Effective treatment of glucosamine and chondroitin: A Synthesis of Findings from 24 Studies

  1. Home
  2. Effective treatment of glucosamine and chondroitin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of glucosamine and chondroitin: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of glucosamine and chondroitin: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Glucosamine and chondroitin have shown promise in alleviating osteoarthritis symptoms in both dogs and cats. 3 , 4 . A study involving dogs with osteoarthritis found that a dietary supplement containing a blend of Boswellia serrata Roxb. chlorophyll, green tea extract, glucosamine, chondroitin sulfate, hyaluronic acid, and non-hydrolyzed type II collagen effectively reduced pain and clinical signs. 3 . Another study on cats with degenerative joint disease showed that glucosamine/chondroitin sulfate supplementation led to pain relief and improved activity. 4 . These studies highlight the potential safety of these supplements. 3 , 4 .

Research using a rat osteoarthritis model indicated that intra-articular injection of human deciduous dental pulp stem cells (hDPSCs) outperformed pharmacological treatments like diacerein and glucosamine-chondroitin in inhibiting the progression of osteoarthritis. 5 . Glucosamine and chondroitin supplements have also been suggested to potentially slow down osteoarthritis progression. 19 .

Studies hint at the possibility of glucosamine and chondroitin supplements relieving osteoarthritis symptoms in humans. 23 , 9 , 12 . However, their effectiveness varies among individuals, and they may not be universally beneficial. 9 . It’s important to note that glucosamine and chondroitin can interact with certain medications, making it crucial to consult a doctor before using them. 11 .

Benefits and Risks

Benefits Summary

Glucosamine and chondroitin hold the potential to alleviate pain associated with osteoarthritis in dogs and cats. 3 , 4 . They may also play a role in slowing the progression of osteoarthritis. 19 . Research suggests that these supplements could provide symptom relief in humans as well. 23 , 9 , 12 . These supplements are generally considered safe. 3 , 4 .

Risks Summary

Glucosamine and chondroitin are generally considered safe supplements. 3 , 4 . However, they can interact with certain medications. 11 . Additionally, glucosamine has been reported to potentially weaken bone strength. 7 . Therefore, consulting a doctor before using glucosamine and chondroitin is highly recommended.

Comparison of Studies

Commonalities in Studies

Numerous studies have shown that glucosamine and chondroitin can be effective in reducing osteoarthritis symptoms. 3 , 4 , 9 , 12 . Furthermore, these supplements are generally considered safe. 3 , 4 .

Differences in Studies

While glucosamine and chondroitin have been studied extensively, their effectiveness and safety assessments vary across different research studies. 9 . For example, the effectiveness of combining glucosamine and chondroitin has yielded conflicting results. 9 , 12 . Similarly, a definitive answer regarding the ability of glucosamine and chondroitin to slow down osteoarthritis progression is still elusive. 19 .

Consistency and Inconsistencies in Results

While glucosamine and chondroitin show promise in alleviating osteoarthritis symptoms, it's important to remember that their effectiveness can vary significantly among individuals, and not everyone will experience the same benefits. 9 . The effectiveness of combining glucosamine and chondroitin is also a subject of debate, with research findings not always aligning. 9 , 12 . This highlights the need to consult a healthcare professional before incorporating glucosamine and chondroitin into your regimen.

Considerations for Real-World Application

Glucosamine and chondroitin are potential supplements for managing osteoarthritis symptoms. 3 , 4 , 9 . However, it's crucial to remember they are not medications and may take time to show effects. 10 . Their effectiveness can vary widely, and not everyone will experience a positive response. 9 . Consulting a healthcare professional before using glucosamine and chondroitin is vital.

Limitations of Current Research

Research on glucosamine and chondroitin is still ongoing and not completely conclusive. 10 . There is a particular need for large-scale studies involving human participants. 9 . Additionally, further investigation is needed to establish whether glucosamine and chondroitin can effectively slow down osteoarthritis progression. 19 .

Future Research Directions

Large-scale clinical trials are needed to definitively assess whether glucosamine and chondroitin can slow the progression of osteoarthritis. 10 . Further research is required to determine if glucosamine and chondroitin are beneficial for different types of osteoarthritis. 12 . Moreover, it’s important to investigate the effectiveness of combining glucosamine and chondroitin with other therapeutic approaches. 10 .

