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Topical beta-blocker therapy and central nervous system side effects. A preliminary study comparing betaxolol and timolol.

Author: BrownR H, DrakeM M, LynchM G, NguyenH, WhitsonJ T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Betaxolol may be a safer alternative to timolol for patients with central nervous system (CNS) side effects from topical beta-blockers. Sixteen out of 18 patients switched from timolol to betaxolol experienced improvement in their CNS symptoms.
Paper Details　
Original Abstract of the Article :
Topical beta-blocking agents have been associated with adverse central nervous system (CNS) effects, including depression, emotional lability, and sexual dysfunction. Two studies were done to determine if patients who develop CNS effects while using timolol maleate would improve with betaxolol hydro...See full text at original site
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引用元：
https://doi.org/10.1001/archopht.1988.01060140054023

データ提供：米国国立医学図書館（NLM）

Beta-Blockers and the Brain: Navigating the Desert of Central Nervous System Effects

The desert of medicine is full of surprises, and sometimes, even a seemingly simple treatment can have unexpected side effects. This study explores the potential central nervous system (CNS) effects of topical beta-blocking agents, commonly used for the treatment of glaucoma. The researchers compared betaxolol hydrochloride with timolol maleate, investigating whether switching to betaxolol could improve CNS symptoms experienced by patients using timolol.

A Shifting Oasis: Finding Relief from CNS Side Effects

The study found that 16 out of 18 patients experienced symptomatic improvement after switching from timolol to betaxolol. In a double-masked crossover study, two patients experienced complete resolution of their CNS symptoms with betaxolol, while three experienced improvement. The results suggest that there may be an advantage to using a selective beta-blocker, like betaxolol, for patients experiencing CNS side effects.

The Desert of Beta-Blockers: Navigating the Side Effects

Although the exact mechanisms by which beta-blockers affect the CNS are not fully understood, this study suggests that certain beta-blockers may be better tolerated by some patients. It is important to be aware of potential side effects and to consult with a healthcare professional if you experience any adverse effects while taking beta-blockers. The desert of medicine can be unpredictable, and it's important to have a skilled guide by your side.

Dr.Camel's Conclusion

Just as a camel must navigate the shifting sands of the desert, we must be mindful of the potential side effects of medications. This study underscores the importance of individual differences and the need for personalized treatment approaches. Remember, a skilled guide can help you find the oasis of relief in the desert of medication side effects.

Date :
  1. Date Completed 1988-08-04
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

2898932

DOI: Digital Object Identifier

10.1001/archopht.1988.01060140054023

Related Literature

Article Analysis
・Side Effects of betaxolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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