Effects of deflazacort: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major research findings

Deflazacort is a synthetic glucocorticoid that has been shown to have fewer adverse effects on bone metabolism, weight gain, and Cushing’s syndrome compared to prednisolone. 4 , 2 , 19 , 10 Deflazacort has been shown to be less effective in suppressing bone formation than prednisolone, suggesting it may have bone-sparing properties. 8 , 13 Deflazacort has been suggested to have a stronger immunosuppressive effect than prednisolone. 3 Deflazacort has also been shown to have less of an impact on blood lipid levels compared to prednisolone. 10 , 5 Studies have indicated that deflazacort may have a less negative effect on growth velocity than prednisolone. 5 , 15 , 11 In some studies, deflazacort has been observed to have a smaller impact on blood glucose levels than prednisolone. 16 Some research suggests that deflazacort may have a less significant effect on liver IGF-I and growth hormone receptor mRNA levels compared to prednisolone. 14

Benefits and Risks

Benefit Summary

Deflazacort has been shown to have a favorable profile compared to prednisolone in terms of bone metabolism, weight gain, and Cushing’s syndrome. It may also have less of an impact on blood lipid levels and growth velocity. Deflazacort could potentially have less of an effect on blood glucose levels. 4 , 2 , 19 , 10 , 8 , 13 , 3 , 10 , 5 , 15 , 11 , 16 , 14

Risk Summary

Deflazacort may have a stronger immunosuppressive effect than prednisolone, leading to a potential increase in the risk of opportunistic infections. 3

Comparison of Studies

Commonalities

Several studies have demonstrated that deflazacort shows fewer adverse effects on bone metabolism, weight gain, and Cushing’s syndrome compared to prednisolone. 4 , 2 , 19 , 10 Additionally, a majority of the research indicates that deflazacort has a smaller impact on blood lipid levels. 10 , 5

Differences

Findings regarding the strength of deflazacort’s immunosuppressive effect and its impact on growth velocity vary across different studies. 3 5 , 15 , 11 These discrepancies may stem from variations in research design and participant characteristics.

Consistency and Contradictions of Findings

A significant portion of the research suggests that deflazacort has a more favorable profile than prednisolone in terms of bone metabolism, weight gain, and Cushing’s syndrome. 4 , 2 , 19 , 10 However, findings concerning the strength of deflazacort’s immunosuppressive effect and its impact on growth velocity vary across studies. 3 5 , 15 , 11 These inconsistencies could be attributed to differences in research design and participant characteristics.

Points to Consider for Real-World Application

Deflazacort may offer advantages over prednisolone in terms of bone metabolism, weight gain, and Cushing’s syndrome. 4 , 2 , 19 , 10 However, the potential for a stronger immunosuppressive effect with deflazacort, leading to an elevated risk of opportunistic infections, should be carefully considered. 3 When using deflazacort, a thorough evaluation of the risks and benefits is crucial.

Current Limitations of Research

The current body of research on deflazacort is still limited. Research on long-term safety and efficacy is particularly lacking. 3 Additionally, results concerning deflazacort’s immunosuppressive effect and its impact on growth velocity vary between studies. 3 5 , 15 , 11 These inconsistencies could be attributed to differences in research design and participant characteristics.

Future Research Directions

To gain a better understanding of deflazacort’s long-term safety and efficacy, larger clinical trials are needed. Furthermore, studies should be designed to provide a more precise comparison of the immunosuppressive effects of deflazacort and prednisolone, and their respective impacts on growth velocity. 3 5 , 15 , 11 To achieve this, research designs and participant characteristics should be standardized across studies.

Conclusion

Deflazacort may offer advantages over prednisolone in terms of bone metabolism, weight gain, and Cushing’s syndrome. 4 , 2 , 19 , 10 However, it is important to note the potential for a stronger immunosuppressive effect with deflazacort, which may increase the risk of opportunistic infections. 3 When considering deflazacort, a careful evaluation of the risks and benefits is essential. More research is needed to thoroughly assess the long-term safety and efficacy of deflazacort. Future research should focus on addressing the inconsistencies observed in current studies regarding the immunosuppressive effect and growth velocity impact of deflazacort. 3 5 , 15 , 11 By standardizing research designs and participant characteristics, we can gain a more definitive understanding of the impact of deflazacort.

