Paper Details

  1. Home
  2. Paper Details

Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN.

Author: CaoSijia, MatsubaraJoanne A, RajapakseSanjeeva, XuQinyuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study explores the commonalities between age-related macular degeneration (AMD), Alzheimer's disease, atherosclerosis, and glomerulonephritis, suggesting that understanding these shared pathways might provide insights into AMD etiology.
Paper Details　
Original Abstract of the Article :
Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly. Due to its complex etiology, current treatments have been insufficient. Previous studies reveal three systems closely involved in AMD pathogenesis: lipid metabolism, oxidation and inflammation. These ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755337/

データ提供：米国国立医学図書館（NLM）

Age-Related Macular Degeneration: Understanding the Common Threads

The field of [age-related macular degeneration (AMD)] research is constantly seeking a deeper understanding of this complex and debilitating eye condition. This study examines the potential for understanding [AMD] by comparing its pathogenesis to that of [Alzheimer's disease, atherosclerosis, and glomerulonephritis].

Shared Pathogenic Mechanisms: A Cross-Disease Perspective

The study explores the commonality of [lipid metabolism, oxidation, and inflammation] in the pathogenesis of [AMD, Alzheimer's disease, atherosclerosis, and glomerulonephritis]. The researchers propose that by understanding the shared mechanisms underlying these diseases, researchers might gain valuable insights into the etiology of [AMD].

Unveiling the Complexity: New Insights into AMD

The study's findings highlight the interconnectedness of these seemingly distinct diseases, suggesting that a deeper understanding of the [lipid-related pathogenic mechanisms] shared by these conditions could lead to new therapeutic targets for [AMD]. This approach may offer a new perspective on [AMD] treatment and contribute to the development of more effective therapies.

Dr.Camel's Conclusion

The challenge of understanding [AMD] is like navigating a vast and complex desert, where seemingly disparate elements are intertwined. This study provides a compelling perspective on the value of looking beyond the boundaries of individual diseases, demonstrating the power of cross-disciplinary research in unlocking new insights and potential treatments for [AMD].

Date :
  1. Date Completed 2018-08-06
  2. Date Revised 2023-11-12
Further Info :

Pubmed ID

29301530

DOI: Digital Object Identifier

PMC5755337

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.