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Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers.
Author: Del Río-SanchoSergio, KaliaYogeshvar N, KandekarSomnath G, LaptevaMaria
Original Abstract of the Article :
Drug delivery systems that target the pilosebaceous unit (PSU) selectively could improve the clinical management of diseases that originate in the hair follicle. The aims of this study were (i) to prepare polymeric micelles using d-α-tocopheryl polyethylene glycol succinate diblock copolymer th...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1039/c7nr07706h
データ提供:米国国立医学図書館(NLM)
Delivering Adapalene to the Hair Follicle: A Camel's Journey Through the Desert of Skin Care
The skin, like a vast desert landscape, is a complex and intricate organ, with each follicle representing a unique oasis. This research explores the potential of polymeric micelle nanocarriers to selectively deliver adapalene, a retinoid used to treat acne, to the hair follicle. The researchers developed micelle formulations that significantly enhanced the aqueous solubility of adapalene and demonstrated its preferential delivery to the hair follicle in both porcine and human skin. This targeted delivery approach could lead to more effective treatment of acne and other follicular diseases, minimizing off-site side effects.A New Oasis in the Desert of Skin Care: Exploring Targeted Delivery of Adapalene
This research offers a promising solution for delivering adapalene to the hair follicle, the primary target for treating acne. By using polymeric micelle nanocarriers, the researchers have achieved significantly improved solubility and targeted delivery, potentially leading to more effective treatment with fewer side effects. This innovative approach could revolutionize the way we treat acne and other follicular diseases.Navigating the Desert of Skin Health: A Camel's Perspective on Personalized Skin Care
Skin health, like a delicate desert ecosystem, requires a personalized approach. This research highlights the importance of developing targeted delivery systems that address the specific needs of different skin conditions. By understanding the intricate mechanisms of skin health and disease, researchers are seeking to develop more effective and less invasive treatments, offering a brighter future for individuals with skin disorders.Dr. Camel's Conclusion
This study offers a compelling demonstration of the potential of targeted drug delivery for treating skin diseases. The researchers' development of polymeric micelle nanocarriers for adapalene delivery could significantly improve the effectiveness and safety of acne treatment. As we continue to explore the vast desert of dermatological research, we gain valuable insights that can guide us towards more personalized and effective treatments for a wide range of skin conditions.Date :
- Date Completed 2018-12-28
- Date Revised 2018-12-28
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