presentation and adjusted over time based on their progress. Currently, there are no adaptive brief interventions specifically for alcohol use disorder (AUD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

69.

Relapse prevention for alcohol use disorders: combined acamprosate and cue exposure therapy as aftercare.

Author: StryhnLene, LarsenMathias Bach, MejldalAnna, SibbersenChristian, NielsenDorthe Grüner, NielsenBent, NielsenAnette Søgaard, StenagerElsebeth, MellentinAngelina Isabella

Alcohol craving reduction

Cue exposure therapy (CET) and acamprosate are both effective treatments for alcohol cravings. Combining CET with acamprosate may be as effective as either treatment alone or aftercare as usual (AAU) with acamprosate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

70.

Transcranial direct current stimulation combined with alcohol cue inhibitory control training reduces the risk of early alcohol relapse: A randomized placebo-controlled clinical trial.

Author: DubusonMacha, KornreichCharles, VanderhasseltMarie-Anne, BaekenChris, WyckmansFlorent, DoussetClémence, HanakCatherine, VeeserJohannes, CampanellaSalvatore, ChatardArmand, JaafariNemat, NoëlXavier

Increased abstinence rate

This randomized clinical trial found that transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) led to a significantly higher abstinence rate in alcohol use disorder (AUD) patients during the weeks following rehabilitation. Combining tDCS with alcohol cue inhibitory control training may provide better clinical outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Pharmacological interventions for alcohol misuse in correctional settings: A systematic review.

Author: Slavin-StewartClaire, MinhasMeenu, TurnaJasmine, BraschJennifer, OlagunjuAndrew Toyin, ChaimowitzGary, MacKillopJames

AUD treatment
MAT

Alcohol use disorder (AUD) is much more common in the criminal justice system than in the general population. It's also a major factor that increases the chance of reoffending. Medication-assisted treatment (MAT) is a proven way to reduce alcohol use, but we need to see how well it works for people in prison. This review will examine research on MAT for AUD in correctional settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

The Relationship Between Reductions in WHO Risk Drinking Levels During Treatment and Subsequent Healthcare Costs for the ACTIVE Workgroup.

Author: AldridgeArnie P, ZarkinGary A, DowdWilliam N, WitkiewitzKatie, HasinDeborah S, O'MalleyStephanie S, IsenbergKeith, AntonRaymond F

AUD treatment

While complete abstinence has been the goal of alcohol use disorder (AUD) treatment, studies show that even reducing alcohol intake to safer levels can significantly improve people's lives, including their health, well-being, and ability to function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

73.

A Personalized Approach Bias Modification Smartphone App ("SWiPE") to Reduce Alcohol Use: Open-Label Feasibility, Acceptability, and Preliminary Effectiveness Study.

Author: ManningVictoria, PiercyHugh, GarfieldJoshua Benjamin Bernard, ClarkStuart Gregory, AndrabiMah Noor, LubmanDan Ian

Reduced alcohol consumption
Reduced relapse

Approach bias modification (ApBM), a cognitive intervention that helps people avoid alcohol-related images, has shown promise in reducing alcohol relapse. This study explores the potential of smartphone-delivered ApBM as a readily accessible intervention for individuals with alcohol problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

Effects of exercise in non-treatment seeking adults with alcohol use disorder: A three-armed randomized controlled trial (FitForChange).

Author: GunillasdotterVictoria, AndréassonSven, JirweMaria, EkblomÖrjan, HallgrenMats

AUD treatment
Exercise

This study examined the effects of exercise (aerobic and yoga) and standard support on alcohol consumption in people with alcohol use disorder (AUD) who are not actively seeking treatment. The researchers aimed to determine if exercise could be a helpful approach for those who are not engaging in traditional treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

75.

Alcohol-related consequences and the intention to seek care in treatment naïve women and men with severe alcohol use disorder.

Author: ConnerKenneth R, AbarBeau, AldalurAileen, ChiangAndrew, HutchisonMorica, MaistoStephen A, SteckerTracy

AUD treatment

This study will look at people with severe alcohol use disorder (AUD) who aren't currently in treatment to understand why they might be more likely to seek help. It will examine if the consequences of alcohol use, rather than how much they drink, are linked to their willingness to get treatment. The study will also look at whether these factors affect men and women differently.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

76.

Integration of alcohol and drug nurses into a mental health unit.

Author: SolarAnn M, BennettKellie, HulseGary

Increased Engagement
Reduced Alcohol Use
None

This single-blind randomized controlled trial evaluated the effectiveness of two interventions delivered by alcohol and drug nurses for inpatients at a Mental Health Unit (MHU). Patients received either a brief information pack (BIP) or extra time with the nurses. The BIP group showed a significant reduction in alcohol use post-discharge.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

77.

Effectiveness of a Stand-alone Telephone-Delivered Intervention for Reducing Problem Alcohol Use: A Randomized Clinical Trial.

Author: LubmanDan I, GriggJasmin, ReynoldsJohn, HallKate, BakerAmanda L, StaigerPetra K, TylerJonathan, VolpeIsabelle, StragalinosPeta, HarrisAnthony, BestDavid, ManningVictoria

Telephone-delivered interventions for problem alcohol use

Despite the widespread problem of alcohol misuse, treatment uptake remains low. Telephone-delivered interventions offer a promising approach to address barriers to seeking help, but their effectiveness as a standalone treatment needs further research.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

78.

Role of Hemodialysis in Acute Severe Alcohol Intoxication: A Meta-Analysis.

Author: ZengSiyao, MaLei, YangLishan, HuXiaodong, WangCheng, GuoXinxin, LiYi, GouYi

Alcohol intoxication

The use of hemodialysis on the basis of conventional treatment and naloxone for acute severe alcohol intoxication can reduce the length of hospital stay, coma time, time of symptom disappearance, and the incidence of some complications rate.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

80.

Brief, cognitive-behavioral intervention to promote treatment seeking in adults with severe alcohol use disorder: A randomized controlled trial.

Author: ConnerKenneth R, MaistoStephen A, AbarBeau, SzafranskiSarah, ChiangAndrew, HutchisonMorica, AldalurAileen, SteckerTracy

Alcohol use reduction
Treatment seeking

This study aims to determine if a brief intervention can encourage people with severe alcohol use disorder (AUD) who haven't sought treatment to do so, and whether seeking treatment leads to reduced alcohol use.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

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