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Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid.

Author: Aghazadeh-HabashiAli, AsgharWaheed, JamaliFakhreddin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inflammation can disrupt the balance of vasodilator and vasoconstrictor components of the renin-angiotensin system, increasing cardiovascular risk. This study examined the effects of inflammation and nonsteroidal anti-inflammatory drugs (NSAIDs) on the metabolism of arachidonic acid (ArA) in rats with adjuvant arthritis.
Paper Details　
Original Abstract of the Article :
Inflammatory conditions increase cardiovascular (CV) risk. Some nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and inflammation are also associated with CV complications. Inflammation, but not NSAIDs, disrupts the balance of vasodilator and vasoconstrictor components of th...See full text at original site
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引用元：
https://doi.org/10.1016/j.xphs.2017.09.020

データ提供：米国国立医学図書館（NLM）

The Impact of Inflammation and NSAIDs on Arachidonic Acid Metabolism

This study delves into the intricate relationship between inflammation, nonsteroidal anti-inflammatory drugs (NSAIDs), and the metabolism of arachidonic acid (ArA), a key player in the inflammatory process. The research focuses on how inflammation and different NSAIDs affect the balance of ArA metabolites, which play crucial roles in cardiovascular health.

NSAIDs Can Disrupt the Balance of ArA Metabolites

The study revealed that inflammation, particularly in the context of adjuvant arthritis, disrupted the balance of ArA metabolites, leading to an increase in the ratio of cardiotoxic 20-hydroxyeicosatetraenoic acid to cardioprotective epoxyeicosatrienoic acids in the heart. Rofecoxib, an NSAID with known cardiotoxicity, further exacerbated this imbalance. These findings suggest that NSAIDs can differentially impact ArA metabolism, potentially influencing cardiovascular risk.

Potential Implications for Cardiovascular Safety

This research highlights the importance of considering the impact of NSAIDs on ArA metabolism when assessing their cardiovascular safety. The findings suggest that specific NSAIDs, such as rofecoxib, might be associated with a greater risk of cardiovascular complications due to their influence on ArA metabolism. This information is crucial for guiding the selection of NSAIDs for patients, particularly those at increased risk for cardiovascular disease.

Dr.Camel's Conclusion

This study uncovers the complex interplay between inflammation, NSAIDs, and arachidonic acid metabolism, highlighting the potential for NSAIDs to disrupt the balance of cardiovascular-protective and cardiovascular-toxic metabolites. This research underscores the importance of understanding the nuances of drug-disease interactions and their impact on patient health. The insights gained from this study can help inform the development of safer and more targeted therapies for inflammatory conditions, minimizing the risk of cardiovascular complications.

Date :
  1. Date Completed 2018-09-11
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28989019

DOI: Digital Object Identifier

10.1016/j.xphs.2017.09.020

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