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Compound action potential inhibition produced by various antidepressants in the frog sciatic nerve.

Author: FujitaTsugumi, HiraoRyo, KumamotoEiichi, SakaiAiko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Six antidepressants (duloxetine, fluoxetine, amitriptyline, desipramine, maprotiline, and trazodone) inhibited nerve conduction in frog sciatic nerves, with half-maximal inhibitory concentration (IC<sub>50</sub>) values comparable to some antiepileptics, α<sub>2</sub>-adrenoceptor agonists, and local anesthetics. This suggests that antidepressants can inhibit nerve conduction with similar efficacy to other analgesic adjuvants.
Paper Details　
Original Abstract of the Article :
Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2017.11.047

データ提供：米国国立医学図書館（NLM）

Antidepressants: A Hidden Oasis in the Desert of Pain

Antidepressants, often used to treat mood disorders, are increasingly being explored for their potential to relieve pain. This study investigated the effects of various antidepressants on compound action potentials (CAPs), a measure of nerve conduction, in frog sciatic nerves. The research found that several antidepressants, including duloxetine, fluoxetine, amitriptyline, desipramine, maprotiline, and trazodone, inhibited CAPs, suggesting a potential mechanism for their analgesic effects. These findings provide valuable insights into the pain-relieving properties of antidepressants, adding to our understanding of their therapeutic actions.

Exploring the Desert of Pain Relief

This research explores the fascinating interplay between mood and pain, highlighting the potential of antidepressants to provide relief from pain. It's like navigating the vast desert of pain relief, seeking effective solutions for individuals experiencing chronic pain. The findings suggest that antidepressants, through their ability to modulate nerve conduction, may play a significant role in pain management, offering hope for those suffering from chronic pain conditions.

Finding Relief in the Desert

This research sheds light on the potential of antidepressants to provide pain relief, offering a glimmer of hope for individuals struggling with chronic pain. It's like discovering a hidden oasis in the desert of pain, providing respite and healing for those seeking relief from debilitating pain. The findings encourage further investigation into the analgesic properties of antidepressants, potentially leading to new and effective treatment strategies for chronic pain conditions.

Dr. Camel's Conclusion

This study provides a valuable glimpse into the potential of antidepressants for pain management. It's like finding a hidden wellspring in the vast and unforgiving desert of pain, offering a potential source of relief for those seeking effective treatment. The research underscores the importance of exploring the multifaceted effects of antidepressants, potentially leading to new and innovative approaches to pain management.
Date :
  1. Date Completed 2018-08-06
  2. Date Revised 2018-08-06
Further Info :

Pubmed ID

29203420

DOI: Digital Object Identifier

10.1016/j.ejphar.2017.11.047

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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