Combination of disopyramide and mexiletine for better tolerance and additive effects for treatment of ventricular arrhythmias.

Author: FisherJ D, KimS G, MercandoA D, TamS

Paper Details 
Original Abstract of the Article :
The efficacy and tolerance of disopyramide and mexiletine used alone and in combination were studied in 21 patients with frequent (greater than or equal to 30/h) ventricular premature complexes. Ambulatory electrocardiographic monitoring was performed at baseline and during therapy with disopyramide...See full text at original site
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引用元:
https://doi.org/10.1016/0735-1097(89)90608-6

データ提供:米国国立医学図書館(NLM)

Exploring the Synergy of Disopyramide and Mexiletine for Ventricular Arrhythmias

This research dives into the realm of cardiology, specifically focusing on the treatment of ventricular arrhythmias. The study employed a meticulous approach, utilizing ambulatory electrocardiographic monitoring to assess the efficacy and tolerance of disopyramide and mexiletine, both individually and in combination, in patients experiencing frequent ventricular premature complexes. The researchers delved into the intricate dance between these drugs, uncovering their potential to work harmoniously to achieve a greater therapeutic effect. Their findings revealed that the combination therapy led to a significantly greater reduction in ventricular premature complexes compared to either drug used alone. This synergy, like a captivating duet in a symphony, showcased the powerful effect of combining these antiarrhythmic agents.

A Glimpse into the Power of Combination Therapy

The results of this study shed light on the potential of combining disopyramide and mexiletine in treating ventricular arrhythmias. The combination therapy demonstrated a statistically significant advantage in reducing the number of ventricular premature complexes per hour, indicating a more effective approach compared to using either drug individually. This finding resonates with the concept of synergy, where the combined effect of two elements is greater than the sum of their individual effects. It's like a desert oasis, where the combination of water and shade creates a life-sustaining haven, exceeding the benefits of each element alone.

Navigating the Landscape of Antiarrhythmic Therapies

This research serves as a valuable compass in the vast landscape of antiarrhythmic therapies. The study underscores the importance of considering combination therapies when treating ventricular arrhythmias. The synergistic effect observed in this study suggests that combining drugs might be a key to unlocking enhanced treatment outcomes. As we journey deeper into the complexities of cardiac health, research like this provides crucial insights that can guide us towards more effective and personalized treatment strategies.

Dr. Camel's Conclusion

This research is a testament to the power of combining forces, demonstrating that two antiarrhythmic drugs can work together to achieve better outcomes than either drug alone. It's a reminder that sometimes, the best solutions lie in exploring the synergy between different elements, just like the convergence of diverse desert flora and fauna creates a rich ecosystem. While further investigation is needed, this study provides a promising starting point for exploring the potential of combination therapy in tackling ventricular arrhythmias.
Date :
  1. Date Completed 1989-04-05
  2. Date Revised 2019-07-08
Further Info :

Pubmed ID

2918173

DOI: Digital Object Identifier

10.1016/0735-1097(89)90608-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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