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Head to head comparison of adverse effects and efficacy between high dose deflazacort and high dose prednisolone in systemic lupus erythematosus: a prospective cohort study.
Author: DandaD, DavidT, GanapatiA, JeyaseelanL, JeyaseelanV, RavindranR, YadavB
Original Abstract of the Article :
BACKGROUND: Deflazacort (DFZ), an oxazoline derivative of prednisolone (PDN), has a dose equivalence of 1.2:1 (mg) to PDN. No study to date has compared adverse effects and efficacy of high doses of DFZ as against high-dose PDN in systemic lupus erythematosus (SLE). OBJECTIVES: To compare adverse e...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1177/0961203317751854
データ提供:米国国立医学図書館(NLM)
Deflazacort vs. Prednisolone: A Desert Oasis of Treatment Options
The treatment of [systemic lupus erythematosus (SLE)] often involves [corticosteroids], but finding the right type and dose can be a challenging journey. This study compares the adverse effects and efficacy of [deflazacort] and [prednisolone], two commonly used corticosteroids, in patients with SLE. It's like exploring different routes across a vast desert, seeking the most effective and least burdensome path to manage the condition.
Deflazacort: A Potential Advantage in Managing SLE
The study found that high doses of deflazacort were associated with lower weight gain, hirsutism, and cushingoid features compared to prednisolone, while maintaining similar efficacy. This is like finding a desert oasis with less sand and more water: providing relief from the adverse effects of traditional corticosteroids.
Potential for Personalized Treatment
The study suggests that deflazacort may be a viable alternative to prednisolone in the treatment of SLE, potentially offering a less burdensome option with similar efficacy. It's like discovering a new route across the desert: providing a more comfortable and efficient journey to manage the condition.
Dr.Camel's Conclusion
This research offers a new oasis in the desert of SLE treatment, highlighting the potential benefits of deflazacort over prednisolone. It's a step towards finding more personalized and effective treatment options for this complex and challenging condition.
Date :
- Date Completed n.d.
- Date Revised 2020-05-25
Further Info :
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