Synthesis of novel quinine analogs and evaluation of their effects on Trypanosoma cruzi.

Author: CeoleLigia F, GandhiHirenkumar, O'SullivanTimothy P, SoaresMaurilio J, VillamizarLuz H

Paper Details 
Original Abstract of the Article :
Chagas disease is a tropical disease caused by the hemoflagellate protozoan Trypanosoma cruzi. There is no vaccine for Chagas disease and available drugs (e.g., benznidazole) are effective only during the acute phase, displaying a variable curative activity in the established chronic form of the dis...See full text at original site
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引用元:
https://doi.org/10.4155/fmc-2017-0184

データ提供:米国国立医学図書館(NLM)

New Quinine Analogs for Treating Chagas Disease

Chagas disease, a debilitating tropical illness, poses a significant public health challenge. This study focuses on the development of novel quinine analogs as potential treatments for Chagas disease, an illness caused by the parasite Trypanosoma cruzi. The researchers synthesized a library of quinine derivatives using a chemical process known as Heck chemistry and evaluated their efficacy against various stages of the parasite's life cycle. The study aimed to identify new drug candidates with enhanced efficacy and improved safety profiles compared to existing treatments.

Fighting Chagas: New Weapons in the Arsenal

This research offers a promising avenue for addressing the unmet needs in Chagas disease treatment. The study's findings demonstrate the potential of quinine analogs as effective agents against T. cruzi. This research paves the way for the development of new and potentially more effective therapies for Chagas disease, providing hope for millions affected by this neglected tropical illness.

Hope on the Horizon

This research is like a desert bloom, offering a glimmer of hope in the fight against Chagas disease. The development of new and effective treatments is crucial for addressing this neglected tropical illness. This research encourages continued efforts to find innovative solutions for Chagas disease, bringing relief to those affected by this debilitating condition.

Dr.Camel's Conclusion

This study exemplifies the ongoing quest for new and effective treatments for neglected diseases like Chagas disease. The development of quinine analogs holds promise for improving therapeutic options and offering hope for those affected by this debilitating illness. This research underscores the importance of continued research and development in the field of neglected tropical diseases.

Date :
  1. Date Completed 2018-11-19
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

29380636

DOI: Digital Object Identifier

10.4155/fmc-2017-0184

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English

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