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Strength in Amalgamation: Newer Combination Agents for HIV and Implications for Practice.

Author: , BadowskiMelissa, ChastainDaniel B, CrutchleyRustin, McCoyChristopher, ShermanElizabeth, SmithEthan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Single-tablet regimens (STRs) and fixed-dose combinations (FDCs) have significantly improved antiretroviral therapy (ART) for HIV infection. Newer STRs and FDCs with integrase strand transfer inhibitors (INSTIs) offer faster virologic suppression, reduced resistance, and better adherence compared to older regimens. This review highlights the efficacy and safety data for these newer agents, discussing the potential benefits of reduced side effects and drug-drug interactions.
Paper Details　
Original Abstract of the Article :
Antiretroviral (ART) therapy for the treatment of human immunodeficiency virus (HIV) infection has undergone significant changes over the past 30 years. Many single-tablet regimens (STRs), including newer fixed-dose combination (FDC) tablets, are available, offering patients several options for choo...See full text at original site
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引用元：
https://doi.org/10.1002/phar.2055

データ提供：米国国立医学図書館（NLM）

Combating HIV: New Combinations for Improved Treatment

The field of [HIV treatment] is constantly evolving, with researchers developing new drug combinations to improve [virologic suppression], [adherence], and [quality of life] for individuals living with HIV. This study reviews the latest developments in [antiretroviral therapy (ART)], highlighting the emergence of [newer combination agents] and their implications for clinical practice.

Combating HIV: New Combinations for Improved Treatment

The study highlights the significant advancements made in [HIV treatment], particularly the development of [single-tablet regimens (STRs)] and [fixed-dose combination (FDC) tablets]. These advancements have led to improved [treatment adherence], [clinical outcomes], and a reduction in [side effects] and [drug-drug interactions]. The study also discusses the emergence of new [integrase strand transfer inhibitor (INSTI)]-based STRs, which offer [faster rates of virologic suppression], [reduced resistance development], and [improved adherence] compared to older regimens.

Combating HIV: New Combinations for Improved Treatment

This review offers a comprehensive overview of the latest developments in [HIV treatment], showcasing the increasing efficacy and safety of [newer combination agents]. The study's findings suggest that these advancements have significantly improved the lives of individuals living with HIV. As research continues to progress, we can expect even more innovative treatments to emerge, further enhancing the quality of life for those living with HIV.

Dr. Camel's Conclusion

Just as camels are known for their resilience in traversing vast deserts, we are witnessing a remarkable resilience in the fight against HIV. This research underscores the incredible advancements in HIV treatment, offering new hope and improved quality of life for those living with this complex and challenging disease.

Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

29105160

DOI: Digital Object Identifier

10.1002/phar.2055

SNS
PICO Info
in preparation
Languages

English

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