Paper Details 
Original Abstract of the Article :
The oral administration of water-soluble chemotherapeutical agents is limited by their serious gastrointestinal side effects, instability at intestinal pH, and poor absorption. Aiming to solve these problems, we chose topotecan (TPT) as a model drug and developed a novel lipid formulation containing...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241165/

データ提供:米国国立医学図書館(NLM)

A Novel Approach to Delivering Chemotherapeutics

In the world of cancer treatment, scientists are always seeking new ways to improve the effectiveness of chemotherapy. This research, like a caravan seeking a new route across the desert, explores a novel approach to delivering water-soluble chemotherapeutics orally. The authors have developed a core-shell lipid nanoparticle (CLN) formulation that encapsulates the drug, shielding it from harsh conditions and promoting its absorption into the body. This innovative approach promises to enhance drug efficacy and minimize side effects, offering a more tolerable and effective treatment experience for cancer patients.

The Promise of CLN Formulation for Drug Delivery

This research demonstrates the potential of CLN formulation in enhancing the oral delivery of water-soluble chemotherapeutics. The nanoparticle's unique structure acts like a protective oasis in the harsh desert of the gastrointestinal tract, ensuring the drug reaches its target with minimal degradation. The study's results, showing improved drug absorption and reduced side effects, are truly encouraging, suggesting that this novel formulation could significantly improve the lives of cancer patients.

Minimizing Side Effects and Optimizing Drug Delivery

This research provides hope for a future where chemotherapy treatments are more effective and less debilitating. The innovative CLN formulation, like a well-stocked caravan, delivers the drug efficiently while minimizing its negative effects. This approach to drug delivery could significantly enhance the quality of life for cancer patients while maximizing the effectiveness of chemotherapy.

Dr.Camel's Conclusion

This research presents an intriguing new approach to delivering water-soluble chemotherapeutics, offering a potential oasis in the challenging landscape of cancer treatment. The CLN formulation promises to improve drug absorption, reduce side effects, and ultimately enhance the effectiveness of chemotherapy, paving the way for a more promising future for cancer patients.

Date :
  1. Date Completed 2018-02-05
  2. Date Revised 2021-07-09
Further Info :

Pubmed ID

29029577

DOI: Digital Object Identifier

PMC8241165

Related Literature

SNS
PICO Info
in preparation
Languages

English

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