<i>In Vitro</i> Study of the Susceptibility of Clinical Isolates of Trichomonas vaginalis to Metronidazole and Secnidazole.

Author: AycockCheri, GhoshArindam P, SchwebkeJane R

Paper Details 
Original Abstract of the Article :
Nitroimidazoles (metronidazole [MTZ] and tinidazole [TNZ]) are the only drugs recommended for treatment of <i>Trichomonas vaginalis</i> infections. MTZ resistance occurs in 4% to 10% of cases of vaginal trichomoniasis (R. D. Kirkcaldy et al., Emerg Infect Dis 18:939-943, 2012; J. R. Schwebke and F. ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913958/

データ提供:米国国立医学図書館(NLM)

Trichomonas vaginalis: Navigating the Shifting Sands of Antibiotic Resistance

Trichomonas vaginalis, a microscopic parasite that thrives in the desert of the female reproductive tract, can cause a range of discomforting symptoms. While nitroimidazoles like metronidazole and tinidazole have been the traditional weapons against this parasitic foe, the emergence of resistance is like a looming sandstorm. This study investigates the susceptibility of clinical isolates of T. vaginalis to metronidazole and secnidazole, two commonly used antibiotics. The researchers tested the effectiveness of these drugs against a collection of clinical isolates, revealing intriguing differences in their susceptibility. The study underscores the importance of monitoring antibiotic resistance and exploring alternative treatment strategies.

Navigating the Desert of Antibiotic Resistance

The study found that secnidazole demonstrated superior in vitro activity compared to metronidazole. This finding suggests that secnidazole may be a more effective weapon against T. vaginalis in the face of growing resistance. The study highlights the need for vigilance in monitoring antibiotic resistance patterns to ensure continued effectiveness of treatment strategies.

Oasis of Effective Treatment

This study underscores the importance of understanding antibiotic resistance in treating T. vaginalis infections. The findings suggest that secnidazole may be a more effective alternative to metronidazole, offering a potential oasis of effective treatment in a landscape of growing resistance. The study emphasizes the need for ongoing research and development of new treatment options to ensure continued effectiveness against this persistent parasitic foe.

Dr.Camel's Conclusion

This study reveals the importance of vigilance in monitoring antibiotic resistance against T. vaginalis. The findings suggest that secnidazole may be a more effective alternative to metronidazole, offering a potential oasis of effective treatment in a landscape of growing resistance. Researchers must continue to explore new strategies and therapies to effectively navigate the shifting sands of antimicrobial resistance.

Date :
  1. Date Completed 2019-04-19
  2. Date Revised 2019-04-19
Further Info :

Pubmed ID

29439963

DOI: Digital Object Identifier

PMC5913958

Related Literature

SNS
PICO Info
in preparation
Languages

English

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