Conclusion

Glucosamine and chondroitin are potential supplements that may offer symptom relief for osteoarthritis. 3 , 4 , 9 . However, they are not medications and their effectiveness can vary, taking time to show results. 10 . Remember, not everyone will benefit from these supplements. Consulting a healthcare professional before using glucosamine and chondroitin is essential.

Literature analysis of 24 papers
Positive Content
23
Neutral Content
1
Negative Content
0
Article Type
5
5
3
5
23
2.

Differences in Serum Biomarkers Between Combined Glucosamine and Chondroitin Versus Celecoxib in a Randomized, Double-blind Trial in Osteoarthritis Patients.

Author: NavarroSandi L, HerreroMarta, MartinezHelena, ZhangYuzheng, LaddJon, LoEdward, ShelleyDavid, RandolphTimothy W, LampeJohanna W, LampePaul D

Anti-inflammatory effects
GH+CS
Inflammatory conditions treatment
Potential for joint pain relief
Safer alternative
Needs further research
Unclear effectiveness compared to NSAIDs

Glucosamine hydrochloride plus chondroitin sulfate (GH+CS) is a common supplement for joint pain. While non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib are also used for joint pain, they can have side effects. Research suggests that GH+CS may have anti-inflammatory properties, offering a potentially safer alternative to NSAIDs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial.

Author: MartelloElisa, BigliatiMauro, AdamiRaffaella, BiasibettiElena, BisanzioDonal, MeineriGiorgia, BruniNatascia

Pain relief
Reduced clinical signs

A dietary supplement containing a mixture of Boswellia serrata Roxb., chlorophyll, green tea extract, glucosamine, chondroitin sulfate, hyaluronic acid, and non-hydrolyzed type II collagen significantly reduced pain and clinical signs in dogs with osteoarthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial.

Author: CunninghamRachael, GruenMargaret E, ThomsonAndrea, LascellesB Duncan X

Activity-enhancing
Pain-relieving

This study evaluated the pain-alleviating and activity-enhancing effects of glucosamine/chondroitin sulfate (Dasuquin) in cats with degenerative joint disease (DJD). The nutritional supplement was hypothesized to produce pain-relieving and activity-enhancing effects in cats with painful DJD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

6.

Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp.

Author: LeeDong Hoon, CaoChao, ZongXiaoyu, ZhangXuehong, O'ConnellKelli, SongMingyang, WuKana, DuMengmeng, CaoYin, GiovannucciEdward L, KantorElizabeth D

This study found that glucosamine/chondroitin use was associated with lower risks of high-risk and overall conventional adenoma in older adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial.

Author: NashRobert J, AzantsaBoris Kg, SharpHazel, ShanmughamVelmurugan

Knee OA Management

This study evaluated the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber), against glucosamine-chondroitin (GC) in the management of moderate knee osteoarthritis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.

Author: Simental-MendíaMario, Sánchez-GarcíaAdriana, Vilchez-CavazosFélix, Acosta-OlivoCarlos A, Peña-MartínezVíctor M, Simental-MendíaLuis E

Reduce pain

This systematic review and meta-analysis investigated the efficacy of glucosamine and chondroitin sulfate on knee osteoarthritis symptoms. It found that glucosamine or chondroitin sulfate reduced pain, but their combination did not have an additional effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Comparative effectiveness of glucosamine, chondroitin, acetaminophen or celecoxib for the treatment of knee and/or hip osteoarthritis: a network meta-analysis.

Author: ZhuXiaoyue, WuDandong, SangLingli, WangYidan, ShenYi, ZhuangXun, ChuMinjie, JiangLiying

Pain relief
Physical function improvement
Stiffness reduction
Gastrointestinal adverse effects

Celecoxib was the most effective treatment for pain in patients with knee and/or hip osteoarthritis, followed by a combination of glucosamine and chondroitin. Acetaminophen was the least effective.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

14.

Efficacy of pulsed Nd:YAG laser in the treatment of patients with knee osteoarthritis: a randomized controlled trial.

Author: AlayatMohamed Salaheldien Mohamed, AlyTarek Helmy Ahmed, ElsayedAly Elsayed Mohamed, FadilAmmar Suliman Mohamed

KOA pain relief
Knee function improvement

This study investigated the effectiveness of pulsed Nd:YAG laser combined with glucosamine/chondroitin sulfate (GCS) and exercises for treating knee osteoarthritis (KOA). The combination therapy demonstrated greater effectiveness compared to GCS and exercises alone, showing significant reductions in pain, functional disability, and synovial thickness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study.

