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The efficacy of the addition of nifedipine in patients with mixed angina compared to patients with classic exertional angina: a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Author: BodenW E, DeWoodM A, EichR H, GoreJ M, NestoR W, ParisiA F, PietroD A, SharmaS C, StoneP H, WareJ H

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the effectiveness of adding nifedipine to existing treatments for angina in 72 patients with stable chest pain. Patients were categorized as having either “classic exertional angina” (stable chest pain triggered by exercise) or “mixed angina” (chest pain triggered by varying levels of exercise and/or at rest). The study found that nifedipine was more effective in reducing chest pain and medication use in patients with mixed angina compared to those with classic exertional angina. While both groups showed improved exercise tolerance, only patients with mixed angina had a reduction in the frequency of silent heart attacks during nifedipine treatment. The study suggests that patients with mixed angina may benefit more from nifedipine, but that other factors besides coronary artery spasms may contribute to their chest pain.
Paper Details　
Original Abstract of the Article :
Episodes of myocardial ischemia in patients with coronary artery disease may be due to transient increases in coronary vasomotor tone superimposed on a fixed atherosclerotic obstruction. The purpose of this study was to determine whether identification of the clinical pattern of angina could predict...See full text at original site
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引用元：
https://doi.org/10.1016/0002-8703(88)90146-9

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1988-11-07
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

2902779

DOI: Digital Object Identifier

10.1016/0002-8703(88)90146-9

Related Literature

Article Analysis
・Effective treatment of angina
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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