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Cytochrome P450 2C9-natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data.

Author: AhemadNafees, OngChin Eng, OthmanIekhsan, PalanisamyUma Devi, PanYan, TanBoon Hooi, YiapBeow Chin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the potential for interaction between three naturally derived compounds (glucosamine, chondroitin, and diacerein) and the CYP2C9 enzyme. It found that diacerein exhibited moderate inhibition of CYP2C9, while glucosamine and chondroitin showed negligible inhibition.
Paper Details　
Original Abstract of the Article :
Many dietary supplements are promoted to patients with osteoarthritis (OA) including the three naturally derived compounds, glucosamine, chondroitin and diacerein. Despite their wide spread use, research on interaction of these antiarthritic compounds with human hepatic cytochrome P450 (CYP) enzymes...See full text at original site
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引用元：
https://doi.org/10.1002/bdd.2127

データ提供：米国国立医学図書館（NLM）

Dietary Supplements and Drug Interactions: A Closer Look at Osteoarthritis Treatments

Osteoarthritis (OA) is a common condition characterized by joint pain and stiffness. Many individuals with OA seek relief through dietary supplements, such as glucosamine, chondroitin, and diacerein. This research investigates the potential for interactions between these supplements and the liver enzyme cytochrome P450 2C9 (CYP2C9), which plays a crucial role in drug metabolism.

Drug Interactions: A Potential Pitfall for Osteoarthritis Treatments

The researchers found that diacerein, a commonly used OA supplement, inhibited CYP2C9 activity. This finding suggests that diacerein could potentially interfere with the metabolism of other drugs, leading to adverse effects. Glucosamine and chondroitin, on the other hand, showed minimal inhibitory effects on CYP2C9.

A Balancing Act: Choosing Osteoarthritis Treatments Wisely

This research highlights the importance of considering potential drug interactions when managing OA. Patients taking other medications should discuss the potential risks of using diacerein with their healthcare provider. For individuals with OA, it's crucial to choose treatments that are safe and effective for their individual needs. Just as a camel navigates a complex desert landscape, choosing the right treatment pathway requires careful consideration of potential risks and benefits.

Dr. Camel's Conclusion

Just as a camel needs to carefully navigate a desert terrain, individuals with OA need to navigate the complex landscape of treatment options. This research underscores the importance of considering potential drug interactions, especially when using dietary supplements like diacerein.

Date :
  1. Date Completed 2018-09-24
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

29488228

DOI: Digital Object Identifier

10.1002/bdd.2127

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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