Paper Details

  1. Home
  2. Paper Details

Tolerance and rebound during and after short-term administration of quazepam, triazolam and placebo to healthy human volunteers.

Author: LaderM, LeeA

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Quazepam and triazolam both improved sleep quality in healthy volunteers, but had different effects on performance and side effects. Quazepam improved motor performance, while triazolam impaired it. Both drugs increased bodily symptoms and sedation.
Paper Details　
Original Abstract of the Article :
Quazepam 15 mg, triazolam 0.25 mg and placebo were administered to 12 healthy volunteers. Each drug was given for 14 nights using a balanced design with at least 28 days between drug administrations. A test battery of physiological, psychological and subjective measures was administered on the morni...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00004850-198801000-00002

データ提供：米国国立医学図書館（NLM）

Exploring the Effects of Quazepam and Triazolam: A Tolerance and Rebound Study

This study aimed to investigate the effects of quazepam and triazolam, two commonly prescribed sedative-hypnotic medications, on healthy human volunteers. The researchers administered quazepam, triazolam, and placebo to 12 volunteers over a 14-night period. They assessed various physiological, psychological, and subjective measures before, during, and after drug administration. The study found that quazepam and triazolam improved sleep quality but also led to an increase in bodily symptoms and sedation. The researchers observed little evidence of tolerance to drug effects on EEG or psychomotor tests but did find tolerance to bodily symptoms and mood ratings. The study also found no convincing evidence of rebound after drug discontinuation.

The Complex Effects of Sedative-Hypnotics

This study underscores the intricate effects of sedative-hypnotics on the human body. It's like observing a desert ecosystem – the introduction of a new element can have unforeseen consequences. The researchers found that while these medications can improve sleep quality, they can also have unintended effects on mood, bodily symptoms, and cognitive function. This study highlights the importance of careful monitoring and individualized treatment plans for sedative-hypnotics.

Navigating the Use of Sedative-Hypnotics

This study emphasizes the need to carefully consider the potential risks and benefits of using sedative-hypnotics. While these medications can be helpful for managing sleep disorders, it's essential to be aware of their potential side effects and to work with a healthcare professional to develop a safe and effective treatment plan. The research encourages a cautious approach to the use of these medications, recognizing that their effects can vary greatly from person to person.

Dr. Camel's Conclusion

This study explores the effects of quazepam and triazolam on healthy volunteers, demonstrating their impact on sleep quality, bodily symptoms, and mood. The research highlights the importance of understanding the potential risks and benefits of these medications and underscores the need for individualized treatment plans to optimize their therapeutic effects while minimizing potential adverse events.
Date :
  1. Date Completed 1988-05-26
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

2895786

DOI: Digital Object Identifier

10.1097/00004850-198801000-00002

Related Literature

Article Analysis
・Effects of triazolam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.