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A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias <i>In Vivo</i>.

Author: AntanasijevicAleksandar, BoslandMaarten C, CaffreyMichael, De MoerlooseBarbara, GoossensSteven, KabirovKasim K, Kajdacsy-BallaAndre, LammensTim, LavieArnon, LiuLi, LyubimovAlexander V, MahmudDolores L, MerrillBradley J, MondelaersVeerle, NguyenHien Anh, OhAnnie, PeirsSofie, RondelliDamiano, SaunthararajahYogen, SchalkAmanda M, SchlichtMichael J, SuYing, Van VlierberghePieter, ZhangJenny Y

Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new l-asparaginase-based therapy for acute lymphoblastic leukemia (ALL) is less toxic compared with FDA-approved high l-glutaminase enzymes. It was highly efficacious against both T- and B-cell ALL, while displaying reduced acute toxicity features.
Paper Details　
Original Abstract of the Article :
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL cells. In addition to hydrolyzing the amino acid l-a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29343523

データ提供：米国国立医学図書館（NLM）

A Novel L-Asparaginase: A Promising Treatment for Acute Lymphoblastic Leukemia

This study introduces a novel l-asparaginase with reduced l-glutaminase coactivity, a potentially safer and more effective treatment for acute lymphoblastic leukemia (ALL). The researchers investigated the efficacy of this new enzyme variant in treating both T- and B-cell ALL.

A Novel L-Asparaginase: Enhanced Efficacy and Reduced Toxicity

The study demonstrates that the novel l-asparaginase variant exhibits high efficacy against both T- and B-cell ALL, while displaying reduced acute toxicity. This finding suggests that this new enzyme variant may offer a significant advantage over existing l-asparaginase treatments, which often cause side effects due to l-glutaminase activity.

A Safer and More Effective Treatment for ALL

This research highlights the potential of this novel l-asparaginase variant to improve the treatment of ALL. The reduced l-glutaminase coactivity and enhanced efficacy suggest a safer and more effective therapeutic option for patients with this type of cancer. The study underscores the importance of ongoing research and development of new and innovative therapies for ALL.

Dr. Camel's Conclusion

Imagine a desert oasis where travelers find a new and refreshing source of water, providing a vital lifeline. This study is like discovering that new source—a novel l-asparaginase—offering a potentially safer and more effective treatment for ALL. The study highlights the potential of this new enzyme variant to improve patient outcomes and inspire hope for those battling this challenging disease. This research reminds us that the pursuit of knowledge, like navigating a vast desert, can lead to breakthroughs that improve lives.
Date :
  1. Date Completed 2019-05-20
  2. Date Revised 2019-05-20
Further Info :

Pubmed ID

29343523

DOI: Digital Object Identifier

NIHMS935985

Related Literature

Article Analysis
・Side Effects of l-glutamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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