Literature analysis of 20 papers
Positive Content
15
Neutral Content
4
Negative Content
1
Article Type
9
0
0
1
20
1.

Comparison of the pharmacodynamic effects of deflazacort and prednisolone in healthy subjects.

Author: BabadjanovaG, AllolioB, VollmerM, ReinckeM, SchulteH M

Anti-inflammatory
Glucocorticoid
Adverse effects

The study focused on the equipotency ratio of deflazacort versus other glucocorticoids for the assumption of fewer adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Deflazacort: a glucocorticoid with few metabolic adverse effects but important immunosuppressive activity.

Author: Gonzalez-PerezOscar, LuquinSonia, Garcia-EstradaJoaquin, Ramos-RemusCesar

Autoimmune disorders treatment
Opportunistic infection

Deflazacort, a synthetic glucocorticoid, demonstrated greater immunosuppressive activity than previously thought, potentially increasing the risk of opportunistic infections. Further studies are needed to establish its precise immunosuppressive potency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Compared clinical efficacy and bone metabolic effects of low-dose deflazacort and methyl prednisolone in male inflammatory arthropathies: a 12-month open randomized pilot study.

Author: SaviolaG, Abdi AliL, Shams EddinS, CoppiniA, CavalieriF, CampostriniL, SaccoS, BucciM, CirinoG, RossiniM

PsA treatment
RA treatment
Bone resorption

Deflazacort and methylprednisolone were found to be equally effective in treating active rheumatoid arthritis and psoriatic arthritis when adjusted for their relative potency. This study involving 21 male patients found that deflazacort at a dose of 7.5 mg was equivalent to methylprednisolone at 4 mg.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of deflazacort vs. methylprednisone: a randomized study in kidney transplant patients.

Author: FerrarisJorge R, PasqualiniTitania, AlonsoGuillermo, LegalSusana, SorrochePatricia, GalichAna M, JasperHéctor,

Bone loss prevention
Kidney transplant patients
Lean body mass
Linear growth
Lipoprotein profile
Fat accumulation
Insulin sensitivity

Deflazacort therapy, compared to methylprednisone, may improve linear growth and lean body mass, prevent excessive bone loss and fat accumulation, and improve lipoprotein profile without reducing insulin sensitivity in prepubertal patients after kidney transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Hydrocortisone and deflazacort induce different effects on vitamin D receptor level increase produced by 1,25-dihydroxyvitamin D3 in rat osteoblast-like UMR-106 cells.

Author: GuerreroRosa, de la PiedraConcepción, TeixeiroEmma, BragadoRafael, TrabaMaria Luisa

Bone Growth

1,25-dihydroxyvitamin D3 (1,25(OH)2D3) increases vitamin D receptor (VDR) levels, while hydrocortisone and deflazacort do not, but they can affect VDR levels when combined with 1,25(OH)2D3.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of deflazacort and cortisone on cellular proliferation in the rat thymus.

Author: LattaKay, KriegRichard J, Carbajo-PérezEduardo, CarbajoSantiago, ChanJames C M

Fewer side effects
Immunosuppression

This study compared the effects of deflazacort, a glucocorticoid, with cortisone on the proliferative activity of thymus cells in rats. The study found that deflazacort had a similar immunosuppressive effect as cortisone, but with potentially fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Deflazacort versus prednisone in patients with giant cell arteritis: effects on bone mass loss.

Author: CacoubP, ChemlalK, KhalifaP, WechslerB, De GennesC, BelmatougN, CohenP, ZizaJ M, VerdoncqB, PietteJ C

Bone loss

Deflazacort did not result in less bone loss than prednisone in older patients taking long-term glucocorticoids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

The effects of the glucocorticoids prednisolone, deflazacort and beclomethasone-dipropionate on the RM 3/1 macrophage in human peripheral blood.

Author: Zwadlo-KlarwasserG, SchmutzlerW

Glucocorticoid side effects

This study examined the efficacy of oral and topical glucocorticoid (GC) administration in stimulating the production of RM 3/1 macrophages from human blood monocytes. Deflazacort was found to be less effective than expected, while topical beclomethasone did not cause systemic GC reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Effects of deflazacort versus prednisone on bone mass, body composition, and lipid profile: a randomized, double blind study in kidney transplant patients.

