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Synthesis of novel quinine analogs and evaluation of their effects on Trypanosoma cruzi.
Author: CeoleLigia F, GandhiHirenkumar, O'SullivanTimothy P, SoaresMaurilio J, VillamizarLuz H
Original Abstract of the Article :
Chagas disease is a tropical disease caused by the hemoflagellate protozoan Trypanosoma cruzi. There is no vaccine for Chagas disease and available drugs (e.g., benznidazole) are effective only during the acute phase, displaying a variable curative activity in the established chronic form of the dis...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.4155/fmc-2017-0184
データ提供:米国国立医学図書館(NLM)
New Quinine Analogs for Treating Chagas Disease
Chagas disease, a debilitating tropical illness, poses a significant public health challenge. This study focuses on the development of novel quinine analogs as potential treatments for Chagas disease, an illness caused by the parasite Trypanosoma cruzi. The researchers synthesized a library of quinine derivatives using a chemical process known as Heck chemistry and evaluated their efficacy against various stages of the parasite's life cycle. The study aimed to identify new drug candidates with enhanced efficacy and improved safety profiles compared to existing treatments.
Fighting Chagas: New Weapons in the Arsenal
This research offers a promising avenue for addressing the unmet needs in Chagas disease treatment. The study's findings demonstrate the potential of quinine analogs as effective agents against T. cruzi. This research paves the way for the development of new and potentially more effective therapies for Chagas disease, providing hope for millions affected by this neglected tropical illness.
Hope on the Horizon
This research is like a desert bloom, offering a glimmer of hope in the fight against Chagas disease. The development of new and effective treatments is crucial for addressing this neglected tropical illness. This research encourages continued efforts to find innovative solutions for Chagas disease, bringing relief to those affected by this debilitating condition.
Dr.Camel's Conclusion
This study exemplifies the ongoing quest for new and effective treatments for neglected diseases like Chagas disease. The development of quinine analogs holds promise for improving therapeutic options and offering hope for those affected by this debilitating illness. This research underscores the importance of continued research and development in the field of neglected tropical diseases.
Date :
- Date Completed 2018-11-19
- Date Revised 2019-12-10
Further Info :
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English
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