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Evaluating the Effect of Six Proton Pump Inhibitors on the Antiplatelet Effects of Clopidogrel.

Author: BatesVernice, GengoFran M, PrzespolewskiEugene R, RainkaMichelle, SmithNicholas M, WestphalErica S

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the potential interaction between clopidogrel and proton pump inhibitors (PPIs), particularly esomeprazole and omeprazole. While previous studies have raised concerns about PPIs compromising clopidogrel's antiplatelet effects, this study suggests that the interaction may not be as robust as previously thought, calling for further investigation to assess the clinical relevance of this interaction.
Paper Details　
Original Abstract of the Article :
Cytochrome P450 (CYP) enzymes are responsible for the conversion of clopidogrel into its active metabolite and the metabolism of proton pump inhibitors (PPIs), which may also inhibit CYP enzymes. A current Food and Drug Administration advisory suggests avoiding esomeprazole and omeprazole while taki...See full text at original site
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引用元：
https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.01.011

データ提供：米国国立医学図書館（NLM）

Navigating Drug Interactions: Clopidogrel and Proton Pump Inhibitors

The field of pharmacotherapy often involves navigating complex drug interactions, which can impact patient outcomes. This study investigates the potential interaction between clopidogrel, a commonly used antiplatelet medication, and proton pump inhibitors (PPIs). The study aimed to assess the robustness of the interaction between these drugs, addressing concerns about PPIs potentially compromising clopidogrel's antiplatelet effects.

Understanding the Interaction: Clopidogrel and PPIs

The study provides valuable insights into the interaction between clopidogrel and PPIs. It emphasizes the need for careful consideration of potential drug interactions, especially in situations where there is a risk of compromised efficacy. The findings highlight the importance of ongoing research and clinical vigilance in monitoring drug interactions to ensure optimal patient care.

Ensuring Safety and Effectiveness: Key Considerations

If you are taking clopidogrel, it's crucial to discuss any other medications you are taking with your doctor or pharmacist. Understanding potential drug interactions is essential for optimizing treatment outcomes and minimizing risks. This information empowers patients to actively participate in their healthcare journey, ensuring safe and effective treatment.

Dr.Camel's Conclusion

Imagine a desert with winding paths, each leading to a different destination. Drug interactions are like these paths, some leading to desired outcomes and others potentially leading to complications. This research provides valuable insights into the interaction between clopidogrel and PPIs, helping us navigate these paths with greater caution and ensure a smoother journey towards optimal health.

Date :
  1. Date Completed 2018-08-27
  2. Date Revised 2018-08-27
Further Info :

Pubmed ID

29449127

DOI: Digital Object Identifier

10.1016/j.jstrokecerebrovasdis.2018.01.011

SNS
PICO Info
in preparation
Languages

English

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