Author: KantorElizabeth D, ZhangXuehong, WuKana, SignorelloLisa B, ChanAndrew T, FuchsCharles S, GiovannucciEdward L

CRC prevention

The study suggests a protective association between the use of glucosamine and chondroitin supplements and a reduced risk of colorectal cancer (CRC). While the results are promising, further research is needed to confirm this association and understand the potential mechanisms of chemoprevention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

16.

Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee.

Author: ZengChao, WeiJie, LiHui, WangYi-lun, XieDong-xing, YangTuo, GaoShu-guang, LiYu-sheng, LuoWei, LeiGuang-hua

Improved function
Pain relief
Reduced joint space narrowing
Gastrointestinal adverse effects

This meta-analysis of 54 studies found that glucosamine plus chondroitin, glucosamine alone, and celecoxib are all more effective than placebo in treating knee osteoarthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Supplementary methods in the nonsurgical treatment of osteoarthritis.

Author: Percope de AndradeMarco Antônio, CamposTúlio Vinícius de Oliveira, Abreu-E-SilvaGuilherme Moreira de

Improved function
Pain relief
No effect on disease progression

There is no evidence that nutraceuticals or viscosupplementation influences OA's natural progression. However, some of these agents seem to reduce pain and improve function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Effects of glucosamine and chondroitin supplementation on knee osteoarthritis: an analysis with marginal structural models.

Author: YangShibing, EatonCharles B, McAlindonTimothy E, LapaneKate L

The combination of glucosamine and chondroitin did not show significant benefits in relieving knee symptoms or slowing disease progression in patients with knee osteoarthritis. No clinically significant differences were found between users and non-users of glucosamine/chondroitin in WOMAC pain, stiffness, function, or joint space width.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Efficacy of an oral hyaluronate and collagen supplement as a preventive treatment of elbow dysplasia.

Author: Martí-AnguloSimón, García-LópezNúria, Díaz-RamosAna

Improved symptoms of dysplasia
Protection against dysplasia

Elbow dysplasia is a common condition in Labrador dogs. This study compares the effectiveness of an oral supplement containing hyaluronic acid, collagen, glucosamine, chondroitin sulfate, and gamma oryzanol in preventing and treating elbow dysplasia. The results suggest that the supplement may help reduce the incidence and severity of elbow dysplasia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.

Author: GallagherBrian, TjoumakarisFotios P, HarwoodMarc I, GoodRobert P, CiccottiMichael G, FreedmanKevin B

Chondroprotective properties
Osteoarthritis treatment

This study identifies 12 treatments, including medications and nutraceuticals, that may possess chondroprotective properties for osteoarthritis. It suggests these treatments could be effective in managing the disease and protecting cartilage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

The effects of three-month oral supplementation with a nutraceutical and exercise on the locomotor pattern of aged horses.

Author: HiglerM H, BrommerH, L'AmiJ J, de GrauwJ C, NielenM, van WeerenP R, LavertyS, BarneveldA, BackW

Improved joint function

Glucosamine and chondroitin sulfate have potential anti-inflammatory effects on articular tissues. Their effectiveness in treating stiff joints in horses, which are likely caused by inflammation, needs further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer.

Author: GreenleeHeather, CrewKatherine D, ShaoTheresa, KranwinkelGrace, KalinskyKevin, MaurerMatthew, BrafmanLois, InselBeverly, TsaiWei Yann, HershmanDawn L

Glucosamine/chondroitin improves AI-induced arthralgias
Dyspepsia
Headache
Nausea

Glucosamine/chondroitin resulted in moderate improvements in aromatase inhibitor-induced arthralgias, with minimal side effects and no changes in estradiol levels.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Nutraceuticals in the management of osteoarthritis : a critical review.

Author: RagleRyan L, SawitzkeAllen D

Functional improvement
Pain relief
Structural outcome

Osteoarthritis (OA) is a debilitating disease that is becoming more common. While there are many treatments, including medications, physical therapy, and surgery, they are only marginally effective. Nutraceuticals, including glucosamine, chondroitin, collagen hydrolysates, and avocado-soybean unsaponifiables, may offer some benefit for OA. While the evidence is mixed, these supplements are generally safe and may be beneficial for certain patients. More research is needed to determine the optimal use of nutraceuticals for OA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.