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Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis.

Author: BaiZemin, ChenLi, ElliottJesse, JohnstonAmy, KellyShannon E, KotbAhmed, MamdaniMuhammad, MillarAdam C, PetersonJoan, SkidmoreBecky, WellsGeorge A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Testosterone replacement therapy (TRT) has a class effect of improving quality of life, depression, erectile function, and libido in hypogonadal men. However, no individual testosterone product consistently demonstrated superiority in improving these outcomes. There was no statistically significant increase in the risk of adverse events, but longer-term, high-quality trials are needed to fully assess the risks of harm.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess the relative effects of individual testosterone products among hypogonadal men. DESIGN: Systematic review and network meta-analysis. METHODS: We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (25 May 2017) for randomised-controlled trials (RCTs) and non-random...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701987/

データ提供：米国国立医学図書館（NLM）

Testosterone Therapy in Hypogonadal Men: A Comprehensive Review

Testosterone therapy is a vast and complex topic, like a desert with a rich history of different approaches. This systematic review and network meta-analysis meticulously examines the effects of various testosterone products in hypogonadal men, comparing them against placebo and other treatment options. The study evaluates a wide range of outcomes, including quality of life, depression, libido, erectile function, and overall health. While the findings demonstrate a class effect of improvement in several areas, the researchers emphasize the need for longer-term high-quality trials to fully understand the risks and benefits of different testosterone products.

Testosterone Therapy Shows Promise for Quality of Life, Libido, and Depression

The review reveals a class effect of testosterone therapy, demonstrating improvements in quality of life, libido, and depression compared to placebo. While this is a significant finding, the study also highlights the need for further research to understand the long-term impact of testosterone therapy on overall health. Think of this research as a camel caravan traversing a desert – each camel represents a different testosterone product, and while the journey has yielded positive results, further exploration is needed to fully understand the path ahead.

Cautious Approach to Testosterone Therapy: Balancing Risks and Benefits

The study emphasizes the need for caution in using testosterone therapy, particularly considering the potential for adverse events and the need for longer-term studies. This approach is like navigating a desert – while the oasis may hold promise, it's wise to approach with caution, understanding the potential challenges and risks involved.

Dr.Camel's Conclusion

This study offers valuable insights into the complex landscape of testosterone therapy for hypogonadal men. Like exploring a desert, it is crucial to weigh the potential benefits against the risks and proceed with caution. Further research is essential for understanding the long-term impact of testosterone therapy and developing personalized treatment plans that maximize benefits while minimizing risks.
Date :
  1. Date Completed 2018-07-05
  2. Date Revised 2023-11-12
Further Info :

Pubmed ID

29150464

DOI: Digital Object Identifier

PMC5701987

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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