Author: LippunerK, CasezJ P, HorberF F, JaegerP

Decreased bone loss
Improved lipid profile
Prevents fat accumulation

Deflazacort was found to be less detrimental to bone mineral density than prednisone in kidney transplant patients. Deflazacort also prevented fat accumulation and worsening of the lipid profile.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Effects of deflazacort immunosuppression on long-term growth and growth factors after renal transplantation.

Author: FerrarisJ R, PennisiP, PasqualiniT, JasperH

Effective treatment
Improved growth

Deflazacort was found to be as effective as methylprednisone in immunosuppressive treatment for renal transplantation patients, with potential benefits for growth prognosis in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Comparison of the pharmacodynamic effects of deflazacort and prednisolone in healthy subjects.

Author: BabadjanovaG, AllolioB, VollmerM, ReinckeM, SchulteH M

Anti-inflammatory
Glucocorticoid
Adverse effects

The study focused on the equipotency ratio of deflazacort versus other glucocorticoids for the assumption of fewer adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Acute effects of deflazacort and prednisone on rates of mineralization and bone formation.

Author: Lo CascioV, KanisJ A, BenetonM N, BertoldoF, AdamiS, PoggiG, ZanolinM E

Bone formation assessment

This study investigated the effects of corticosteroids on bone formation in humans, finding no significant differences between prednisone and deflazacort.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Dose-dependent effects of deflazacort and prednisone on growth and skeletal maturation.

Author: AicardiG, BensoL, VignoloM, TerragnaA, VerrinaE, CordoneG, CoppoR, SerniaO, SardellaM L, Di BattistaE

Improved skeletal maturation
Reduced growth impairment

Deflazacort, a new glucocorticoid, had less negative effects on growth and skeletal maturation than prednisone in prepubertal children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Preliminary experience with deflazacort, a new synthetic steroid with fewer undesirable side effects, in heart transplant patients.

Author: ArizónJ M, AnguitaM, VallésF, MonteroA, SanchoM, López-RubioF, LatreJ M, CallejaF, CasaresJ, RománM

Fewer side effects
Lower blood sugar
Lower cholesterol
No benefit over prednisone

Deflazacort is a promising alternative to prednisone in heart transplant patients, reducing glycemia, total cholesterol, and LDL-cholesterol without affecting rejection or infection rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Protective effects of deflazacort on allergen-specific conjunctival challenge.

Author: CiprandiG, BuscagliaS, IudiceA, PesceG P, BagnascoM, CanonicaG W

Allergen-Specific Conjunctivitis Treatment

Deflazacort is a drug used to treat allergic conjunctivitis. In a double-blind study of 24 patients with allergic conjunctivitis, deflazacort was found to be effective in reducing the severity of late-phase reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast-enriched cells.

Author: CanalisE, AvioliL

Bone sparing
Increased bone formation

Deflazacort and cortisol were found to have similar effects on bone formation in vitro. Both steroids inhibited DNA and collagen synthesis in cultures of fetal rat calvariae and osteoblast-enriched cells. At higher doses, both steroids also decreased collagen degradation and IGF-I production.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Glucocorticoid-induced osteoporosis in the lumbar spine, forearm, and mandible of nephrotic patients: a double-blind study on the high-dose, long-term effects of prednisone versus deflazacort.

Author: OlgaardK, StormT, van WowernN, DaugaardH, EgfjordM, LewinE, BrandiL

Nephrotic syndrome treatment
Bone mineral loss

Both prednisone and deflazacort reduced bone mineral content in patients with nephrotic syndrome. However, deflazacort had a significantly slower bone decay rate than prednisone, particularly in the forearm.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Effects of long-term maintenance therapy with a new glucocorticoid, deflazacort, on mineral metabolism and statural growth.

Author: BalsanS, StéruD, BourdeauA, GrimbergR, LenoirG

Glucocorticoid therapy
Growth acceleration
Steroid side effect reduction
Osteoporosis
iPTH(1-84) increase

Deflazacort was substituted for prednisone in 9 children with renal or connective tissue disorders. Deflazacort showed excellent therapeutic effects, with reduced or absent steroid side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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