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In vitro effects of promethazine on cell morphology and structure and mitochondrial activity of azole-resistant Candida tropicalis.

Author: AlencarLucas Pereira, BrilhanteRaimunda Sâmia Nogueira, Castelo-BrancoDébora de Souza Collares Maia, CordeiroRossana de Aguiar, CâmaraLília Maria Carneiro, PereiraVandbergue Santos, RochaMarcos Fábio Gadelha, SidrimJosé Júlio Costa, de Jesus EvangelistaAntonio José, de Lima-NetoReginaldo Gonçalves, de OliveiraJonathas Sales

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Promethazine was found to exhibit antifungal activity against Candida tropicalis, both in planktonic cells and mature biofilms. Promethazine also presented synergy with azole antifungals against resistant C. tropicalis.
Paper Details　
Original Abstract of the Article :
The aim of this study was to evaluate the effect of promethazine on the antifungal minimum inhibitory concentrations against planktonic cells and mature biofilms of Candida tropicalis, as well as investigate its potential mechanisms of cell damage against this yeast species. Three C. tropicalis isol...See full text at original site
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引用元：
https://doi.org/10.1093/mmy/myx088

データ提供：米国国立医学図書館（NLM）

Promethazine: A Potential Weapon Against Azole-Resistant Candida tropicalis

This study ventures into the microbial world, investigating the potential of promethazine, an antihistamine, as a weapon against azole-resistant Candida tropicalis, a yeast that can cause infections. Imagine a camel caravan battling against a swarm of desert flies - this study explores how promethazine can help fight off this pesky yeast. The researchers found that promethazine exhibited antifungal activity against C. tropicalis, both alone and in combination with azole drugs. This exciting discovery suggests that promethazine could potentially help overcome azole resistance, a growing challenge in treating fungal infections.

Promethazine: Synergistic Action Against Candida tropicalis

The study demonstrated that promethazine can enhance the antifungal activity of azole drugs against resistant C. tropicalis strains. These findings suggest that promethazine could potentially play a role in overcoming the increasing problem of azole resistance in Candida infections.

Fighting Fungal Infections

Candida infections can be a significant health concern, especially for individuals with weakened immune systems. This research highlights the importance of ongoing research to develop new and effective treatments against fungal infections, particularly those resistant to conventional therapies.

Dr. Camel's Conclusion

This study offers a glimmer of hope in the fight against azole-resistant Candida tropicalis, highlighting the potential of promethazine as a valuable weapon in the arsenal against fungal infections. It underscores the importance of exploring new treatment strategies to overcome resistance and combat the growing threat of fungal infections.

Date :
  1. Date Completed 2019-01-14
  2. Date Revised 2019-01-14
Further Info :

Pubmed ID

29420801

DOI: Digital Object Identifier

10.1093/mmy/myx088

Related Literature

Article Analysis
・Effects of promethazine
SNS
PICO Info
in preparation
Languages

English

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